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Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
Acta Neurol Scand 2000; 101(4):217-23AN

Abstract

OBJECTIVES

A few reports have shown elevated fasting total plasma homocysteine (tHcy) in patients taking antiepileptic drugs (AEDs). In this study we determined the influence of AEDs on plasma tHcy levels prior to and following methionine loading.

MATERIAL AND METHODS

Thirty-four patients on different AEDs and 34 matched controls were recruited. Blood samples were drawn prior to and 6 h post-methionine loading (6h-PML).

RESULTS

The patients on AEDs inducing the cytochrome P450 (carbamazepine, phenytoin, phenobarbital, primidone), had higher fasting and 6h-PML plasma tHcy concentrations than the controls (P = 0.01 and P<0.001). Patients on AED inhibiting the cytochrome P450 (valproate [VPA]), had lower 6h-PML p-tHcy concentrations than controls (P = 0.01).

CONCLUSIONS

Our data indicate that not only fasting but also 6h-PML tHcy levels should be determined in order to identify hyperhomocysteinemia among patients on AEDs. Inducer AEDs seem to have an opposite effect than the inhibitor VPA on plasma tHcy, erythrocyte folate and serum folate levels.

Authors+Show Affiliations

Department of Internal Medicine, The Central Hospital of Rogaland, Stavanger, Norway.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10770516

Citation

Apeland, T, et al. "Homocysteine Concentrations and Methionine Loading in Patients On Antiepileptic Drugs." Acta Neurologica Scandinavica, vol. 101, no. 4, 2000, pp. 217-23.
Apeland T, Mansoor MA, Strandjord RE, et al. Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. Acta Neurol Scand. 2000;101(4):217-23.
Apeland, T., Mansoor, M. A., Strandjord, R. E., & Kristensen, O. (2000). Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. Acta Neurologica Scandinavica, 101(4), pp. 217-23.
Apeland T, et al. Homocysteine Concentrations and Methionine Loading in Patients On Antiepileptic Drugs. Acta Neurol Scand. 2000;101(4):217-23. PubMed PMID: 10770516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. AU - Apeland,T, AU - Mansoor,M A, AU - Strandjord,R E, AU - Kristensen,O, PY - 2000/4/19/pubmed PY - 2000/6/17/medline PY - 2000/4/19/entrez SP - 217 EP - 23 JF - Acta neurologica Scandinavica JO - Acta Neurol. Scand. VL - 101 IS - 4 N2 - OBJECTIVES: A few reports have shown elevated fasting total plasma homocysteine (tHcy) in patients taking antiepileptic drugs (AEDs). In this study we determined the influence of AEDs on plasma tHcy levels prior to and following methionine loading. MATERIAL AND METHODS: Thirty-four patients on different AEDs and 34 matched controls were recruited. Blood samples were drawn prior to and 6 h post-methionine loading (6h-PML). RESULTS: The patients on AEDs inducing the cytochrome P450 (carbamazepine, phenytoin, phenobarbital, primidone), had higher fasting and 6h-PML plasma tHcy concentrations than the controls (P = 0.01 and P<0.001). Patients on AED inhibiting the cytochrome P450 (valproate [VPA]), had lower 6h-PML p-tHcy concentrations than controls (P = 0.01). CONCLUSIONS: Our data indicate that not only fasting but also 6h-PML tHcy levels should be determined in order to identify hyperhomocysteinemia among patients on AEDs. Inducer AEDs seem to have an opposite effect than the inhibitor VPA on plasma tHcy, erythrocyte folate and serum folate levels. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/10770516/Homocysteine_concentrations_and_methionine_loading_in_patients_on_antiepileptic_drugs_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0001-6314&amp;date=2000&amp;volume=101&amp;issue=4&amp;spage=217 DB - PRIME DP - Unbound Medicine ER -