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Silent myocardial ischemia and cardiac autonomic neuropathy in diabetics.
J Assoc Physicians India. 1999 Aug; 47(8):767-9.JA

Abstract

OBJECTIVE

To evaluate the association of silent myocardial ischemia (SMI) with cardiac autonomic neuropathy in asymptomatic diabetic patients.

MATERIAL AND METHODS

Two hundred asymptomatic patients of diabetes mellitus were assessed for evidence of cardiac autonomic neuropathy. Of these, 30 (15 males, 15 females; mean age 44.7 +/- 8.8 years) were found to have cardiac autonomic neuropathy. Thirty (30) age and sex matched diabetic patients (mean age 42.4 +/- 7.6 years) who had no evidence autonomic neuropathy were included in the study as control group. Both the groups of patients were evaluated for SMI by 24 hour ambulatory electrocardiographic (ECG) monitoring.

RESULTS

Incidence of SMI was significantly higher in patients with autonomic neuropathy 12/30 (40%) compared to those without 3/30 (10%) p < 0.001. Duration of diabetes was more (13 +/- 1.59 years) in patients with autonomic neuropathy compared to the control group (8.66 +/- 1.55 years) p < 0.001. Serum cholesterol and triglyceride levels were significantly higher in patients with autonomic neuropathy in comparison to control group < 0.05 and < 0.01, respectively. There was no difference in the pattern of SMI in the two groups (p = N.S).

CONCLUSION

Cardiac autonomic neuropathy predisposes patients with diabetes mellitus to SMI. Twenty four hour ambulatory ECG monitoring provides useful diagnostic information in early detection and evaluation of SMI in asymptomatic diabetic patients.

Authors+Show Affiliations

Jalal S
Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar.
Alai MS
No affiliation info available
Khan KA
No affiliation info available
Jan VM
No affiliation info available
Rather HA
No affiliation info available
Iqbal K
No affiliation info available
Tramboo NA
No affiliation info available
Lone NA
No affiliation info available
Dar MA
No affiliation info available
Hayat A
No affiliation info available
Abbas SM
No affiliation info available

MeSH

AdultAutonomic Nervous SystemAutonomic Nervous System DiseasesDiabetic NeuropathiesElectrocardiography, AmbulatoryFemaleHeartHumansMaleMiddle AgedMyocardial InfarctionMyocardial IschemiaRisk Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10778618

Citation

Jalal, S, et al. "Silent Myocardial Ischemia and Cardiac Autonomic Neuropathy in Diabetics." The Journal of the Association of Physicians of India, vol. 47, no. 8, 1999, pp. 767-9.
Jalal S, Alai MS, Khan KA, et al. Silent myocardial ischemia and cardiac autonomic neuropathy in diabetics. J Assoc Physicians India. 1999;47(8):767-9.
Jalal, S., Alai, M. S., Khan, K. A., Jan, V. M., Rather, H. A., Iqbal, K., Tramboo, N. A., Lone, N. A., Dar, M. A., Hayat, A., & Abbas, S. M. (1999). Silent myocardial ischemia and cardiac autonomic neuropathy in diabetics. The Journal of the Association of Physicians of India, 47(8), 767-9.
Jalal S, et al. Silent Myocardial Ischemia and Cardiac Autonomic Neuropathy in Diabetics. J Assoc Physicians India. 1999;47(8):767-9. PubMed PMID: 10778618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Silent myocardial ischemia and cardiac autonomic neuropathy in diabetics. AU - Jalal,S, AU - Alai,M S, AU - Khan,K A, AU - Jan,V M, AU - Rather,H A, AU - Iqbal,K, AU - Tramboo,N A, AU - Lone,N A, AU - Dar,M A, AU - Hayat,A, AU - Abbas,S M, PY - 2000/4/25/pubmed PY - 2000/5/20/medline PY - 2000/4/25/entrez SP - 767 EP - 9 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 47 IS - 8 N2 - OBJECTIVE: To evaluate the association of silent myocardial ischemia (SMI) with cardiac autonomic neuropathy in asymptomatic diabetic patients. MATERIAL AND METHODS: Two hundred asymptomatic patients of diabetes mellitus were assessed for evidence of cardiac autonomic neuropathy. Of these, 30 (15 males, 15 females; mean age 44.7 +/- 8.8 years) were found to have cardiac autonomic neuropathy. Thirty (30) age and sex matched diabetic patients (mean age 42.4 +/- 7.6 years) who had no evidence autonomic neuropathy were included in the study as control group. Both the groups of patients were evaluated for SMI by 24 hour ambulatory electrocardiographic (ECG) monitoring. RESULTS: Incidence of SMI was significantly higher in patients with autonomic neuropathy 12/30 (40%) compared to those without 3/30 (10%) p < 0.001. Duration of diabetes was more (13 +/- 1.59 years) in patients with autonomic neuropathy compared to the control group (8.66 +/- 1.55 years) p < 0.001. Serum cholesterol and triglyceride levels were significantly higher in patients with autonomic neuropathy in comparison to control group < 0.05 and < 0.01, respectively. There was no difference in the pattern of SMI in the two groups (p = N.S). CONCLUSION: Cardiac autonomic neuropathy predisposes patients with diabetes mellitus to SMI. Twenty four hour ambulatory ECG monitoring provides useful diagnostic information in early detection and evaluation of SMI in asymptomatic diabetic patients. SN - 0004-5772 UR - https://www.unboundmedicine.com/medline/citation/10778618/Silent_myocardial_ischemia_and_cardiac_autonomic_neuropathy_in_diabetics_ DB - PRIME DP - Unbound Medicine ER -