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Abnormalities in histamine pharmacodynamics in chronic urticaria.
Clin Exp Allergy 1993; 23(12):1015-20CE

Abstract

Histamine plays a key role in the pathogenesis of chronic urticaria (CU). The authors of this paper have studied the effects of ingested histamine in 25 patients with CU. A 120 mg dose of histamine, well-tolerated in the healthy subject, was instillated into the duodenum. Concomitantly, plasma histamine (H) levels and plasma and urinary methylhistamine (MH) levels were measured. Intraduodenal administration of histamine was responsible for the development of an attack of urticaria in 64% of patients, while control subjects were asymptomatic. Plasma histamine levels were significantly higher after digestive histamine challenge (DHC) in patients with CU compared with controls. An abnormal increase in plasma histamine was observed in 72% of them. Plasma MH exhibited the same kinetic behaviour with a usually delayed time-pattern. Urinary MH concentration was higher in patients presenting with early-onset urticaria during the first hour than in those with the late-onset type between 1 and 12 hr after DHC. The coefficient of methylation (plasma MH/MH+H) was not significantly different in patients presenting with an attack of urticaria following DHC and in other subjects. Urinary excretion of MH and urinary flow increased significantly in patients presenting with an attack of urticaria following DHC which corresponds to increased absorption of histamine during the 5-hr period following DHC and its role on excretion by the kidney via vasodilation which it induces. This study demonstrates the abnormal frequency of disturbances in the metabolism of exogenous histamine in patients with CU. Increased plasma H accounts for the abnormal passage of H across the intestinal barrier which can result either from intestinal hyperpermeability and/or a deficit in the enzymatic catabolism of histamine. The systems of methylation and urinary clearance of MH appear to be effective. It is thus postulated that there is a deficit in diamine oxidase (DAO) in the enterocyte. The lack of correlation between the kinetic behaviour of plasma H and the onset of urticaria draws attention to the extent of individual variability in skin reactivity to histamine.

Authors+Show Affiliations

Service de Médecine D, Immunologie Clinique et Allergologie, Centre Hospitalier Universitaire de Nancy, Hôpital de Brabois, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10779295

Citation

Kanny, G, et al. "Abnormalities in Histamine Pharmacodynamics in Chronic Urticaria." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 23, no. 12, 1993, pp. 1015-20.
Kanny G, Moneret-Vautrin DA, Schohn H, et al. Abnormalities in histamine pharmacodynamics in chronic urticaria. Clin Exp Allergy. 1993;23(12):1015-20.
Kanny, G., Moneret-Vautrin, D. A., Schohn, H., Feldman, L., Mallie, J. P., & Gueant, J. L. (1993). Abnormalities in histamine pharmacodynamics in chronic urticaria. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 23(12), pp. 1015-20.
Kanny G, et al. Abnormalities in Histamine Pharmacodynamics in Chronic Urticaria. Clin Exp Allergy. 1993;23(12):1015-20. PubMed PMID: 10779295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormalities in histamine pharmacodynamics in chronic urticaria. AU - Kanny,G, AU - Moneret-Vautrin,D A, AU - Schohn,H, AU - Feldman,L, AU - Mallie,J P, AU - Gueant,J L, PY - 1993/12/1/pubmed PY - 2000/6/24/medline PY - 1993/12/1/entrez SP - 1015 EP - 20 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 23 IS - 12 N2 - Histamine plays a key role in the pathogenesis of chronic urticaria (CU). The authors of this paper have studied the effects of ingested histamine in 25 patients with CU. A 120 mg dose of histamine, well-tolerated in the healthy subject, was instillated into the duodenum. Concomitantly, plasma histamine (H) levels and plasma and urinary methylhistamine (MH) levels were measured. Intraduodenal administration of histamine was responsible for the development of an attack of urticaria in 64% of patients, while control subjects were asymptomatic. Plasma histamine levels were significantly higher after digestive histamine challenge (DHC) in patients with CU compared with controls. An abnormal increase in plasma histamine was observed in 72% of them. Plasma MH exhibited the same kinetic behaviour with a usually delayed time-pattern. Urinary MH concentration was higher in patients presenting with early-onset urticaria during the first hour than in those with the late-onset type between 1 and 12 hr after DHC. The coefficient of methylation (plasma MH/MH+H) was not significantly different in patients presenting with an attack of urticaria following DHC and in other subjects. Urinary excretion of MH and urinary flow increased significantly in patients presenting with an attack of urticaria following DHC which corresponds to increased absorption of histamine during the 5-hr period following DHC and its role on excretion by the kidney via vasodilation which it induces. This study demonstrates the abnormal frequency of disturbances in the metabolism of exogenous histamine in patients with CU. Increased plasma H accounts for the abnormal passage of H across the intestinal barrier which can result either from intestinal hyperpermeability and/or a deficit in the enzymatic catabolism of histamine. The systems of methylation and urinary clearance of MH appear to be effective. It is thus postulated that there is a deficit in diamine oxidase (DAO) in the enterocyte. The lack of correlation between the kinetic behaviour of plasma H and the onset of urticaria draws attention to the extent of individual variability in skin reactivity to histamine. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/10779295/Abnormalities_in_histamine_pharmacodynamics_in_chronic_urticaria_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=1993&volume=23&issue=12&spage=1015 DB - PRIME DP - Unbound Medicine ER -