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Regional variation in plasminogen activator inhibitor-1 expression in adipose tissue from obese individuals.
Thromb Haemost 2000; 83(4):545-8TH

Abstract

High plasma plasminogen activator inhibitor-1 (PAI-1) activity is a frequent finding in obesity and adipose tissue has recently been suggested to be a source of circulating PAI-1 in humans. In the present study, differences in adipose tissue gene expression and protein secretion rate of PAI-1 between subcutaneous and visceral adipose tissue was analysed in specimens obtained from 22 obese individuals. The secretion rate of PAI-1 was two-fold higher in subcutaneous adipose tissue than in visceral adipose tissue (292 +/- 50 vs 138 +/- 24 ng PAI-1/10(7) cells, P <0.05). In accordance with the secretion data, subcutaneous adipose tissue contained about three-fold higher levels of PAI-1 mRNA than visceral adipose tissue (2.43 +/- 0.37 vs 0.81 +/- 0.12 attomole PAI-1 mRNA/microg total RNA, P <0.00). PAI-1 secretion from subcutaneous but not from visceral adipose tissue correlated significantly with cell size (r = 0.43, P<0.05). In summary, subcutaneous adipose tissue secreted greater amounts of PAI-1 and had a higher PAI-1 gene expression than visceral adipose tissue from the same obese individuals. Bearing in mind that subcutaneous adipose tissue is the largest fat depot these finding may be important for the coagulation abnormalities associated with obesity.

Authors+Show Affiliations

Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Institute, Stockholm, Sweden. Per.Eriksson@medks.ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10780314

Citation

Eriksson, P, et al. "Regional Variation in Plasminogen Activator Inhibitor-1 Expression in Adipose Tissue From Obese Individuals." Thrombosis and Haemostasis, vol. 83, no. 4, 2000, pp. 545-8.
Eriksson P, Van Harmelen V, Hoffstedt J, et al. Regional variation in plasminogen activator inhibitor-1 expression in adipose tissue from obese individuals. Thromb Haemost. 2000;83(4):545-8.
Eriksson, P., Van Harmelen, V., Hoffstedt, J., Lundquist, P., Vidal, H., Stemme, V., ... Reynisdottir, S. (2000). Regional variation in plasminogen activator inhibitor-1 expression in adipose tissue from obese individuals. Thrombosis and Haemostasis, 83(4), pp. 545-8.
Eriksson P, et al. Regional Variation in Plasminogen Activator Inhibitor-1 Expression in Adipose Tissue From Obese Individuals. Thromb Haemost. 2000;83(4):545-8. PubMed PMID: 10780314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regional variation in plasminogen activator inhibitor-1 expression in adipose tissue from obese individuals. AU - Eriksson,P, AU - Van Harmelen,V, AU - Hoffstedt,J, AU - Lundquist,P, AU - Vidal,H, AU - Stemme,V, AU - Hamsten,A, AU - Arner,P, AU - Reynisdottir,S, PY - 2000/4/26/pubmed PY - 2000/8/6/medline PY - 2000/4/26/entrez SP - 545 EP - 8 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 83 IS - 4 N2 - High plasma plasminogen activator inhibitor-1 (PAI-1) activity is a frequent finding in obesity and adipose tissue has recently been suggested to be a source of circulating PAI-1 in humans. In the present study, differences in adipose tissue gene expression and protein secretion rate of PAI-1 between subcutaneous and visceral adipose tissue was analysed in specimens obtained from 22 obese individuals. The secretion rate of PAI-1 was two-fold higher in subcutaneous adipose tissue than in visceral adipose tissue (292 +/- 50 vs 138 +/- 24 ng PAI-1/10(7) cells, P <0.05). In accordance with the secretion data, subcutaneous adipose tissue contained about three-fold higher levels of PAI-1 mRNA than visceral adipose tissue (2.43 +/- 0.37 vs 0.81 +/- 0.12 attomole PAI-1 mRNA/microg total RNA, P <0.00). PAI-1 secretion from subcutaneous but not from visceral adipose tissue correlated significantly with cell size (r = 0.43, P<0.05). In summary, subcutaneous adipose tissue secreted greater amounts of PAI-1 and had a higher PAI-1 gene expression than visceral adipose tissue from the same obese individuals. Bearing in mind that subcutaneous adipose tissue is the largest fat depot these finding may be important for the coagulation abnormalities associated with obesity. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/10780314/Regional_variation_in_plasminogen_activator_inhibitor_1_expression_in_adipose_tissue_from_obese_individuals_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -