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The sesquiterpene lactone dehydroleucodine (DhL) affects the growth of cultured epimastigotes of Trypanosoma cruzi.
J Parasitol. 2000 Apr; 86(2):407-12.JP

Abstract

Here, we report an inhibitory effect of a sesquiterpene lactone dehydroleucodine (DhL) on the growth of Trypanosoma cruzi in culture. At concentrations of the drug between 5 and 10 microg/ml in the medium,the parasites remained alive for at least 4 days. Higher concentrations of DhL were lethal for the parasites within a few hours. The effect of DhL is irreversible. Morphological changes induced by DhL were also observed in the parasites. The effect of DhL was blocked by the presence of reducing substrates such as glutathione or dithiothreitol, but these agents were not able to reverse the effect of DhL if added 2 days after the start of drug exposure.

Authors+Show Affiliations

Instituto de Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10780563

Citation

Brengio, S D., et al. "The Sesquiterpene Lactone Dehydroleucodine (DhL) Affects the Growth of Cultured Epimastigotes of Trypanosoma Cruzi." The Journal of Parasitology, vol. 86, no. 2, 2000, pp. 407-12.
Brengio SD, Belmonte SA, Guerreiro E, et al. The sesquiterpene lactone dehydroleucodine (DhL) affects the growth of cultured epimastigotes of Trypanosoma cruzi. J Parasitol. 2000;86(2):407-12.
Brengio, S. D., Belmonte, S. A., Guerreiro, E., Giordano, O. S., Pietrobon, E. O., & Sosa, M. A. (2000). The sesquiterpene lactone dehydroleucodine (DhL) affects the growth of cultured epimastigotes of Trypanosoma cruzi. The Journal of Parasitology, 86(2), 407-12.
Brengio SD, et al. The Sesquiterpene Lactone Dehydroleucodine (DhL) Affects the Growth of Cultured Epimastigotes of Trypanosoma Cruzi. J Parasitol. 2000;86(2):407-12. PubMed PMID: 10780563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The sesquiterpene lactone dehydroleucodine (DhL) affects the growth of cultured epimastigotes of Trypanosoma cruzi. AU - Brengio,S D, AU - Belmonte,S A, AU - Guerreiro,E, AU - Giordano,O S, AU - Pietrobon,E O, AU - Sosa,M A, PY - 2000/4/26/pubmed PY - 2000/4/29/medline PY - 2000/4/26/entrez SP - 407 EP - 12 JF - The Journal of parasitology JO - J Parasitol VL - 86 IS - 2 N2 - Here, we report an inhibitory effect of a sesquiterpene lactone dehydroleucodine (DhL) on the growth of Trypanosoma cruzi in culture. At concentrations of the drug between 5 and 10 microg/ml in the medium,the parasites remained alive for at least 4 days. Higher concentrations of DhL were lethal for the parasites within a few hours. The effect of DhL is irreversible. Morphological changes induced by DhL were also observed in the parasites. The effect of DhL was blocked by the presence of reducing substrates such as glutathione or dithiothreitol, but these agents were not able to reverse the effect of DhL if added 2 days after the start of drug exposure. SN - 0022-3395 UR - https://www.unboundmedicine.com/medline/citation/10780563/The_sesquiterpene_lactone_dehydroleucodine__DhL__affects_the_growth_of_cultured_epimastigotes_of_Trypanosoma_cruzi_ L2 - https://doi.org/10.1645/0022-3395(2000)086[0407:TSLDDA]2.0.CO;2 DB - PRIME DP - Unbound Medicine ER -