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Pharmacologic modulation of motility.
Yale J Biol Med 1999 Mar-Jun; 72(2-3):173-80YJ

Abstract

Etiologically, gastroesophageal reflux disease (GERD) can be regarded as motility disorder: Although blocking acid is effective in the treatment of GERD, it does not overcome the underlying pathologic factors that allow acid, pepsin, and bile to reflux into the esophagus. Prokinetic agents address the upper gastrointestinal motility disturbances contributing to GERD and, thus, have an important role in the short- and long-term medical management of reflux esophagitis. This paper discusses the rationale for the effectiveness of pharmacologic modulation by reviewing current concepts and postulated theories about the mechanisms underlying the neuromuscular abnormalities. The multifactorial aspects of GERD are addressed and the potential for tailoring medical therapy also emphasized.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Center for GI Motility Disorders, University of Kansas Medical Center, Kansas City 66160, USA. rmccalu@kumc.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10780579

Citation

McCallum, R W.. "Pharmacologic Modulation of Motility." The Yale Journal of Biology and Medicine, vol. 72, no. 2-3, 1999, pp. 173-80.
McCallum RW. Pharmacologic modulation of motility. Yale J Biol Med. 1999;72(2-3):173-80.
McCallum, R. W. (1999). Pharmacologic modulation of motility. The Yale Journal of Biology and Medicine, 72(2-3), pp. 173-80.
McCallum RW. Pharmacologic Modulation of Motility. Yale J Biol Med. 1999;72(2-3):173-80. PubMed PMID: 10780579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacologic modulation of motility. A1 - McCallum,R W, PY - 2000/4/26/pubmed PY - 2000/5/20/medline PY - 2000/4/26/entrez SP - 173 EP - 80 JF - The Yale journal of biology and medicine JO - Yale J Biol Med VL - 72 IS - 2-3 N2 - Etiologically, gastroesophageal reflux disease (GERD) can be regarded as motility disorder: Although blocking acid is effective in the treatment of GERD, it does not overcome the underlying pathologic factors that allow acid, pepsin, and bile to reflux into the esophagus. Prokinetic agents address the upper gastrointestinal motility disturbances contributing to GERD and, thus, have an important role in the short- and long-term medical management of reflux esophagitis. This paper discusses the rationale for the effectiveness of pharmacologic modulation by reviewing current concepts and postulated theories about the mechanisms underlying the neuromuscular abnormalities. The multifactorial aspects of GERD are addressed and the potential for tailoring medical therapy also emphasized. SN - 0044-0086 UR - https://www.unboundmedicine.com/medline/citation/10780579/Pharmacologic_modulation_of_motility_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/10780579/ DB - PRIME DP - Unbound Medicine ER -