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Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland)
Cancer Causes Control 2000; 11(3):197-205CC

Abstract

BACKGROUND

Some epidemiological investigations suggest that higher intake or biochemical status of vitamin E and beta-carotene might be associated with reduced risk of colorectal cancer.

METHODS

We tested the effects of alpha-tocopherol and beta-carotene supplementation on the incidence of colorectal cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, a double-blind, placebo-controlled trial among 29,133 50-69-year-old male cigarette smokers. Participants were randomly assigned to receive alpha-tocopherol (50 mg), beta-carotene (20 mg), both agents, or a placebo daily for 5-8 years. Incident colorectal cancers (n = 135) were identified through the nationwide cancer registry, and 99% were histologically confirmed. Intervention effects were evaluated using survival analysis and proportional hazards models.

RESULTS

Colorectal cancer incidence was somewhat lower in the alpha-tocopherol arm compared to the no alpha-tocopherol arm, but this finding was not statistically significant (relative risk (RR) = 0.78, 95% confidence interval (CI) 0.55-1.09; log-rank test p = 0.15). Beta-carotene had no effect on colorectal cancer incidence (RR = 1.05, 95% CI 0.75-1.47; log-rank test p = 0.78). There was no interaction between the two substances.

CONCLUSION

Our study found no evidence of a beneficial or harmful effect for beta-carotene in colorectal cancer in older male smokers, but does provide suggestive evidence that vitamin E supplementation may have had a modest preventive effect. The latter finding is in accord with previous research linking higher vitamin E status to reduced colorectal cancer risk.

Authors+Show Affiliations

Division of Clinical Sciences, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10782653

Citation

Albanes, D, et al. "Effects of Supplemental Alpha-tocopherol and Beta-carotene On Colorectal Cancer: Results From a Controlled Trial (Finland)." Cancer Causes & Control : CCC, vol. 11, no. 3, 2000, pp. 197-205.
Albanes D, Malila N, Taylor PR, et al. Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland). Cancer Causes Control. 2000;11(3):197-205.
Albanes, D., Malila, N., Taylor, P. R., Huttunen, J. K., Virtamo, J., Edwards, B. K., ... Heinonen, O. P. (2000). Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland). Cancer Causes & Control : CCC, 11(3), pp. 197-205.
Albanes D, et al. Effects of Supplemental Alpha-tocopherol and Beta-carotene On Colorectal Cancer: Results From a Controlled Trial (Finland). Cancer Causes Control. 2000;11(3):197-205. PubMed PMID: 10782653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland) AU - Albanes,D, AU - Malila,N, AU - Taylor,P R, AU - Huttunen,J K, AU - Virtamo,J, AU - Edwards,B K, AU - Rautalahti,M, AU - Hartman,A M, AU - Barrett,M J, AU - Pietinen,P, AU - Hartman,T J, AU - Sipponen,P, AU - Lewin,K, AU - Teerenhovi,L, AU - Hietanen,P, AU - Tangrea,J A, AU - Virtanen,M, AU - Heinonen,O P, PY - 2000/4/27/pubmed PY - 2000/7/6/medline PY - 2000/4/27/entrez SP - 197 EP - 205 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 11 IS - 3 N2 - BACKGROUND: Some epidemiological investigations suggest that higher intake or biochemical status of vitamin E and beta-carotene might be associated with reduced risk of colorectal cancer. METHODS: We tested the effects of alpha-tocopherol and beta-carotene supplementation on the incidence of colorectal cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, a double-blind, placebo-controlled trial among 29,133 50-69-year-old male cigarette smokers. Participants were randomly assigned to receive alpha-tocopherol (50 mg), beta-carotene (20 mg), both agents, or a placebo daily for 5-8 years. Incident colorectal cancers (n = 135) were identified through the nationwide cancer registry, and 99% were histologically confirmed. Intervention effects were evaluated using survival analysis and proportional hazards models. RESULTS: Colorectal cancer incidence was somewhat lower in the alpha-tocopherol arm compared to the no alpha-tocopherol arm, but this finding was not statistically significant (relative risk (RR) = 0.78, 95% confidence interval (CI) 0.55-1.09; log-rank test p = 0.15). Beta-carotene had no effect on colorectal cancer incidence (RR = 1.05, 95% CI 0.75-1.47; log-rank test p = 0.78). There was no interaction between the two substances. CONCLUSION: Our study found no evidence of a beneficial or harmful effect for beta-carotene in colorectal cancer in older male smokers, but does provide suggestive evidence that vitamin E supplementation may have had a modest preventive effect. The latter finding is in accord with previous research linking higher vitamin E status to reduced colorectal cancer risk. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/10782653/Effects_of_supplemental_alpha_tocopherol_and_beta_carotene_on_colorectal_cancer:_results_from_a_controlled_trial__Finland_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10782653.ui DB - PRIME DP - Unbound Medicine ER -