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Hair analysis: self-reported use of "speed" and "ecstasy" compared with laboratory findings.
J Forensic Sci. 2000 Mar; 45(2):400-6.JF

Abstract

Drug use histories were collected from 100 subjects recruited from the "dance scene" in and around Glasgow, Scotland. In addition, each subject donated a hair sample which was analyzed by gas chromatography/mass spectrometry (GC/MS) for amphetamine (AP), methamphetamine (MA), 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MD MA) and 3,4-methylenedioxyethylamphetamine (MDEA). The hair samples were analyzed in two 6 cm segments or in full, ranging from 1.5 to 12 cm depending on the length of the hair. Approximately 10 mg of hair was ground to a fine powder before treatment with beta-glucuronidase/aryl sulfatase. A solid-phase extraction procedure was carried out followed by derivatization with pentafluoropropionic anhydride (PFPA). All extracts were analyzed by gas chromatography/mass spectrometry (GC/MS). Of the 139 segments analyzed, 77 (52.5%) were positive for at least one of the five amphetamines. The drug concentrations found in the hair were compared with the self-reported drug histories. A concordance of greater than 50% was found between the self-report data and levels detected in hair. However, no correlation was found between the reported number of "ecstasy" tablets consumed and the drug levels detected in hair. An increase in the average drug levels measured was observed from low to high use (number of "ecstasy" tablets/month). A large number of false negatives and a low number of false positives were observed.

Authors+Show Affiliations

Department of Forensic Medicine and Science, University of Glasgow, Scotland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10782961

Citation

Cooper, G A., et al. "Hair Analysis: Self-reported Use of "speed" and "ecstasy" Compared With Laboratory Findings." Journal of Forensic Sciences, vol. 45, no. 2, 2000, pp. 400-6.
Cooper GA, Allen DL, Scott KS, et al. Hair analysis: self-reported use of "speed" and "ecstasy" compared with laboratory findings. J Forensic Sci. 2000;45(2):400-6.
Cooper, G. A., Allen, D. L., Scott, K. S., Oliver, J. S., Ditton, J., & Smith, I. D. (2000). Hair analysis: self-reported use of "speed" and "ecstasy" compared with laboratory findings. Journal of Forensic Sciences, 45(2), 400-6.
Cooper GA, et al. Hair Analysis: Self-reported Use of "speed" and "ecstasy" Compared With Laboratory Findings. J Forensic Sci. 2000;45(2):400-6. PubMed PMID: 10782961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hair analysis: self-reported use of "speed" and "ecstasy" compared with laboratory findings. AU - Cooper,G A, AU - Allen,D L, AU - Scott,K S, AU - Oliver,J S, AU - Ditton,J, AU - Smith,I D, PY - 2000/4/27/pubmed PY - 2000/6/17/medline PY - 2000/4/27/entrez SP - 400 EP - 6 JF - Journal of forensic sciences JO - J. Forensic Sci. VL - 45 IS - 2 N2 - Drug use histories were collected from 100 subjects recruited from the "dance scene" in and around Glasgow, Scotland. In addition, each subject donated a hair sample which was analyzed by gas chromatography/mass spectrometry (GC/MS) for amphetamine (AP), methamphetamine (MA), 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MD MA) and 3,4-methylenedioxyethylamphetamine (MDEA). The hair samples were analyzed in two 6 cm segments or in full, ranging from 1.5 to 12 cm depending on the length of the hair. Approximately 10 mg of hair was ground to a fine powder before treatment with beta-glucuronidase/aryl sulfatase. A solid-phase extraction procedure was carried out followed by derivatization with pentafluoropropionic anhydride (PFPA). All extracts were analyzed by gas chromatography/mass spectrometry (GC/MS). Of the 139 segments analyzed, 77 (52.5%) were positive for at least one of the five amphetamines. The drug concentrations found in the hair were compared with the self-reported drug histories. A concordance of greater than 50% was found between the self-report data and levels detected in hair. However, no correlation was found between the reported number of "ecstasy" tablets consumed and the drug levels detected in hair. An increase in the average drug levels measured was observed from low to high use (number of "ecstasy" tablets/month). A large number of false negatives and a low number of false positives were observed. SN - 0022-1198 UR - https://www.unboundmedicine.com/medline/citation/10782961/Hair_analysis:_self_reported_use_of_"speed"_and_"ecstasy"_compared_with_laboratory_findings_ L2 - https://medlineplus.gov/clubdrugs.html DB - PRIME DP - Unbound Medicine ER -