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Obstetric risk factors for early-onset schizophrenia in a Finnish birth cohort.
Am J Psychiatry 2000; 157(5):801-7AJ

Abstract

OBJECTIVE

Although case-control investigations have shown an association between obstetric complications and schizophrenia, particularly among patients with early onsets, cohort studies have mostly failed to confirm this effect. The authors examined whether a history of fetal hypoxia and other obstetric complications elevated risk for early-onset schizophrenia in a 1955 Helsinki birth cohort.

METHOD

The subjects were 80 randomly selected patients with schizophrenia (36 with early and 44 with later onsets) representative of all available probands in the cohort, 61 of their nonschizophrenic siblings, and 56 demographically matched nonpsychiatric comparison subjects. Psychiatric diagnoses were obtained from structured clinical interviews, and obstetric data were taken from standardized, prospectively ascertained obstetric records. A score for hypoxia-associated obstetric complications was entered into logistic regression models, along with measures of prenatal infection and fetal growth retardation.

RESULTS

Hypoxia-associated obstetric complications significantly increased the odds of early-onset schizophrenia but not of later-onset schizophrenia or unaffected sibling status, after prenatal infection and fetal growth retardation were taken into account.

CONCLUSIONS

These findings support an association between obstetric complications and increased risk for early-onset schizophrenia. The authors advance a model whereby the neurotoxic effects of fetal hypoxia may lead to an early onset of schizophrenia due to premature cortical synaptic pruning.

Authors+Show Affiliations

Department of Psychology, University of Pennsylvania, Philadelphia, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10784475

Citation

Rosso, I M., et al. "Obstetric Risk Factors for Early-onset Schizophrenia in a Finnish Birth Cohort." The American Journal of Psychiatry, vol. 157, no. 5, 2000, pp. 801-7.
Rosso IM, Cannon TD, Huttunen T, et al. Obstetric risk factors for early-onset schizophrenia in a Finnish birth cohort. Am J Psychiatry. 2000;157(5):801-7.
Rosso, I. M., Cannon, T. D., Huttunen, T., Huttunen, M. O., Lönnqvist, J., & Gasperoni, T. L. (2000). Obstetric risk factors for early-onset schizophrenia in a Finnish birth cohort. The American Journal of Psychiatry, 157(5), pp. 801-7.
Rosso IM, et al. Obstetric Risk Factors for Early-onset Schizophrenia in a Finnish Birth Cohort. Am J Psychiatry. 2000;157(5):801-7. PubMed PMID: 10784475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obstetric risk factors for early-onset schizophrenia in a Finnish birth cohort. AU - Rosso,I M, AU - Cannon,T D, AU - Huttunen,T, AU - Huttunen,M O, AU - Lönnqvist,J, AU - Gasperoni,T L, PY - 2000/4/28/pubmed PY - 2000/5/20/medline PY - 2000/4/28/entrez SP - 801 EP - 7 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 157 IS - 5 N2 - OBJECTIVE: Although case-control investigations have shown an association between obstetric complications and schizophrenia, particularly among patients with early onsets, cohort studies have mostly failed to confirm this effect. The authors examined whether a history of fetal hypoxia and other obstetric complications elevated risk for early-onset schizophrenia in a 1955 Helsinki birth cohort. METHOD: The subjects were 80 randomly selected patients with schizophrenia (36 with early and 44 with later onsets) representative of all available probands in the cohort, 61 of their nonschizophrenic siblings, and 56 demographically matched nonpsychiatric comparison subjects. Psychiatric diagnoses were obtained from structured clinical interviews, and obstetric data were taken from standardized, prospectively ascertained obstetric records. A score for hypoxia-associated obstetric complications was entered into logistic regression models, along with measures of prenatal infection and fetal growth retardation. RESULTS: Hypoxia-associated obstetric complications significantly increased the odds of early-onset schizophrenia but not of later-onset schizophrenia or unaffected sibling status, after prenatal infection and fetal growth retardation were taken into account. CONCLUSIONS: These findings support an association between obstetric complications and increased risk for early-onset schizophrenia. The authors advance a model whereby the neurotoxic effects of fetal hypoxia may lead to an early onset of schizophrenia due to premature cortical synaptic pruning. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/10784475/Obstetric_risk_factors_for_early_onset_schizophrenia_in_a_Finnish_birth_cohort_ L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.157.5.801?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -