Abstract
OBJECTIVE
To compare the long-term (1 year) effects of flutamide (250 mg/d) and finasteride (5 mg/d) for the treatment of hirsutism in women.
DESIGN
Randomized, prospective clinical study.
SETTING
Departments of Gynecology and Obstetrics and Endocrinology at Erciyes University Medical Faculty, Kayseri, Turkey.
PATIENT(S)
Seventy patients with hirsutism were studied.
INTERVENTION(S)
Thirty-five patients were treated with flutamide (250 mg/d) and 35 patients with finasteride (5 mg/d) for 12 months. Hirsutism score, hormone levels, and multiscreen blood chemistry were measured at 3-month intervals.
MAIN OUTCOME MEASURE(S)
Reduction in hair growth.
RESULT(S)
The modified Ferriman-Gallwey scores for hirsutism decreased significantly at months 6 and 12 from a mean +/- SD of 17. 8 +/- 5.8 to 6.0 +/- 3.4 and 17.8 +/- 5.8 to 4.8 +/- 3.2, respectively, in group 1; and from 19.1 +/- 6.1 to 14.2 +/- 4.9 and 19.1 +/- 6.1 to 11.3 +/- 5.0 in group 2, respectively. There were no statistically significant differences in any of the hormonal indices in group 1, but in group 2, E(2) and sex hormone-binding globulin increased significantly while DHEAS decreased significantly at 12 months of therapy.
CONCLUSION(S)
This study shows that flutamide (250 mg/d) is more effective than finasteride (5 mg/d) in reducing hair growth. We conclude that flutamide (250 mg/d) may represent a more effective and well tolerated treatment for patients.
TY - JOUR
T1 - A prospective, randomized trial comparing flutamide (250 mg/d) and finasteride (5 mg/d) in the treatment of hirsutism.
AU - Müderris,I I,
AU - Bayram,F,
AU - Güven,M,
PY - 2000/4/28/pubmed
PY - 2000/6/24/medline
PY - 2000/4/28/entrez
SP - 984
EP - 7
JF - Fertility and sterility
JO - Fertil Steril
VL - 73
IS - 5
N2 - OBJECTIVE: To compare the long-term (1 year) effects of flutamide (250 mg/d) and finasteride (5 mg/d) for the treatment of hirsutism in women. DESIGN: Randomized, prospective clinical study. SETTING: Departments of Gynecology and Obstetrics and Endocrinology at Erciyes University Medical Faculty, Kayseri, Turkey. PATIENT(S): Seventy patients with hirsutism were studied. INTERVENTION(S): Thirty-five patients were treated with flutamide (250 mg/d) and 35 patients with finasteride (5 mg/d) for 12 months. Hirsutism score, hormone levels, and multiscreen blood chemistry were measured at 3-month intervals. MAIN OUTCOME MEASURE(S): Reduction in hair growth. RESULT(S): The modified Ferriman-Gallwey scores for hirsutism decreased significantly at months 6 and 12 from a mean +/- SD of 17. 8 +/- 5.8 to 6.0 +/- 3.4 and 17.8 +/- 5.8 to 4.8 +/- 3.2, respectively, in group 1; and from 19.1 +/- 6.1 to 14.2 +/- 4.9 and 19.1 +/- 6.1 to 11.3 +/- 5.0 in group 2, respectively. There were no statistically significant differences in any of the hormonal indices in group 1, but in group 2, E(2) and sex hormone-binding globulin increased significantly while DHEAS decreased significantly at 12 months of therapy. CONCLUSION(S): This study shows that flutamide (250 mg/d) is more effective than finasteride (5 mg/d) in reducing hair growth. We conclude that flutamide (250 mg/d) may represent a more effective and well tolerated treatment for patients.
SN - 0015-0282
UR - https://www.unboundmedicine.com/medline/citation/10785225/A_prospective_randomized_trial_comparing_flutamide__250_mg/d__and_finasteride__5_mg/d__in_the_treatment_of_hirsutism_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(00)00470-2
DB - PRIME
DP - Unbound Medicine
ER -
