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Risk of cutaneous malignant melanoma in relation to use of sunbeds: further evidence for UV-A carcinogenicity.

Abstract

In a population-based, matched, case-control study from southern Sweden of 571 patients with a first diagnosis of cutaneous malignant melanoma and 913 healthy controls aged 16-80 years, the association between sunbed use and malignant melanoma was evaluated. A total of 250 (44%) cases and 372 (41%) controls reported ever having used sunbeds. A significantly elevated odds ratio for developing malignant melanoma after regular exposure to sunbeds was found, adjusted for hair colour, raised naevi, skin type and number of sunburns (odds ratio (OR) 1.8, 95% confidence interval (CI) 1.2-2.7). A dose-response relationship between total number of sunbed uses and melanoma risk was only found up to the level of 250 times. The OR was higher in individuals younger than age 36 years (adjusted OR 8.1, 95% CI 1.3-49.5 for regular vs. never use). The association seemed to be true only for subjects with black/dark brown or light brown hair and among females. Lesions of the extremities showed the strongest association of increased risk with sunbed use. An increased risk was related to commercial exposure and to exposure during the winter. The results substantiate the hypothesis that exposure to sunbeds might increase the risk of developing malignant melanoma.

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  • Authors+Show Affiliations

    ,

    Department of Surgery, University Hospital, Lund, Sweden.

    , , ,

    Source

    British journal of cancer 82:9 2000 May pg 1593-9

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Confidence Intervals
    Female
    Heliotherapy
    Humans
    Male
    Melanoma
    Middle Aged
    Neoplasms, Radiation-Induced
    Odds Ratio
    Skin Neoplasms
    Surveys and Questionnaires
    Ultraviolet Rays

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10789730

    Citation

    Westerdahl, J, et al. "Risk of Cutaneous Malignant Melanoma in Relation to Use of Sunbeds: Further Evidence for UV-A Carcinogenicity." British Journal of Cancer, vol. 82, no. 9, 2000, pp. 1593-9.
    Westerdahl J, Ingvar C, Måsbäck A, et al. Risk of cutaneous malignant melanoma in relation to use of sunbeds: further evidence for UV-A carcinogenicity. Br J Cancer. 2000;82(9):1593-9.
    Westerdahl, J., Ingvar, C., Måsbäck, A., Jonsson, N., & Olsson, H. (2000). Risk of cutaneous malignant melanoma in relation to use of sunbeds: further evidence for UV-A carcinogenicity. British Journal of Cancer, 82(9), pp. 1593-9.
    Westerdahl J, et al. Risk of Cutaneous Malignant Melanoma in Relation to Use of Sunbeds: Further Evidence for UV-A Carcinogenicity. Br J Cancer. 2000;82(9):1593-9. PubMed PMID: 10789730.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Risk of cutaneous malignant melanoma in relation to use of sunbeds: further evidence for UV-A carcinogenicity. AU - Westerdahl,J, AU - Ingvar,C, AU - Måsbäck,A, AU - Jonsson,N, AU - Olsson,H, PY - 2000/5/2/pubmed PY - 2000/5/20/medline PY - 2000/5/2/entrez SP - 1593 EP - 9 JF - British journal of cancer JO - Br. J. Cancer VL - 82 IS - 9 N2 - In a population-based, matched, case-control study from southern Sweden of 571 patients with a first diagnosis of cutaneous malignant melanoma and 913 healthy controls aged 16-80 years, the association between sunbed use and malignant melanoma was evaluated. A total of 250 (44%) cases and 372 (41%) controls reported ever having used sunbeds. A significantly elevated odds ratio for developing malignant melanoma after regular exposure to sunbeds was found, adjusted for hair colour, raised naevi, skin type and number of sunburns (odds ratio (OR) 1.8, 95% confidence interval (CI) 1.2-2.7). A dose-response relationship between total number of sunbed uses and melanoma risk was only found up to the level of 250 times. The OR was higher in individuals younger than age 36 years (adjusted OR 8.1, 95% CI 1.3-49.5 for regular vs. never use). The association seemed to be true only for subjects with black/dark brown or light brown hair and among females. Lesions of the extremities showed the strongest association of increased risk with sunbed use. An increased risk was related to commercial exposure and to exposure during the winter. The results substantiate the hypothesis that exposure to sunbeds might increase the risk of developing malignant melanoma. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/10789730/Risk_of_cutaneous_malignant_melanoma_in_relation_to_use_of_sunbeds:_further_evidence_for_UV_A_carcinogenicity_ L2 - http://dx.doi.org/10.1054/bjoc.1999.1181 DB - PRIME DP - Unbound Medicine ER -