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Clinical course of postinfectious bronchiolitis obliterans.
Pediatr Pulmonol 2000; 29(5):341-50PP

Abstract

We performed a prospective observational study to define the clinical course and the prognostic factors of 31 patients with postinfectious bronchiolitis obliterans. All patients presented with an episode of acute bronchiolitis in the first 2 years of life, and respiratory symptoms and signs persisted since then. Other diseases which may cause chronic airflow obstruction were excluded. The patients were followed after their inclusion in the study and the clinical findings were recorded in a standardized questionnaire and form. Repeated chest radiographs and lung perfusion scans were obtained in all 31 patients and semiannual spirometry was performed in 8 older patients. Eight patients had lung biopsies. The clinical course varied in the 31 patients during a mean of 3.5 years of follow-up. The outcome of the patients included clinical remission (22.6%), persistence of respiratory symptoms and signs (67.7%), and death (9.7%). An older age at onset of illness and presence of atopy as suggested by an elevated serum IgE appeared to predispose to a poor prognosis.

Authors+Show Affiliations

Departamento Materno-Infantil, Fundacao Universidade do Rio Grande, Rio Grande, Brazil. zhang@rgd.conesul.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10790245

Citation

Zhang, L, et al. "Clinical Course of Postinfectious Bronchiolitis Obliterans." Pediatric Pulmonology, vol. 29, no. 5, 2000, pp. 341-50.
Zhang L, Irion K, Kozakewich H, et al. Clinical course of postinfectious bronchiolitis obliterans. Pediatr Pulmonol. 2000;29(5):341-50.
Zhang, L., Irion, K., Kozakewich, H., Reid, L., Camargo, J. J., da Silva Porto, N., & Abreu e Silva, F. A. (2000). Clinical course of postinfectious bronchiolitis obliterans. Pediatric Pulmonology, 29(5), pp. 341-50.
Zhang L, et al. Clinical Course of Postinfectious Bronchiolitis Obliterans. Pediatr Pulmonol. 2000;29(5):341-50. PubMed PMID: 10790245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical course of postinfectious bronchiolitis obliterans. AU - Zhang,L, AU - Irion,K, AU - Kozakewich,H, AU - Reid,L, AU - Camargo,J J, AU - da Silva Porto,N, AU - Abreu e Silva,F A, PY - 2000/5/2/pubmed PY - 2000/7/6/medline PY - 2000/5/2/entrez SP - 341 EP - 50 JF - Pediatric pulmonology JO - Pediatr. Pulmonol. VL - 29 IS - 5 N2 - We performed a prospective observational study to define the clinical course and the prognostic factors of 31 patients with postinfectious bronchiolitis obliterans. All patients presented with an episode of acute bronchiolitis in the first 2 years of life, and respiratory symptoms and signs persisted since then. Other diseases which may cause chronic airflow obstruction were excluded. The patients were followed after their inclusion in the study and the clinical findings were recorded in a standardized questionnaire and form. Repeated chest radiographs and lung perfusion scans were obtained in all 31 patients and semiannual spirometry was performed in 8 older patients. Eight patients had lung biopsies. The clinical course varied in the 31 patients during a mean of 3.5 years of follow-up. The outcome of the patients included clinical remission (22.6%), persistence of respiratory symptoms and signs (67.7%), and death (9.7%). An older age at onset of illness and presence of atopy as suggested by an elevated serum IgE appeared to predispose to a poor prognosis. SN - 8755-6863 UR - https://www.unboundmedicine.com/medline/citation/10790245/Clinical_course_of_postinfectious_bronchiolitis_obliterans_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=8755-6863&date=2000&volume=29&issue=5&spage=341 DB - PRIME DP - Unbound Medicine ER -