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Sickle cell anemia: a potential nutritional approach for a molecular disease.
Nutrition 2000; 16(5):330-8N

Abstract

A certain population of red blood cells in patients with sickle cell anemia has an elevated density and possesses an abnormal membrane. These "dense cells" have a tendency to adhere to neutrophils, platelets, and vascular endothelial cells, and, thus, they could trigger vasoocclusion and the subsequent painful crisis from which these patients suffer. We developed a laboratory method of preparing such dense cells and found that nutritional antioxidant supplements, hydroxyl radical scavengers, and iron-binding agents could inhibit the formation of dense cells in vitro. The concentrations at which effective nutritional supplements could inhibit dense cell formation by 50% were 4.0 mg/mL for aged garlic extract, 0.38 mg/mL for black tea extract, 0.13 mg/mL for green tea extract, 0.07 mg/mL for Pycnogenol, 930 microM for alpha-lipoic acid, 270 microM for vitamin E, 45 microM for coenzyme Q(10), and 32 microM for beta-carotene. Both an ex vivo study and a pilot clinical trial demonstrated that a cocktail consisting of daily doses of 6 g of aged garlic extract, 4-6 g of vitamin C, and 800 to 1200 IU of vitamin E may indeed be beneficial to the patients.

Authors+Show Affiliations

Philadelphia Biomedical Research Institute, King of Prussia, Pennsylvania 19406, USA. stohnishi@aol.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10793299

Citation

Ohnishi, S T., et al. "Sickle Cell Anemia: a Potential Nutritional Approach for a Molecular Disease." Nutrition (Burbank, Los Angeles County, Calif.), vol. 16, no. 5, 2000, pp. 330-8.
Ohnishi ST, Ohnishi T, Ogunmola GB. Sickle cell anemia: a potential nutritional approach for a molecular disease. Nutrition. 2000;16(5):330-8.
Ohnishi, S. T., Ohnishi, T., & Ogunmola, G. B. (2000). Sickle cell anemia: a potential nutritional approach for a molecular disease. Nutrition (Burbank, Los Angeles County, Calif.), 16(5), pp. 330-8.
Ohnishi ST, Ohnishi T, Ogunmola GB. Sickle Cell Anemia: a Potential Nutritional Approach for a Molecular Disease. Nutrition. 2000;16(5):330-8. PubMed PMID: 10793299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sickle cell anemia: a potential nutritional approach for a molecular disease. AU - Ohnishi,S T, AU - Ohnishi,T, AU - Ogunmola,G B, PY - 2000/5/4/pubmed PY - 2000/7/8/medline PY - 2000/5/4/entrez SP - 330 EP - 8 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 16 IS - 5 N2 - A certain population of red blood cells in patients with sickle cell anemia has an elevated density and possesses an abnormal membrane. These "dense cells" have a tendency to adhere to neutrophils, platelets, and vascular endothelial cells, and, thus, they could trigger vasoocclusion and the subsequent painful crisis from which these patients suffer. We developed a laboratory method of preparing such dense cells and found that nutritional antioxidant supplements, hydroxyl radical scavengers, and iron-binding agents could inhibit the formation of dense cells in vitro. The concentrations at which effective nutritional supplements could inhibit dense cell formation by 50% were 4.0 mg/mL for aged garlic extract, 0.38 mg/mL for black tea extract, 0.13 mg/mL for green tea extract, 0.07 mg/mL for Pycnogenol, 930 microM for alpha-lipoic acid, 270 microM for vitamin E, 45 microM for coenzyme Q(10), and 32 microM for beta-carotene. Both an ex vivo study and a pilot clinical trial demonstrated that a cocktail consisting of daily doses of 6 g of aged garlic extract, 4-6 g of vitamin C, and 800 to 1200 IU of vitamin E may indeed be beneficial to the patients. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/10793299/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(00)00257-4 DB - PRIME DP - Unbound Medicine ER -