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Microglia, amyloid and dementia in alzheimer disease. A correlative study.
Neurobiol Aging 2000 Jan-Feb; 21(1):39-47NA

Abstract

To elucidate the role of microglia in Alzheimer's disease, a clinicopathological study was performed involving 26 cases, the mental status of which had been studied pre mortem by the Blessed test score (BTS). We measured the volume density of CD 68 immunoreactive (IR) microglia, congophilic plaques and Abeta deposits, and the numerical density of neurofibrillary tangles (NFT) in a sample of Area 9 (middle frontal gyrus). Dementia was significantly correlated only with the volume density of Abeta deposits and the numerical density of NFT. The volume densities of microglia and congophilic plaques were strongly correlated. With the intellectual status used as a time scale, IR microglia and amyloid deposits appeared almost simultaneously at an early stage in the pathological cascade and decreased, whereas Abeta and NFT were still accumulating. The intellectual deficit seemed to be more significantly related to the latter two lesions than to the microglia-amyloid complex, that was visible at an earlier stage (around BTS = 15).

Authors+Show Affiliations

Neurosciences Research Institute, Amsterdam Free University, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10794847

Citation

Arends, Y M., et al. "Microglia, Amyloid and Dementia in Alzheimer Disease. a Correlative Study." Neurobiology of Aging, vol. 21, no. 1, 2000, pp. 39-47.
Arends YM, Duyckaerts C, Rozemuller JM, et al. Microglia, amyloid and dementia in alzheimer disease. A correlative study. Neurobiol Aging. 2000;21(1):39-47.
Arends, Y. M., Duyckaerts, C., Rozemuller, J. M., Eikelenboom, P., & Hauw, J. J. (2000). Microglia, amyloid and dementia in alzheimer disease. A correlative study. Neurobiology of Aging, 21(1), pp. 39-47.
Arends YM, et al. Microglia, Amyloid and Dementia in Alzheimer Disease. a Correlative Study. Neurobiol Aging. 2000;21(1):39-47. PubMed PMID: 10794847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microglia, amyloid and dementia in alzheimer disease. A correlative study. AU - Arends,Y M, AU - Duyckaerts,C, AU - Rozemuller,J M, AU - Eikelenboom,P, AU - Hauw,J J, PY - 2000/5/5/pubmed PY - 2000/7/15/medline PY - 2000/5/5/entrez SP - 39 EP - 47 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 21 IS - 1 N2 - To elucidate the role of microglia in Alzheimer's disease, a clinicopathological study was performed involving 26 cases, the mental status of which had been studied pre mortem by the Blessed test score (BTS). We measured the volume density of CD 68 immunoreactive (IR) microglia, congophilic plaques and Abeta deposits, and the numerical density of neurofibrillary tangles (NFT) in a sample of Area 9 (middle frontal gyrus). Dementia was significantly correlated only with the volume density of Abeta deposits and the numerical density of NFT. The volume densities of microglia and congophilic plaques were strongly correlated. With the intellectual status used as a time scale, IR microglia and amyloid deposits appeared almost simultaneously at an early stage in the pathological cascade and decreased, whereas Abeta and NFT were still accumulating. The intellectual deficit seemed to be more significantly related to the latter two lesions than to the microglia-amyloid complex, that was visible at an earlier stage (around BTS = 15). SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/10794847/Microglia_amyloid_and_dementia_in_alzheimer_disease__A_correlative_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(00)00094-4 DB - PRIME DP - Unbound Medicine ER -