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Midlife blood pressure and dementia: the Honolulu-Asia aging study.

Abstract

We studied the association of mid-life blood pressure to late age dementia, specifically Alzheimer's disease and vascular dementia. Data are from the cohort of 3703 Japanese-American men who were followed in the Honolulu Heart Program (HHP;1965-1971), and subsequently re-examined in 1991 for dementia. We assessed the risk (odds ratio (95% CI)) for dementia associated with categories of systolic (SBP) and diastolic blood pressure (DBP), stratified by never/ever treatment with anti-hypertensive medications, and adjusting for age, education, apolipoprotein epsilon allele, smoking and alcohol intake. Among those never treated (57% sample), the risk for dementia was OR 95% CI 3.8 (1.6-8.7) for DBP of 90-94 mm Hg, and 4. 3 (1.7-10.8) for DBP of 95 mmHg and over compared to those with DBP of 80 to 89 mm Hg. Compared to those with SBP of 110 to 139 mm Hg, the risk for dementia was 4.8 (2.0-11.0) in those with SBP 160 mm Hg and higher. Blood pressure was not associated with the risk for dementia in treated men. These results were consistent for Alzheimer's disease and vascular dementia. This study suggests elevated levels of blood pressure in middle age can increase the risk for late age dementia in men never treated with anti-hypertensive medication.

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  • Authors+Show Affiliations

    ,

    Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Gateway Building 3C-309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA. LaunerL@exmur.nia.nih.gov

    , , , , ,

    Source

    Neurobiology of aging 21:1 pg 49-55

    MeSH

    Age Factors
    Aged
    Aging
    Alzheimer Disease
    Antihypertensive Agents
    Apolipoprotein E4
    Apolipoproteins E
    Asian Americans
    Asian Continental Ancestry Group
    Blood Pressure
    Cohort Studies
    Comorbidity
    Dementia, Vascular
    Diastole
    Hawaii
    Humans
    Hypertension
    Logistic Models
    Male
    Middle Aged
    Odds Ratio
    Risk Assessment
    Risk Factors
    Systole

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10794848

    Citation

    Launer, L J., et al. "Midlife Blood Pressure and Dementia: the Honolulu-Asia Aging Study." Neurobiology of Aging, vol. 21, no. 1, 2000, pp. 49-55.
    Launer LJ, Ross GW, Petrovitch H, et al. Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiol Aging. 2000;21(1):49-55.
    Launer, L. J., Ross, G. W., Petrovitch, H., Masaki, K., Foley, D., White, L. R., & Havlik, R. J. (2000). Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiology of Aging, 21(1), pp. 49-55.
    Launer LJ, et al. Midlife Blood Pressure and Dementia: the Honolulu-Asia Aging Study. Neurobiol Aging. 2000;21(1):49-55. PubMed PMID: 10794848.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Midlife blood pressure and dementia: the Honolulu-Asia aging study. AU - Launer,L J, AU - Ross,G W, AU - Petrovitch,H, AU - Masaki,K, AU - Foley,D, AU - White,L R, AU - Havlik,R J, PY - 2000/5/5/pubmed PY - 2000/7/15/medline PY - 2000/5/5/entrez SP - 49 EP - 55 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 21 IS - 1 N2 - We studied the association of mid-life blood pressure to late age dementia, specifically Alzheimer's disease and vascular dementia. Data are from the cohort of 3703 Japanese-American men who were followed in the Honolulu Heart Program (HHP;1965-1971), and subsequently re-examined in 1991 for dementia. We assessed the risk (odds ratio (95% CI)) for dementia associated with categories of systolic (SBP) and diastolic blood pressure (DBP), stratified by never/ever treatment with anti-hypertensive medications, and adjusting for age, education, apolipoprotein epsilon allele, smoking and alcohol intake. Among those never treated (57% sample), the risk for dementia was OR 95% CI 3.8 (1.6-8.7) for DBP of 90-94 mm Hg, and 4. 3 (1.7-10.8) for DBP of 95 mmHg and over compared to those with DBP of 80 to 89 mm Hg. Compared to those with SBP of 110 to 139 mm Hg, the risk for dementia was 4.8 (2.0-11.0) in those with SBP 160 mm Hg and higher. Blood pressure was not associated with the risk for dementia in treated men. These results were consistent for Alzheimer's disease and vascular dementia. This study suggests elevated levels of blood pressure in middle age can increase the risk for late age dementia in men never treated with anti-hypertensive medication. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/10794848/Midlife_blood_pressure_and_dementia:_the_Honolulu_Asia_aging_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(00)00096-8 DB - PRIME DP - Unbound Medicine ER -