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Screening for urinary tract infections in a gynaecological setting: validity and cost-effectiveness of reagent strips.
Br J Biomed Sci. 1999; 56(4):253-7.BJ

Abstract

This study aims to test the validity and cost-effectiveness of reagent-strip analysis compared with microbiological laboratory testing for mass screening of urine for urinary tract infections in a gynaecological setting. Over a six-month period, urine samples from a convenient group of 228 women presenting in a gynaecological ward of an NHS Trust hospital were tested using Ames 8SG reagent strips to detect leucocyte esterase and nitrite. Total bacterial counts were also carried out; urine culture was recorded as positive if there was > 10(5) organisms/mL. Validity of the dipstick tests was measured, using four criteria (sensitivity, specificity, positive predictive value [PPV] and negative predictive value [NPV]), against the results of laboratory analysis. The combined use of the leucocyte esterase and nitrite tests produced results as follows: sensitivity, 96.4%; specificity, 88.5%; PPV, 54%; and NPV, 99.4%. Cost-effectiveness for visible costs was calculated as 48.6% for the 12.3% rate of infection in this study. The use of reagent strips in a mass-screening programme in a gynaecological setting proved both valid and cost-effective.

Authors+Show Affiliations

Leicester Royal Infirmary NHS Trust, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10795368

Citation

Preston, A, et al. "Screening for Urinary Tract Infections in a Gynaecological Setting: Validity and Cost-effectiveness of Reagent Strips." British Journal of Biomedical Science, vol. 56, no. 4, 1999, pp. 253-7.
Preston A, O'Donnell T, Phillips CA. Screening for urinary tract infections in a gynaecological setting: validity and cost-effectiveness of reagent strips. Br J Biomed Sci. 1999;56(4):253-7.
Preston, A., O'Donnell, T., & Phillips, C. A. (1999). Screening for urinary tract infections in a gynaecological setting: validity and cost-effectiveness of reagent strips. British Journal of Biomedical Science, 56(4), 253-7.
Preston A, O'Donnell T, Phillips CA. Screening for Urinary Tract Infections in a Gynaecological Setting: Validity and Cost-effectiveness of Reagent Strips. Br J Biomed Sci. 1999;56(4):253-7. PubMed PMID: 10795368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening for urinary tract infections in a gynaecological setting: validity and cost-effectiveness of reagent strips. AU - Preston,A, AU - O'Donnell,T, AU - Phillips,C A, PY - 2000/5/5/pubmed PY - 2000/5/20/medline PY - 2000/5/5/entrez SP - 253 EP - 7 JF - British journal of biomedical science JO - Br J Biomed Sci VL - 56 IS - 4 N2 - This study aims to test the validity and cost-effectiveness of reagent-strip analysis compared with microbiological laboratory testing for mass screening of urine for urinary tract infections in a gynaecological setting. Over a six-month period, urine samples from a convenient group of 228 women presenting in a gynaecological ward of an NHS Trust hospital were tested using Ames 8SG reagent strips to detect leucocyte esterase and nitrite. Total bacterial counts were also carried out; urine culture was recorded as positive if there was > 10(5) organisms/mL. Validity of the dipstick tests was measured, using four criteria (sensitivity, specificity, positive predictive value [PPV] and negative predictive value [NPV]), against the results of laboratory analysis. The combined use of the leucocyte esterase and nitrite tests produced results as follows: sensitivity, 96.4%; specificity, 88.5%; PPV, 54%; and NPV, 99.4%. Cost-effectiveness for visible costs was calculated as 48.6% for the 12.3% rate of infection in this study. The use of reagent strips in a mass-screening programme in a gynaecological setting proved both valid and cost-effective. SN - 0967-4845 UR - https://www.unboundmedicine.com/medline/citation/10795368/Screening_for_urinary_tract_infections_in_a_gynaecological_setting:_validity_and_cost_effectiveness_of_reagent_strips_ L2 - https://medlineplus.gov/urinarytractinfections.html DB - PRIME DP - Unbound Medicine ER -