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Maternal antigen avoidance during lactation for preventing atopic eczema in infants.

Abstract

OBJECTIVES

To assess the effects of prescribing an antigen avoidance diet to lactating mothers of infants with atopic eczema on the severity of the eczema.

SEARCH STRATEGY

The register of clinical trials maintained and updated by the Cochrane Pregnancy and Childbirth Group.

SELECTION CRITERIA

All acceptably controlled comparisons of maternal antigen avoidance prescribed to lactating mothers of infants with atopic eczema, regardless of the degree of antigen avoidance (number of foods eliminated from the diet) or its duration.

DATA COLLECTION AND ANALYSIS

Data were extracted by the author from published reports, and supplemented by additional information from trialists contacted by the author.

MAIN RESULTS

One trial involving 17 women was included. Based on this single small trial, maternal antigen avoidance was associated with a nonsignificant reduction in eczema severity.

REVIEWER'S CONCLUSIONS

The unimpressive results of this single trial should be interpreted with caution both because of its small size (n=17) and because the trial compared exposure to cow milk and egg with exposure to soya milk (soya can itself be allergenic). Maternal reports of changes in the severity of their breast-fed infants' eczema following ingestion of certain foods should be pursued by performing multiple (preferably double-blinded) challenges and dechallenges with the suspected foods.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Faculty of Medicine, McGill University, 1020 Pine Avenue West, Montreal, Quebec, Canada, H3A 1A2. mikek@epid.lan.mcgill.ca

    Source

    MeSH

    Dermatitis, Atopic
    Dietary Proteins
    Female
    Humans
    Infant, Newborn
    Lactation

    Pub Type(s)

    Journal Article
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    10796148

    Citation

    Kramer, M S.. "Maternal Antigen Avoidance During Lactation for Preventing Atopic Eczema in Infants." The Cochrane Database of Systematic Reviews, 2000, p. CD000131.
    Kramer MS. Maternal antigen avoidance during lactation for preventing atopic eczema in infants. Cochrane Database Syst Rev. 2000.
    Kramer, M. S. (2000). Maternal antigen avoidance during lactation for preventing atopic eczema in infants. The Cochrane Database of Systematic Reviews, (2), p. CD000131.
    Kramer MS. Maternal Antigen Avoidance During Lactation for Preventing Atopic Eczema in Infants. Cochrane Database Syst Rev. 2000;(2)CD000131. PubMed PMID: 10796148.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Maternal antigen avoidance during lactation for preventing atopic eczema in infants. A1 - Kramer,M S, PY - 2000/5/5/pubmed PY - 2000/7/8/medline PY - 2000/5/5/entrez SP - CD000131 EP - CD000131 JF - The Cochrane database of systematic reviews JO - Cochrane Database Syst Rev IS - 2 N2 - OBJECTIVES: To assess the effects of prescribing an antigen avoidance diet to lactating mothers of infants with atopic eczema on the severity of the eczema. SEARCH STRATEGY: The register of clinical trials maintained and updated by the Cochrane Pregnancy and Childbirth Group. SELECTION CRITERIA: All acceptably controlled comparisons of maternal antigen avoidance prescribed to lactating mothers of infants with atopic eczema, regardless of the degree of antigen avoidance (number of foods eliminated from the diet) or its duration. DATA COLLECTION AND ANALYSIS: Data were extracted by the author from published reports, and supplemented by additional information from trialists contacted by the author. MAIN RESULTS: One trial involving 17 women was included. Based on this single small trial, maternal antigen avoidance was associated with a nonsignificant reduction in eczema severity. REVIEWER'S CONCLUSIONS: The unimpressive results of this single trial should be interpreted with caution both because of its small size (n=17) and because the trial compared exposure to cow milk and egg with exposure to soya milk (soya can itself be allergenic). Maternal reports of changes in the severity of their breast-fed infants' eczema following ingestion of certain foods should be pursued by performing multiple (preferably double-blinded) challenges and dechallenges with the suspected foods. SN - 1469-493X UR - https://www.unboundmedicine.com/medline/citation/10796148/Maternal_antigen_avoidance_during_lactation_for_preventing_atopic_eczema_in_infants_ L2 - https://doi.org/10.1002/14651858.CD000131 DB - PRIME DP - Unbound Medicine ER -