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Antioxidant vitamin and mineral supplements for age-related macular degeneration.

Abstract

BACKGROUND

It has been proposed that antioxidants may prevent cellular damage in the retina by reacting with free radicals produced in the process of light absorption.

OBJECTIVES

The objective of this review is to assess the effects of antioxidant vitamin and/or mineral supplementation on the progression of age-related macular degeneration.

SEARCH STRATEGY

The Cochrane Eyes and Vision Group specialised registered, the Cochrane Controlled Trials Register - Central, MEDLINE, the Science Citation Index, and the reference lists of relevant articles were searched. Investigators of included studies were contacted. The most recent searches were performed in December 1999.

SELECTION CRITERIA

All randomised trials comparing an antioxidant vitamin and/or mineral supplement (alone or in combination) to control in people with age-related macular degeneration were included.

DATA COLLECTION AND ANALYSIS

The reviewer extracted data and assessed trial quality. Due to the small number of trials identified, and variable methods of collecting and presenting outcome data, no statistical summary measure was calculated.

MAIN RESULTS

Four published, two unpublished and two ongoing trials were identified. Published trials to date have been small and results inconsistent. Adverse effects and quality of life for people with age-related macular degeneration have not been addressed.

REVIEWER'S CONCLUSIONS

The question as to whether people with age-related macular degeneration should take antioxidant vitamin or mineral supplements to prevent progression of the disease has not been answered by research to date. The results of ongoing trials are awaited.

Authors+Show Affiliations

'Glaxo' Department of Ophthalmology Epidemiology, Institute of Ophthalmology (UCL) and Moorfields Eye Hospital, City Road, London, UK, EC1V 2PD. jennifer.evans@ucl.ac.uk

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

10796708

Citation

Evans, J R.. "Antioxidant Vitamin and Mineral Supplements for Age-related Macular Degeneration." The Cochrane Database of Systematic Reviews, 2000, p. CD000254.
Evans JR. Antioxidant vitamin and mineral supplements for age-related macular degeneration. Cochrane Database Syst Rev. 2000.
Evans, J. R. (2000). Antioxidant vitamin and mineral supplements for age-related macular degeneration. The Cochrane Database of Systematic Reviews, (2), CD000254.
Evans JR. Antioxidant Vitamin and Mineral Supplements for Age-related Macular Degeneration. Cochrane Database Syst Rev. 2000;(2)CD000254. PubMed PMID: 10796708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant vitamin and mineral supplements for age-related macular degeneration. A1 - Evans,J R, PY - 2000/5/5/pubmed PY - 2000/7/8/medline PY - 2000/5/5/entrez SP - CD000254 EP - CD000254 JF - The Cochrane database of systematic reviews JO - Cochrane Database Syst Rev IS - 2 N2 - BACKGROUND: It has been proposed that antioxidants may prevent cellular damage in the retina by reacting with free radicals produced in the process of light absorption. OBJECTIVES: The objective of this review is to assess the effects of antioxidant vitamin and/or mineral supplementation on the progression of age-related macular degeneration. SEARCH STRATEGY: The Cochrane Eyes and Vision Group specialised registered, the Cochrane Controlled Trials Register - Central, MEDLINE, the Science Citation Index, and the reference lists of relevant articles were searched. Investigators of included studies were contacted. The most recent searches were performed in December 1999. SELECTION CRITERIA: All randomised trials comparing an antioxidant vitamin and/or mineral supplement (alone or in combination) to control in people with age-related macular degeneration were included. DATA COLLECTION AND ANALYSIS: The reviewer extracted data and assessed trial quality. Due to the small number of trials identified, and variable methods of collecting and presenting outcome data, no statistical summary measure was calculated. MAIN RESULTS: Four published, two unpublished and two ongoing trials were identified. Published trials to date have been small and results inconsistent. Adverse effects and quality of life for people with age-related macular degeneration have not been addressed. REVIEWER'S CONCLUSIONS: The question as to whether people with age-related macular degeneration should take antioxidant vitamin or mineral supplements to prevent progression of the disease has not been answered by research to date. The results of ongoing trials are awaited. SN - 1469-493X UR - https://www.unboundmedicine.com/medline/citation/10796708/Antioxidant_vitamin_and_mineral_supplements_for_age_related_macular_degeneration_ L2 - https://doi.org/10.1002/14651858.CD000254 DB - PRIME DP - Unbound Medicine ER -
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