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Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men.
Am J Clin Nutr. 2000 May; 71(5):1085-94.AJ

Abstract

BACKGROUND

Regular consumption of n-3 fatty acids of marine origin can improve serum lipids and reduce cardiovascular risk.

OBJECTIVE

This study aimed to determine whether eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids have differential effects on serum lipids and lipoproteins, glucose, and insulin in humans.

DESIGN

In a double-blind, placebo-controlled trial of parallel design, 59 overweight, nonsmoking, mildly hyperlipidemic men were randomly assigned to receive 4 g purified EPA, DHA, or olive oil (placebo) daily while continuing their usual diets for 6 wk.

RESULTS

Fifty-six men aged 48.8 +/- 1.1 y completed the study. Relative to those in the olive oil group, triacylglycerols fell by 0.45 +/- 0.15 mmol/L (approximately 20%; P = 0.003) in the DHA group and by 0.37 +/- 0.14 mmol/L (approximately 18%; P = 0.012) in the EPA group. Neither EPA nor DHA had any effect on total cholesterol. LDL, HDL, and HDL(2) cholesterol were not affected significantly by EPA, but HDL(3) cholesterol decreased significantly (6.7%; P = 0.032). Although HDL cholesterol was not significantly increased by DHA (3. 1%), HDL(2) cholesterol increased by approximately 29% (P = 0.004). DHA increased LDL cholesterol by 8% (P = 0.019). Adjusted LDL particle size increased by 0.25 +/- 0.08 nm (P = 0.002) with DHA but not with EPA. EPA supplementation increased plasma and platelet phospholipid EPA but reduced DHA. DHA supplementation increased DHA and EPA in plasma and platelet phospholipids. Both EPA and DHA increased fasting insulin significantly. EPA, but not DHA, tended to increase fasting glucose, but not significantly so.

CONCLUSIONS

EPA and DHA had differential effects on lipids, fatty acids, and glucose metabolism in overweight men with mild hyperlipidemia.

Authors+Show Affiliations

Department of Medicine, The University of Western Australia and The West Australian Heart Research Institute, Perth. tmori@cyllene.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10799369

Citation

Mori, T A., et al. "Purified Eicosapentaenoic and Docosahexaenoic Acids Have Differential Effects On Serum Lipids and Lipoproteins, LDL Particle Size, Glucose, and Insulin in Mildly Hyperlipidemic Men." The American Journal of Clinical Nutrition, vol. 71, no. 5, 2000, pp. 1085-94.
Mori TA, Burke V, Puddey IB, et al. Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am J Clin Nutr. 2000;71(5):1085-94.
Mori, T. A., Burke, V., Puddey, I. B., Watts, G. F., O'Neal, D. N., Best, J. D., & Beilin, L. J. (2000). Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. The American Journal of Clinical Nutrition, 71(5), 1085-94.
Mori TA, et al. Purified Eicosapentaenoic and Docosahexaenoic Acids Have Differential Effects On Serum Lipids and Lipoproteins, LDL Particle Size, Glucose, and Insulin in Mildly Hyperlipidemic Men. Am J Clin Nutr. 2000;71(5):1085-94. PubMed PMID: 10799369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. AU - Mori,T A, AU - Burke,V, AU - Puddey,I B, AU - Watts,G F, AU - O'Neal,D N, AU - Best,J D, AU - Beilin,L J, PY - 2000/5/9/pubmed PY - 2000/6/8/medline PY - 2000/5/9/entrez SP - 1085 EP - 94 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 71 IS - 5 N2 - BACKGROUND: Regular consumption of n-3 fatty acids of marine origin can improve serum lipids and reduce cardiovascular risk. OBJECTIVE: This study aimed to determine whether eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids have differential effects on serum lipids and lipoproteins, glucose, and insulin in humans. DESIGN: In a double-blind, placebo-controlled trial of parallel design, 59 overweight, nonsmoking, mildly hyperlipidemic men were randomly assigned to receive 4 g purified EPA, DHA, or olive oil (placebo) daily while continuing their usual diets for 6 wk. RESULTS: Fifty-six men aged 48.8 +/- 1.1 y completed the study. Relative to those in the olive oil group, triacylglycerols fell by 0.45 +/- 0.15 mmol/L (approximately 20%; P = 0.003) in the DHA group and by 0.37 +/- 0.14 mmol/L (approximately 18%; P = 0.012) in the EPA group. Neither EPA nor DHA had any effect on total cholesterol. LDL, HDL, and HDL(2) cholesterol were not affected significantly by EPA, but HDL(3) cholesterol decreased significantly (6.7%; P = 0.032). Although HDL cholesterol was not significantly increased by DHA (3. 1%), HDL(2) cholesterol increased by approximately 29% (P = 0.004). DHA increased LDL cholesterol by 8% (P = 0.019). Adjusted LDL particle size increased by 0.25 +/- 0.08 nm (P = 0.002) with DHA but not with EPA. EPA supplementation increased plasma and platelet phospholipid EPA but reduced DHA. DHA supplementation increased DHA and EPA in plasma and platelet phospholipids. Both EPA and DHA increased fasting insulin significantly. EPA, but not DHA, tended to increase fasting glucose, but not significantly so. CONCLUSIONS: EPA and DHA had differential effects on lipids, fatty acids, and glucose metabolism in overweight men with mild hyperlipidemia. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/10799369/Purified_eicosapentaenoic_and_docosahexaenoic_acids_have_differential_effects_on_serum_lipids_and_lipoproteins_LDL_particle_size_glucose_and_insulin_in_mildly_hyperlipidemic_men_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/71.5.1085 DB - PRIME DP - Unbound Medicine ER -