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Effectiveness and strategies of iron supplementation during pregnancy.

Abstract

Iron deficiency continues to be one of the most prevalent single-nutrient deficiencies in the world. Interventions are often designed to prevent the decrease in hemoglobin concentration and the decline in iron stores associated with pregnancy. Although this is believed to be desirable for both the health of the mother and the well-being of the growing fetus, some scientists disagree. Enrichment and fortification of food items, and dietary changes resulting from education interventions, have met with some success in developed countries, but not often in the developing world. A therapeutic approach to iron supplementation, rather than a public health-based approach, is used throughout much of the world but suffers from real, or perceived, problems of compliance. Large doses of iron are most often prescribed and are associated with side effects and with increased oxidative damage. Alternatively, delayed-release preparations and intermittent oral iron supplementation lead to better overall compliance and alleviate side effects. Daily iron intervention provides more protection against a decline in the storage iron pool in pregnant women than does an intermittent schedule, but the latter is generally associated with fewer side effects, better compliance, and possibly a reduction in risk of oxidative damage. An improved cost-benefit ratio associated with a lower-dose oral iron supplement may prove to be quite positive in the future. Currently, no single approach may be universally acceptable, although a moderate iron dosage protocol will likely provide the most benefit to those who require supplemental iron.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Nutrition Department, The Pennsylvania State University, University Park 16802, USA. its@psu.edu

    Source

    The American journal of clinical nutrition 71:5 Suppl 2000 05 pg 1288S-94S

    MeSH

    Anemia, Iron-Deficiency
    Dietary Supplements
    Female
    Humans
    Iron, Dietary
    Pregnancy
    Pregnancy Complications

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    10799404

    Citation

    Beard, J L.. "Effectiveness and Strategies of Iron Supplementation During Pregnancy." The American Journal of Clinical Nutrition, vol. 71, no. 5 Suppl, 2000, 1288S-94S.
    Beard JL. Effectiveness and strategies of iron supplementation during pregnancy. Am J Clin Nutr. 2000;71(5 Suppl):1288S-94S.
    Beard, J. L. (2000). Effectiveness and strategies of iron supplementation during pregnancy. The American Journal of Clinical Nutrition, 71(5 Suppl), 1288S-94S. doi:10.1093/ajcn/71.5.1288s.
    Beard JL. Effectiveness and Strategies of Iron Supplementation During Pregnancy. Am J Clin Nutr. 2000;71(5 Suppl):1288S-94S. PubMed PMID: 10799404.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effectiveness and strategies of iron supplementation during pregnancy. A1 - Beard,J L, PY - 2000/5/9/pubmed PY - 2000/6/8/medline PY - 2000/5/9/entrez SP - 1288S EP - 94S JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 71 IS - 5 Suppl N2 - Iron deficiency continues to be one of the most prevalent single-nutrient deficiencies in the world. Interventions are often designed to prevent the decrease in hemoglobin concentration and the decline in iron stores associated with pregnancy. Although this is believed to be desirable for both the health of the mother and the well-being of the growing fetus, some scientists disagree. Enrichment and fortification of food items, and dietary changes resulting from education interventions, have met with some success in developed countries, but not often in the developing world. A therapeutic approach to iron supplementation, rather than a public health-based approach, is used throughout much of the world but suffers from real, or perceived, problems of compliance. Large doses of iron are most often prescribed and are associated with side effects and with increased oxidative damage. Alternatively, delayed-release preparations and intermittent oral iron supplementation lead to better overall compliance and alleviate side effects. Daily iron intervention provides more protection against a decline in the storage iron pool in pregnant women than does an intermittent schedule, but the latter is generally associated with fewer side effects, better compliance, and possibly a reduction in risk of oxidative damage. An improved cost-benefit ratio associated with a lower-dose oral iron supplement may prove to be quite positive in the future. Currently, no single approach may be universally acceptable, although a moderate iron dosage protocol will likely provide the most benefit to those who require supplemental iron. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/10799404/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/71.5.1288s DB - PRIME DP - Unbound Medicine ER -