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[Dementia: risk and protective factors with special consideration of gender and hormone replacement therapy].
Z Arztl Fortbild Qualitatssich. 2000 Apr; 94(3):217-22.ZA

Abstract

This article focuses on the special role of women and their problems regarding the epidemiology and pathogenesis of dementia, especially Alzheimer's disease (AD). Recent epidemiological studies reveal higher rates of women affected by the two major dementing conditions, AD and vascular dementia (VaD). However, it is under debate whether a pure gender effect accounts for this, because gender differences e.g. in education, life expectancy, psychosocial development and health behaviour must be included in the analysis. Therefore it seems to be reasonable to have a look on gender related variances in other risk and protective factors of dementia. Recently, the menopause attracted the interest of dementia researchers, because retrospective studies revealed a favourable effect of hormone replacement therapy (HRT) on the incidence of AD by about 50%. However, in spite of well known "positive effects" of estrogens on the central nervous system, there is still not enough evidence for a recommendation of HRT for the prevention of AD and other dementias.

Authors+Show Affiliations

Psychiatrische Klinik und Poliklinik, Georg-August-Universität Göttingen. gstoppe@gwdg.de

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

10802897

Citation

Stoppe, G. "[Dementia: Risk and Protective Factors With Special Consideration of Gender and Hormone Replacement Therapy]." Zeitschrift Fur Arztliche Fortbildung Und Qualitatssicherung, vol. 94, no. 3, 2000, pp. 217-22.
Stoppe G. [Dementia: risk and protective factors with special consideration of gender and hormone replacement therapy]. Z Arztl Fortbild Qualitatssich. 2000;94(3):217-22.
Stoppe, G. (2000). [Dementia: risk and protective factors with special consideration of gender and hormone replacement therapy]. Zeitschrift Fur Arztliche Fortbildung Und Qualitatssicherung, 94(3), 217-22.
Stoppe G. [Dementia: Risk and Protective Factors With Special Consideration of Gender and Hormone Replacement Therapy]. Z Arztl Fortbild Qualitatssich. 2000;94(3):217-22. PubMed PMID: 10802897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Dementia: risk and protective factors with special consideration of gender and hormone replacement therapy]. A1 - Stoppe,G, PY - 2000/5/10/pubmed PY - 2000/6/3/medline PY - 2000/5/10/entrez SP - 217 EP - 22 JF - Zeitschrift fur arztliche Fortbildung und Qualitatssicherung JO - Z Arztl Fortbild Qualitatssich VL - 94 IS - 3 N2 - This article focuses on the special role of women and their problems regarding the epidemiology and pathogenesis of dementia, especially Alzheimer's disease (AD). Recent epidemiological studies reveal higher rates of women affected by the two major dementing conditions, AD and vascular dementia (VaD). However, it is under debate whether a pure gender effect accounts for this, because gender differences e.g. in education, life expectancy, psychosocial development and health behaviour must be included in the analysis. Therefore it seems to be reasonable to have a look on gender related variances in other risk and protective factors of dementia. Recently, the menopause attracted the interest of dementia researchers, because retrospective studies revealed a favourable effect of hormone replacement therapy (HRT) on the incidence of AD by about 50%. However, in spite of well known "positive effects" of estrogens on the central nervous system, there is still not enough evidence for a recommendation of HRT for the prevention of AD and other dementias. SN - 1431-7621 UR - https://www.unboundmedicine.com/medline/citation/10802897/[Dementia:_risk_and_protective_factors_with_special_consideration_of_gender_and_hormone_replacement_therapy]_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -