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[Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. II. Occurence and level of B. pertussis antigens in children with suspected whooping cough].
Med Dosw Mikrobiol. 1999; 51(3-4):269-80.MD

Abstract

The aim of this study was to determine and evaluate IgG, IgM and IgA levels to pertussis toxin (PT), filamentous hemagglutinin (FHA) and endotoxin (LPS) of B. pertussis in children with clinical symptoms of whooping cough. The serum samples obtained from 265 children (age range: 2 months-16 years) suspected of pertussis were examined by indirect haemagglutination (IH) and ELISA tests. Higher antibody level was most frequently observed in IgA class to PT, FHA and LPS in 45.3%, 35.1% and 66% of pertussis patients sera respectively. The least positive results were obtained in IgM class to PT and FHA (in 9.8% and 2.6% of children sera respectively) but in the case of LPS applied as the antigen in ELISA, higher IgM level was determined in 46.8% of pertussis patients sera. The four times increase of antibody level to LPS determined by IH was observed in 86.7% of children suspected of pertussis. Humoral response to B. pertussis infection is mainly connected with higher IgA level to PT, FHA, LPS and IgM to LPS in children with clinical symptoms of whooping cough.

Authors+Show Affiliations

Zakład Bakteriologii PZH w Warszawie.

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

10803256

Citation

Chodorowska, M. "[Humoral Reaction to Bordetella Pertussis Antigens: Pertussis Toxin, Filamentous Hemagglutinin and Lipopolysaccharide in Children With Clinical Symptoms of Whooping Cough. II. Occurence and Level of B. Pertussis Antigens in Children With Suspected Whooping Cough]." Medycyna Doswiadczalna I Mikrobiologia, vol. 51, no. 3-4, 1999, pp. 269-80.
Chodorowska M. [Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. II. Occurence and level of B. pertussis antigens in children with suspected whooping cough]. Med Dosw Mikrobiol. 1999;51(3-4):269-80.
Chodorowska, M. (1999). [Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. II. Occurence and level of B. pertussis antigens in children with suspected whooping cough]. Medycyna Doswiadczalna I Mikrobiologia, 51(3-4), 269-80.
Chodorowska M. [Humoral Reaction to Bordetella Pertussis Antigens: Pertussis Toxin, Filamentous Hemagglutinin and Lipopolysaccharide in Children With Clinical Symptoms of Whooping Cough. II. Occurence and Level of B. Pertussis Antigens in Children With Suspected Whooping Cough]. Med Dosw Mikrobiol. 1999;51(3-4):269-80. PubMed PMID: 10803256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Humoral reaction to Bordetella pertussis antigens: pertussis toxin, filamentous hemagglutinin and lipopolysaccharide in children with clinical symptoms of whooping cough. II. Occurence and level of B. pertussis antigens in children with suspected whooping cough]. A1 - Chodorowska,M, PY - 2000/5/10/pubmed PY - 2000/7/25/medline PY - 2000/5/10/entrez SP - 269 EP - 80 JF - Medycyna doswiadczalna i mikrobiologia JO - Med Dosw Mikrobiol VL - 51 IS - 3-4 N2 - The aim of this study was to determine and evaluate IgG, IgM and IgA levels to pertussis toxin (PT), filamentous hemagglutinin (FHA) and endotoxin (LPS) of B. pertussis in children with clinical symptoms of whooping cough. The serum samples obtained from 265 children (age range: 2 months-16 years) suspected of pertussis were examined by indirect haemagglutination (IH) and ELISA tests. Higher antibody level was most frequently observed in IgA class to PT, FHA and LPS in 45.3%, 35.1% and 66% of pertussis patients sera respectively. The least positive results were obtained in IgM class to PT and FHA (in 9.8% and 2.6% of children sera respectively) but in the case of LPS applied as the antigen in ELISA, higher IgM level was determined in 46.8% of pertussis patients sera. The four times increase of antibody level to LPS determined by IH was observed in 86.7% of children suspected of pertussis. Humoral response to B. pertussis infection is mainly connected with higher IgA level to PT, FHA, LPS and IgM to LPS in children with clinical symptoms of whooping cough. SN - 0025-8601 UR - https://www.unboundmedicine.com/medline/citation/10803256/[Humoral_reaction_to_Bordetella_pertussis_antigens:_pertussis_toxin_filamentous_hemagglutinin_and_lipopolysaccharide_in_children_with_clinical_symptoms_of_whooping_cough__II__Occurence_and_level_of_B__pertussis_antigens_in_children_with_suspected_whooping_cough]_ L2 - http://www.diseaseinfosearch.org/result/7491 DB - PRIME DP - Unbound Medicine ER -