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Effect of sulfur dioxide inhalation on erythrocyte antioxidant status and lipid peroxidation in experimental diabetes.
Diabetes Metab. 2000 Apr; 26(2):140-4.DM

Abstract

The effect of sulfur dioxide (SO(2)) on red cell antioxidant status and lipid peroxidation was examined in this research. Forty healthy male albino rats, aged three months, were divided into four equal groups: Control (C), SO(2) +C (CSO(2)), diabetic (D) and SO(2) +D (DSO(2)). Experimental diabetes mellitus was induced by i.v injection of alloxan with a dose of 50 mg/kg body weight. Ten ppm SO(2) was administered to the animals of SO(2) exposed groups in an exposure chamber for one hr/day x 7 days/wk x 6wks while other groups were exposed to filtered air in the same condition. SO(2) exposure, while markedly decreasing Cu, Zn-Superoxide dismutase (Cu, Zn-SOD) activity, significantly increased glutathione peroxidase (GSH-Px), catalase (CAT), glutathione (GSH) and glutathione-s-transferase (GST) activities and TBARS values in CSO(2) and DSO(2) groups compared with their respective control groups. From these results, it could be concluded that adaptative changes occurred in antioxidant systems that may counteract the free radical effect of SO(2) in the experimental groups.

Authors+Show Affiliations

Department of Physiology, Faculty of Medicine, Akdeniz University, Arapsuyu, 07070 Antalya, Turkey. aysel@hipokrat.med.akdeniz.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10804329

Citation

Agar, A, et al. "Effect of Sulfur Dioxide Inhalation On Erythrocyte Antioxidant Status and Lipid Peroxidation in Experimental Diabetes." Diabetes & Metabolism, vol. 26, no. 2, 2000, pp. 140-4.
Agar A, Küçükatay V, Yargicoglu P, et al. Effect of sulfur dioxide inhalation on erythrocyte antioxidant status and lipid peroxidation in experimental diabetes. Diabetes Metab. 2000;26(2):140-4.
Agar, A., Küçükatay, V., Yargicoglu, P., Bilmen, S., Gümüşlü, S., & Yücel, G. (2000). Effect of sulfur dioxide inhalation on erythrocyte antioxidant status and lipid peroxidation in experimental diabetes. Diabetes & Metabolism, 26(2), 140-4.
Agar A, et al. Effect of Sulfur Dioxide Inhalation On Erythrocyte Antioxidant Status and Lipid Peroxidation in Experimental Diabetes. Diabetes Metab. 2000;26(2):140-4. PubMed PMID: 10804329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of sulfur dioxide inhalation on erythrocyte antioxidant status and lipid peroxidation in experimental diabetes. AU - Agar,A, AU - Küçükatay,V, AU - Yargicoglu,P, AU - Bilmen,S, AU - Gümüşlü,S, AU - Yücel,G, PY - 2000/5/11/pubmed PY - 2000/7/6/medline PY - 2000/5/11/entrez SP - 140 EP - 4 JF - Diabetes & metabolism JO - Diabetes Metab VL - 26 IS - 2 N2 - The effect of sulfur dioxide (SO(2)) on red cell antioxidant status and lipid peroxidation was examined in this research. Forty healthy male albino rats, aged three months, were divided into four equal groups: Control (C), SO(2) +C (CSO(2)), diabetic (D) and SO(2) +D (DSO(2)). Experimental diabetes mellitus was induced by i.v injection of alloxan with a dose of 50 mg/kg body weight. Ten ppm SO(2) was administered to the animals of SO(2) exposed groups in an exposure chamber for one hr/day x 7 days/wk x 6wks while other groups were exposed to filtered air in the same condition. SO(2) exposure, while markedly decreasing Cu, Zn-Superoxide dismutase (Cu, Zn-SOD) activity, significantly increased glutathione peroxidase (GSH-Px), catalase (CAT), glutathione (GSH) and glutathione-s-transferase (GST) activities and TBARS values in CSO(2) and DSO(2) groups compared with their respective control groups. From these results, it could be concluded that adaptative changes occurred in antioxidant systems that may counteract the free radical effect of SO(2) in the experimental groups. SN - 1262-3636 UR - https://www.unboundmedicine.com/medline/citation/10804329/Effect_of_sulfur_dioxide_inhalation_on_erythrocyte_antioxidant_status_and_lipid_peroxidation_in_experimental_diabetes_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -