Tags

Type your tag names separated by a space and hit enter

[Role of hyperinsulinemia in pathogenesis of polycystic ovary syndrome and treatment by reduction of insulin secretion].
Zhonghua Fu Chan Ke Za Zhi. 1998 Dec; 33(12):731-4.ZF

Abstract

OBJECTIVE

To investigate the role of insulin in the polycystic ovary syndrome (PCOS) pathogenesis and application of Metformin in the treatment of PCOS.

METHODS

Serum androgen, luteinizing hormone (LH) and sex hormone-binding globulin(SHBG) concentration during fasting and serum 17 alpha-hydroxyprogesterone (17-OHP), LH level in response to gonadotropin-releasing hormone agonist (GnRH-a) stimulation were determined. Oral glucose-tolerance tests(OGTT) before and after oral administration of metoformin for 8-12 weeks were performed in 12 obese and 11 lean women with PCOS.

RESULTS

After oral administration of metformin for 8-12 weeks, fasting insulin concentration in obese group and area under curve (AUC) after OGTT in lean group decreased significantly. There were significant decrease in basal 17 alpha-hydroprogesterone, androstenedione, testosterone concentration, and increase in serum SHBG concentration in obese and lean groups. Basal LH and the response of serum 17-OHP, LH to GnRHa were not significantly changed.

CONCLUSIONS

Hyperinsulinemia may play an important role in hyperandrogenism GnRH-a of PCOS, and metformin may be used in the treatment of PCOS.

Authors+Show Affiliations

Naval General Nospital, Beijing.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

10806662

Citation

Wang, A, et al. "[Role of Hyperinsulinemia in Pathogenesis of Polycystic Ovary Syndrome and Treatment By Reduction of Insulin Secretion]." Zhonghua Fu Chan Ke Za Zhi, vol. 33, no. 12, 1998, pp. 731-4.
Wang A, Li M, Lu C. [Role of hyperinsulinemia in pathogenesis of polycystic ovary syndrome and treatment by reduction of insulin secretion]. Zhonghua Fu Chan Ke Za Zhi. 1998;33(12):731-4.
Wang, A., Li, M., & Lu, C. (1998). [Role of hyperinsulinemia in pathogenesis of polycystic ovary syndrome and treatment by reduction of insulin secretion]. Zhonghua Fu Chan Ke Za Zhi, 33(12), 731-4.
Wang A, Li M, Lu C. [Role of Hyperinsulinemia in Pathogenesis of Polycystic Ovary Syndrome and Treatment By Reduction of Insulin Secretion]. Zhonghua Fu Chan Ke Za Zhi. 1998;33(12):731-4. PubMed PMID: 10806662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Role of hyperinsulinemia in pathogenesis of polycystic ovary syndrome and treatment by reduction of insulin secretion]. AU - Wang,A, AU - Li,M, AU - Lu,C, PY - 2000/5/12/pubmed PY - 2000/6/17/medline PY - 2000/5/12/entrez SP - 731 EP - 4 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 33 IS - 12 N2 - OBJECTIVE: To investigate the role of insulin in the polycystic ovary syndrome (PCOS) pathogenesis and application of Metformin in the treatment of PCOS. METHODS: Serum androgen, luteinizing hormone (LH) and sex hormone-binding globulin(SHBG) concentration during fasting and serum 17 alpha-hydroxyprogesterone (17-OHP), LH level in response to gonadotropin-releasing hormone agonist (GnRH-a) stimulation were determined. Oral glucose-tolerance tests(OGTT) before and after oral administration of metoformin for 8-12 weeks were performed in 12 obese and 11 lean women with PCOS. RESULTS: After oral administration of metformin for 8-12 weeks, fasting insulin concentration in obese group and area under curve (AUC) after OGTT in lean group decreased significantly. There were significant decrease in basal 17 alpha-hydroprogesterone, androstenedione, testosterone concentration, and increase in serum SHBG concentration in obese and lean groups. Basal LH and the response of serum 17-OHP, LH to GnRHa were not significantly changed. CONCLUSIONS: Hyperinsulinemia may play an important role in hyperandrogenism GnRH-a of PCOS, and metformin may be used in the treatment of PCOS. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/10806662/[Role_of_hyperinsulinemia_in_pathogenesis_of_polycystic_ovary_syndrome_and_treatment_by_reduction_of_insulin_secretion]_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.