Tags

Type your tag names separated by a space and hit enter

[Study of interleukin-6 and tumor necrosis factor-alpha levels in maternal serum and amniotic fluid in patients with preterm premature rupture of membrane].
Zhonghua Fu Chan Ke Za Zhi. 1998 Jun; 33(6):328-30.ZF

Abstract

OBJECTIVE

To study the change and clinical significance of maternal serum and amniotic fluid interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) levels in patients with chorioamnionitis and premature rupture of membrane (PROM).

METHODS

Twenty normal term-pregnant women as control, and fourty-six women with PROM were enrolled for study. Maternal serum and amniotic fluid IL-6, TNF-alpha levels were measured by radioimmunoassay and enzyme-labeled immunosorbent assay (ELISA). Chorioamnionitis was diagnosed histologically.

RESULTS

The maternal serum IL-6 levels and amniotic fluid IL-6, TNF-alpha levels were higher in PROM group than that of control (P < 0.01). There was significant positive correlation between maternal IL-6, amniotic fluid IL-6, TNF-alpha levels and the duration from rupture of membrane, (the longer was time, the higher were the maternal IL-6 and the amniotic fluid IL-6. TNF-alpha). There were 12 cases with chorioamnionitis in patients with PROM and their maternal and amnotic fluid IL-6, TNF-alpha levels were higher than that of non-chorioamnionitis (P < 0.01-0.05).

CONCLUSION

IL-6 and TNF-alpha levels in maternal serum and amniotic fluid are valuable clinical indices for identification of chorioamnionitis in patients with PROM.

Authors+Show Affiliations

208th Hospital of PLA, Changchun.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

10806666

Citation

Wang, L, et al. "[Study of Interleukin-6 and Tumor Necrosis Factor-alpha Levels in Maternal Serum and Amniotic Fluid in Patients With Preterm Premature Rupture of Membrane]." Zhonghua Fu Chan Ke Za Zhi, vol. 33, no. 6, 1998, pp. 328-30.
Wang L, Zhang W, Wang Y. [Study of interleukin-6 and tumor necrosis factor-alpha levels in maternal serum and amniotic fluid in patients with preterm premature rupture of membrane]. Zhonghua Fu Chan Ke Za Zhi. 1998;33(6):328-30.
Wang, L., Zhang, W., & Wang, Y. (1998). [Study of interleukin-6 and tumor necrosis factor-alpha levels in maternal serum and amniotic fluid in patients with preterm premature rupture of membrane]. Zhonghua Fu Chan Ke Za Zhi, 33(6), 328-30.
Wang L, Zhang W, Wang Y. [Study of Interleukin-6 and Tumor Necrosis Factor-alpha Levels in Maternal Serum and Amniotic Fluid in Patients With Preterm Premature Rupture of Membrane]. Zhonghua Fu Chan Ke Za Zhi. 1998;33(6):328-30. PubMed PMID: 10806666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study of interleukin-6 and tumor necrosis factor-alpha levels in maternal serum and amniotic fluid in patients with preterm premature rupture of membrane]. AU - Wang,L, AU - Zhang,W, AU - Wang,Y, PY - 2000/5/12/pubmed PY - 2000/7/6/medline PY - 2000/5/12/entrez SP - 328 EP - 30 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 33 IS - 6 N2 - OBJECTIVE: To study the change and clinical significance of maternal serum and amniotic fluid interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) levels in patients with chorioamnionitis and premature rupture of membrane (PROM). METHODS: Twenty normal term-pregnant women as control, and fourty-six women with PROM were enrolled for study. Maternal serum and amniotic fluid IL-6, TNF-alpha levels were measured by radioimmunoassay and enzyme-labeled immunosorbent assay (ELISA). Chorioamnionitis was diagnosed histologically. RESULTS: The maternal serum IL-6 levels and amniotic fluid IL-6, TNF-alpha levels were higher in PROM group than that of control (P < 0.01). There was significant positive correlation between maternal IL-6, amniotic fluid IL-6, TNF-alpha levels and the duration from rupture of membrane, (the longer was time, the higher were the maternal IL-6 and the amniotic fluid IL-6. TNF-alpha). There were 12 cases with chorioamnionitis in patients with PROM and their maternal and amnotic fluid IL-6, TNF-alpha levels were higher than that of non-chorioamnionitis (P < 0.01-0.05). CONCLUSION: IL-6 and TNF-alpha levels in maternal serum and amniotic fluid are valuable clinical indices for identification of chorioamnionitis in patients with PROM. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/10806666/[Study_of_interleukin_6_and_tumor_necrosis_factor_alpha_levels_in_maternal_serum_and_amniotic_fluid_in_patients_with_preterm_premature_rupture_of_membrane]_ L2 - https://antibodies.cancer.gov/detail/CPTC-IL6-1 DB - PRIME DP - Unbound Medicine ER -