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The prevalence of pathogenic periodontal microflora in healthy young adult smokers.
J Periodontol. 2000 Apr; 71(4):562-7.JP

Abstract

BACKGROUND

Smoking is a major risk factor in periodontitis, although the mechanisms of its effects are not well understood. The overall goal of this clinical study was to determine if smoking enhances the colonization of the oral cavity by pathogenic bacteria in a periodontitis-free population. The prevalence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Campylobacter rectus, Eikenella corrodens, Bacteroides forsythus, and Treponema denticola was investigated in 25 smokers and 25 non-smokers by using DNA probes.

METHODS

The subjects were 21 to 35 years of age with a healthy periodontium or slight gingivitis and were systemically healthy. The test group included subjects who had a minimum of a 1.5 pack-year history of smoking, while the control subjects never smoked. Subgingival plaque samples were taken by paper point following the assessment of multiple clinical parameters.

RESULTS

This investigation showed: 1) no statistically significant differences were noted in any clinical parameter measured between the groups; 2) of the 8 subjects who were infected by at least 1 tested pathogen, seven were smokers (P= 0.02); 3) infected smokers had a 15.7+/-3.5 pack-year history and smoked a mean of 27+/-5 cigarettes/day versus 4.4+/-0.8 pack years and 15+/-1 cigarettes/day for the non-infected smokers (P = 0.0001 and P = 0.004); and 4) smokers were 18 times more likely to exhibit the presence of pathogens than non-smokers.

CONCLUSIONS

These data indicate that the prevalence of colonization of the sulcus by pathogenic bacterial species in periodontitis-free individuals is related to the quantity and duration of cigarette smoking.

Authors+Show Affiliations

Department of Periodontology, College of Dentistry, The University of Tennessee, Memphis 38163, USA. jshiloah@utmem.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10807119

Citation

Shiloah, J, et al. "The Prevalence of Pathogenic Periodontal Microflora in Healthy Young Adult Smokers." Journal of Periodontology, vol. 71, no. 4, 2000, pp. 562-7.
Shiloah J, Patters MR, Waring MB. The prevalence of pathogenic periodontal microflora in healthy young adult smokers. J Periodontol. 2000;71(4):562-7.
Shiloah, J., Patters, M. R., & Waring, M. B. (2000). The prevalence of pathogenic periodontal microflora in healthy young adult smokers. Journal of Periodontology, 71(4), 562-7.
Shiloah J, Patters MR, Waring MB. The Prevalence of Pathogenic Periodontal Microflora in Healthy Young Adult Smokers. J Periodontol. 2000;71(4):562-7. PubMed PMID: 10807119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of pathogenic periodontal microflora in healthy young adult smokers. AU - Shiloah,J, AU - Patters,M R, AU - Waring,M B, PY - 2000/5/12/pubmed PY - 2000/8/1/medline PY - 2000/5/12/entrez SP - 562 EP - 7 JF - Journal of periodontology JO - J Periodontol VL - 71 IS - 4 N2 - BACKGROUND: Smoking is a major risk factor in periodontitis, although the mechanisms of its effects are not well understood. The overall goal of this clinical study was to determine if smoking enhances the colonization of the oral cavity by pathogenic bacteria in a periodontitis-free population. The prevalence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Campylobacter rectus, Eikenella corrodens, Bacteroides forsythus, and Treponema denticola was investigated in 25 smokers and 25 non-smokers by using DNA probes. METHODS: The subjects were 21 to 35 years of age with a healthy periodontium or slight gingivitis and were systemically healthy. The test group included subjects who had a minimum of a 1.5 pack-year history of smoking, while the control subjects never smoked. Subgingival plaque samples were taken by paper point following the assessment of multiple clinical parameters. RESULTS: This investigation showed: 1) no statistically significant differences were noted in any clinical parameter measured between the groups; 2) of the 8 subjects who were infected by at least 1 tested pathogen, seven were smokers (P= 0.02); 3) infected smokers had a 15.7+/-3.5 pack-year history and smoked a mean of 27+/-5 cigarettes/day versus 4.4+/-0.8 pack years and 15+/-1 cigarettes/day for the non-infected smokers (P = 0.0001 and P = 0.004); and 4) smokers were 18 times more likely to exhibit the presence of pathogens than non-smokers. CONCLUSIONS: These data indicate that the prevalence of colonization of the sulcus by pathogenic bacterial species in periodontitis-free individuals is related to the quantity and duration of cigarette smoking. SN - 0022-3492 UR - https://www.unboundmedicine.com/medline/citation/10807119/The_prevalence_of_pathogenic_periodontal_microflora_in_healthy_young_adult_smokers_ L2 - https://doi.org/10.1902/jop.2000.71.4.562 DB - PRIME DP - Unbound Medicine ER -