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Allergenicity of mare's milk in children with cow's milk allergy.

Abstract

BACKGROUND

Cow's milk allergy is a common disease of infancy and early childhood. If the baby is not breast-fed, a substitute for cow's milk formula is necessary.

OBJECTIVE

The aim of this study was to investigate, in vitro and in vivo, the allergenicity of mare's milk in a population of selected children with severe IgE-mediated cow's milk allergy.

METHODS

Twenty-five children (17 male and 8 female) aged 19 to 72 months (median age 34 months) with IgE-mediated cow's milk allergy were selected for this study. All the children underwent skin prick tests with cow's milk and mare's milk and double-blind placebo-controlled oral food challenge (DBPCOFC) with fresh cow's milk, fresh mare's milk, and, as placebo, a soy formula (Isomil, Abbott, Campoverde, Italy). We performed immunoblotting of cow's and mare's milk developed with IgE from allergic children.

RESULTS

All the children showed strong positive skin test responses to cow's milk (4+); 2 children had positive skin test responses to mare's milk (2+). All children had positive DBPCOFCs to cow's milk; one child had a positive DBPCOFC to mare's milk. No children reacted to the placebo (Isomil). In the cow's milk, some proteins are able to strongly react with human IgE; when the sera are tested with mare's milk, the bands corresponding to the same proteins are recognized by a lower percentage of sera.

CONCLUSION

These data suggest that mare's milk can be regarded as a good substitute of cow's milk in most children with severe IgE-mediated cow's milk allergy. It would be prudent, however, to confirm its tolerability by a supervised titrated oral challenge test.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Allergy and Clinical Immunology, Department of Pediatrics, University La Sapienza, Rome, Italy.

    , , , , , , ,

    Source

    MeSH

    Administration, Oral
    Allergens
    Animals
    Child
    Child, Preschool
    Double-Blind Method
    Female
    Horses
    Humans
    Immunoblotting
    Immunoglobulin E
    Infant
    Male
    Milk
    Milk Hypersensitivity
    Skin Tests

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    10808187

    Citation

    Businco, L, et al. "Allergenicity of Mare's Milk in Children With Cow's Milk Allergy." The Journal of Allergy and Clinical Immunology, vol. 105, no. 5, 2000, pp. 1031-4.
    Businco L, Giampietro PG, Lucenti P, et al. Allergenicity of mare's milk in children with cow's milk allergy. J Allergy Clin Immunol. 2000;105(5):1031-4.
    Businco, L., Giampietro, P. G., Lucenti, P., Lucaroni, F., Pini, C., Di Felice, G., ... Orlandi, M. (2000). Allergenicity of mare's milk in children with cow's milk allergy. The Journal of Allergy and Clinical Immunology, 105(5), pp. 1031-4.
    Businco L, et al. Allergenicity of Mare's Milk in Children With Cow's Milk Allergy. J Allergy Clin Immunol. 2000;105(5):1031-4. PubMed PMID: 10808187.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Allergenicity of mare's milk in children with cow's milk allergy. AU - Businco,L, AU - Giampietro,P G, AU - Lucenti,P, AU - Lucaroni,F, AU - Pini,C, AU - Di Felice,G, AU - Iacovacci,P, AU - Curadi,C, AU - Orlandi,M, PY - 2000/5/16/pubmed PY - 2000/6/10/medline PY - 2000/5/16/entrez SP - 1031 EP - 4 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 105 IS - 5 N2 - BACKGROUND: Cow's milk allergy is a common disease of infancy and early childhood. If the baby is not breast-fed, a substitute for cow's milk formula is necessary. OBJECTIVE: The aim of this study was to investigate, in vitro and in vivo, the allergenicity of mare's milk in a population of selected children with severe IgE-mediated cow's milk allergy. METHODS: Twenty-five children (17 male and 8 female) aged 19 to 72 months (median age 34 months) with IgE-mediated cow's milk allergy were selected for this study. All the children underwent skin prick tests with cow's milk and mare's milk and double-blind placebo-controlled oral food challenge (DBPCOFC) with fresh cow's milk, fresh mare's milk, and, as placebo, a soy formula (Isomil, Abbott, Campoverde, Italy). We performed immunoblotting of cow's and mare's milk developed with IgE from allergic children. RESULTS: All the children showed strong positive skin test responses to cow's milk (4+); 2 children had positive skin test responses to mare's milk (2+). All children had positive DBPCOFCs to cow's milk; one child had a positive DBPCOFC to mare's milk. No children reacted to the placebo (Isomil). In the cow's milk, some proteins are able to strongly react with human IgE; when the sera are tested with mare's milk, the bands corresponding to the same proteins are recognized by a lower percentage of sera. CONCLUSION: These data suggest that mare's milk can be regarded as a good substitute of cow's milk in most children with severe IgE-mediated cow's milk allergy. It would be prudent, however, to confirm its tolerability by a supervised titrated oral challenge test. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/10808187/Allergenicity_of_mare's_milk_in_children_with_cow's_milk_allergy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674900953806 DB - PRIME DP - Unbound Medicine ER -