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Association of HLA-te22 antigen with anti-nuclear antibodies in Chinese patients with erosive oral lichen planus.
Proc Natl Sci Counc Repub China B. 2000 Apr; 24(2):63-9.PN

Abstract

The purpose of this study was to determine the frequencies of the presence of serum anti-nuclear antibodies (ANA) and smooth muscle antibodies (SMA) in 76 patients with oral lichen planus (OLP), in 77 patients with other oral mucosal diseases, and in 41 healthy control subjects. HLA phenotypes in some of the patients with OLP and recurrent aphthous ulcers (RAU) were determined to show whether there was an association of HLA antigens with the presence of autoantibodies. Indirect immunofluorescence techniques with mouse liver or stomach as the substrate were used to detect the serum ANA or SMA, respectively. The B lymphocytes isolated from peripheral blood were used for HLA typing by means of a standard microcytotoxicity assay. We found that the positive rate of serum ANA in patients with OLP (29%, p < 0.01), especially in patients with erosive OLP (34%, p < 0.001), was significantly higher than that in the normal control subjects (5%). The frequency of serum SMA in patients with OLP (20%, p < 0.01), in patients with RAU (17%, p < 0.01), or in patients with oral squamous cell carcinomas (41%, p < 0.001) was also significantly higher than that in normal control individuals (0%). In the erosive OLP group, the HLA-Te22 antigen occurred more frequently in patients with positive ANA (75%, p < 0.05) than in those with negative ANA (25%). We conclude that there is an association of HLA-Te22 antigen with ANA in Chinese patients with erosive OLP.

Authors+Show Affiliations

School of Dentistry, College of Medicine, National Taiwan University, Taipei, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10809082

Citation

Sun, A, et al. "Association of HLA-te22 Antigen With Anti-nuclear Antibodies in Chinese Patients With Erosive Oral Lichen Planus." Proceedings of the National Science Council, Republic of China. Part B, Life Sciences, vol. 24, no. 2, 2000, pp. 63-9.
Sun A, Wu YC, Wang JT, et al. Association of HLA-te22 antigen with anti-nuclear antibodies in Chinese patients with erosive oral lichen planus. Proc Natl Sci Counc Repub China B. 2000;24(2):63-9.
Sun, A., Wu, Y. C., Wang, J. T., Liu, B. Y., & Chiang, C. P. (2000). Association of HLA-te22 antigen with anti-nuclear antibodies in Chinese patients with erosive oral lichen planus. Proceedings of the National Science Council, Republic of China. Part B, Life Sciences, 24(2), 63-9.
Sun A, et al. Association of HLA-te22 Antigen With Anti-nuclear Antibodies in Chinese Patients With Erosive Oral Lichen Planus. Proc Natl Sci Counc Repub China B. 2000;24(2):63-9. PubMed PMID: 10809082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of HLA-te22 antigen with anti-nuclear antibodies in Chinese patients with erosive oral lichen planus. AU - Sun,A, AU - Wu,Y C, AU - Wang,J T, AU - Liu,B Y, AU - Chiang,C P, PY - 2000/5/16/pubmed PY - 2000/8/6/medline PY - 2000/5/16/entrez SP - 63 EP - 9 JF - Proceedings of the National Science Council, Republic of China. Part B, Life sciences JO - Proc Natl Sci Counc Repub China B VL - 24 IS - 2 N2 - The purpose of this study was to determine the frequencies of the presence of serum anti-nuclear antibodies (ANA) and smooth muscle antibodies (SMA) in 76 patients with oral lichen planus (OLP), in 77 patients with other oral mucosal diseases, and in 41 healthy control subjects. HLA phenotypes in some of the patients with OLP and recurrent aphthous ulcers (RAU) were determined to show whether there was an association of HLA antigens with the presence of autoantibodies. Indirect immunofluorescence techniques with mouse liver or stomach as the substrate were used to detect the serum ANA or SMA, respectively. The B lymphocytes isolated from peripheral blood were used for HLA typing by means of a standard microcytotoxicity assay. We found that the positive rate of serum ANA in patients with OLP (29%, p < 0.01), especially in patients with erosive OLP (34%, p < 0.001), was significantly higher than that in the normal control subjects (5%). The frequency of serum SMA in patients with OLP (20%, p < 0.01), in patients with RAU (17%, p < 0.01), or in patients with oral squamous cell carcinomas (41%, p < 0.001) was also significantly higher than that in normal control individuals (0%). In the erosive OLP group, the HLA-Te22 antigen occurred more frequently in patients with positive ANA (75%, p < 0.05) than in those with negative ANA (25%). We conclude that there is an association of HLA-Te22 antigen with ANA in Chinese patients with erosive OLP. SN - 0255-6596 UR - https://www.unboundmedicine.com/medline/citation/10809082/Association_of_HLA_te22_antigen_with_anti_nuclear_antibodies_in_Chinese_patients_with_erosive_oral_lichen_planus_ DB - PRIME DP - Unbound Medicine ER -