TY - JOUR T1 - Granulation of acetaminophen by a rotating fluidized-bed granulator. AU - Kawaguchi,T, AU - Sunada,H, AU - Yonezawa,Y, AU - Danjo,K, AU - Hasegawa,M, AU - Makino,T, AU - Sakamoto,H, AU - Fujita,K, AU - Tanino,T, AU - Kokubo,H, PY - 2000/5/16/pubmed PY - 2000/7/25/medline PY - 2000/5/16/entrez SP - 141 EP - 51 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 5 IS - 2 N2 - The purpose of this research was to evaluate the use of a rotating fluidized-bed granulator to produce acetaminophen granules with sufficient binding force between particles and good plasticity in tablets. Ethenzamide and ascorbic acid were used to compare the relationship between granulation and the sample wetness. It was revealed that a blade rotation rate of 300 rpm, inlet air flow rate of 42 m3/hr, and spraying pressure of 1.5 kg/cm3 produced tablets with the best properties. The granule and tablet properties of ethenzamide and ascorbic acid were compared to those of acetaminophen. These compounds showed different wetting behaviors with water and different compression behaviors. With an increase in medicament content, tablet hardness increased except for the ascorbic acid formulation. Capping and sticking were observed in acetaminophen and in ascorbic acid, respectively, and acetaminophen and ethenzamide showed prolonged disintegration time. SN - 1083-7450 UR - https://www.unboundmedicine.com/medline/citation/10810744/Granulation_of_acetaminophen_by_a_rotating_fluidized_bed_granulator_ L2 - https://www.tandfonline.com/doi/full/10.1081/pdt-100100529 DB - PRIME DP - Unbound Medicine ER -