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Ovarian mucinous cystadenocarcinoma as a cause of Zollinger-Ellison syndrome: report of a case and review of the literature.
Am J Gastroenterol. 2000 May; 95(5):1348-51.AJ

Abstract

Gastrin producing ovarian tumor is a rare cause of the Zollinger-Ellison syndrome. We report the case of an ovarian carcinoma showing increased plasma gastrin concentration. A 60-yr-old woman presented with epigastric pain and diarrhea. Physical examination showed a large mass in the lower abdomen. Computed tomography revealed a large multilocular ovarian cyst. Upper gastrointestinal endoscopy examination showed multiple ulcerations of the stomach and duodenum. The plasma gastrin level was 1500 pg/ml. No tumors were found in the pancreas and duodenum, and salpingo-oophorectomy was performed. Histologic examination revealed a mucinous tumor of borderline malignant potential. Immunoperoxidase studies for gastrin showed many gastrin-producing cells within the epithelium of the tumor. There have been 11 cases (including our patient) of gastrin-producing ovarian tumor reported in the literature. We review here the relevant literature. Although ovarian gastrinoma is extremely rare, it should be considered as a possible cause of the Zollinger-Ellison syndrome in women.

Authors+Show Affiliations

Department of Pathology, Hamamatsu Medical Center, Shizuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

10811352

Citation

Hirasawa, K, et al. "Ovarian Mucinous Cystadenocarcinoma as a Cause of Zollinger-Ellison Syndrome: Report of a Case and Review of the Literature." The American Journal of Gastroenterology, vol. 95, no. 5, 2000, pp. 1348-51.
Hirasawa K, Yamada M, Kitagawa M, et al. Ovarian mucinous cystadenocarcinoma as a cause of Zollinger-Ellison syndrome: report of a case and review of the literature. Am J Gastroenterol. 2000;95(5):1348-51.
Hirasawa, K., Yamada, M., Kitagawa, M., Takehira, Y., Tamakoshi, K., Nakamura, T., Kawamura, K., Takagi, M., Murohisa, B., Ozawa, T., Hanai, H., & Kaneko, E. (2000). Ovarian mucinous cystadenocarcinoma as a cause of Zollinger-Ellison syndrome: report of a case and review of the literature. The American Journal of Gastroenterology, 95(5), 1348-51.
Hirasawa K, et al. Ovarian Mucinous Cystadenocarcinoma as a Cause of Zollinger-Ellison Syndrome: Report of a Case and Review of the Literature. Am J Gastroenterol. 2000;95(5):1348-51. PubMed PMID: 10811352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ovarian mucinous cystadenocarcinoma as a cause of Zollinger-Ellison syndrome: report of a case and review of the literature. AU - Hirasawa,K, AU - Yamada,M, AU - Kitagawa,M, AU - Takehira,Y, AU - Tamakoshi,K, AU - Nakamura,T, AU - Kawamura,K, AU - Takagi,M, AU - Murohisa,B, AU - Ozawa,T, AU - Hanai,H, AU - Kaneko,E, PY - 2000/5/16/pubmed PY - 2000/6/3/medline PY - 2000/5/16/entrez SP - 1348 EP - 51 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 95 IS - 5 N2 - Gastrin producing ovarian tumor is a rare cause of the Zollinger-Ellison syndrome. We report the case of an ovarian carcinoma showing increased plasma gastrin concentration. A 60-yr-old woman presented with epigastric pain and diarrhea. Physical examination showed a large mass in the lower abdomen. Computed tomography revealed a large multilocular ovarian cyst. Upper gastrointestinal endoscopy examination showed multiple ulcerations of the stomach and duodenum. The plasma gastrin level was 1500 pg/ml. No tumors were found in the pancreas and duodenum, and salpingo-oophorectomy was performed. Histologic examination revealed a mucinous tumor of borderline malignant potential. Immunoperoxidase studies for gastrin showed many gastrin-producing cells within the epithelium of the tumor. There have been 11 cases (including our patient) of gastrin-producing ovarian tumor reported in the literature. We review here the relevant literature. Although ovarian gastrinoma is extremely rare, it should be considered as a possible cause of the Zollinger-Ellison syndrome in women. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10811352/Ovarian_mucinous_cystadenocarcinoma_as_a_cause_of_Zollinger_Ellison_syndrome:_report_of_a_case_and_review_of_the_literature_ L2 - https://Insights.ovid.com/pubmed?pmid=10811352 DB - PRIME DP - Unbound Medicine ER -