TY - JOUR T1 - Ovarian mucinous cystadenocarcinoma as a cause of Zollinger-Ellison syndrome: report of a case and review of the literature. AU - Hirasawa,K, AU - Yamada,M, AU - Kitagawa,M, AU - Takehira,Y, AU - Tamakoshi,K, AU - Nakamura,T, AU - Kawamura,K, AU - Takagi,M, AU - Murohisa,B, AU - Ozawa,T, AU - Hanai,H, AU - Kaneko,E, PY - 2000/5/16/pubmed PY - 2000/6/3/medline PY - 2000/5/16/entrez SP - 1348 EP - 51 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 95 IS - 5 N2 - Gastrin producing ovarian tumor is a rare cause of the Zollinger-Ellison syndrome. We report the case of an ovarian carcinoma showing increased plasma gastrin concentration. A 60-yr-old woman presented with epigastric pain and diarrhea. Physical examination showed a large mass in the lower abdomen. Computed tomography revealed a large multilocular ovarian cyst. Upper gastrointestinal endoscopy examination showed multiple ulcerations of the stomach and duodenum. The plasma gastrin level was 1500 pg/ml. No tumors were found in the pancreas and duodenum, and salpingo-oophorectomy was performed. Histologic examination revealed a mucinous tumor of borderline malignant potential. Immunoperoxidase studies for gastrin showed many gastrin-producing cells within the epithelium of the tumor. There have been 11 cases (including our patient) of gastrin-producing ovarian tumor reported in the literature. We review here the relevant literature. Although ovarian gastrinoma is extremely rare, it should be considered as a possible cause of the Zollinger-Ellison syndrome in women. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10811352/Ovarian_mucinous_cystadenocarcinoma_as_a_cause_of_Zollinger_Ellison_syndrome:_report_of_a_case_and_review_of_the_literature_ L2 - https://Insights.ovid.com/pubmed?pmid=10811352 DB - PRIME DP - Unbound Medicine ER -