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The effect of four-year hypolipidaemic treatment on the intimal thickness of the common carotid artery in patients with familiar hyperlipidaemia.
Int Angiol. 1999 Dec; 18(4):313-9.IA

Abstract

BACKGROUND

Cholesterol lowering in patients with above-average cholesterol levels has been shown to reduce the progression of atherosclerosis. We assess the effects of lipid lowering therapy on the progression of early, preintrusive carotid arterial atherosclerosis in high risk patients with familial hyperlipidaemia free of symptomatic cardiovascular disease.

METHODS

Fifty-two patients with familial hyperlipidaemia by were treated by diet and various hypolipidaemic drugs. Eighteen individuals were not taking hypolipidaemic drugs. In a prospective study by B-mode ultrasound we assessed the intima-media thickness of the distal common carotid arterial (CCA) far wall at baseline and after 4 years.

RESULTS

In a subgroup of 25 patients with familial hypercholesterolaemia there was a significant decrease in total and LDL cholesterol and reduction in the intima-media thickness (IMT) of the common carotid artery from 0.78+/-0.22 mm to 0.69+/-0.17 mm (p=0.004). In a subgroup of 27 patients with familial combined hyperlipidaemia significant decreases in total and LDL cholesterol and triglycerides were associated with a decrease in the IMT of common carotid. artery from 0.72+/-0.22 mm to 0.67+/-0.15 mm (p=0.044). In 18 individuals, who were not taking hypolipidaemic drugs, there were no significant changes in the levels of cholesterol and triglycerides and in the IMT of the common carotid artery (increase from 0.58+/-0.18 mm to 0.62+/-0.13 mm, p>0.05).

CONCLUSIONS

Lipid-lowering therapy in patients with familial hyperlipidaemia free of symptomatic cardiovascular disease reverses the progression of early, preintrusive atherosclerosis of the carotid artery. It is a beneficial sign indicating the possibility for atherosclerosis regression.

Authors+Show Affiliations

Department of Internal Medicine III, General Teaching Hospital and Charles University School of Medicine I, Prague, Czech Republic.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10811520

Citation

Spácil, J, et al. "The Effect of Four-year Hypolipidaemic Treatment On the Intimal Thickness of the Common Carotid Artery in Patients With Familiar Hyperlipidaemia." International Angiology : a Journal of the International Union of Angiology, vol. 18, no. 4, 1999, pp. 313-9.
Spácil J, Ceska R, Petrásek J, et al. The effect of four-year hypolipidaemic treatment on the intimal thickness of the common carotid artery in patients with familiar hyperlipidaemia. Int Angiol. 1999;18(4):313-9.
Spácil, J., Ceska, R., Petrásek, J., & Sobra, J. (1999). The effect of four-year hypolipidaemic treatment on the intimal thickness of the common carotid artery in patients with familiar hyperlipidaemia. International Angiology : a Journal of the International Union of Angiology, 18(4), 313-9.
Spácil J, et al. The Effect of Four-year Hypolipidaemic Treatment On the Intimal Thickness of the Common Carotid Artery in Patients With Familiar Hyperlipidaemia. Int Angiol. 1999;18(4):313-9. PubMed PMID: 10811520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of four-year hypolipidaemic treatment on the intimal thickness of the common carotid artery in patients with familiar hyperlipidaemia. AU - Spácil,J, AU - Ceska,R, AU - Petrásek,J, AU - Sobra,J, PY - 2000/5/16/pubmed PY - 2000/6/17/medline PY - 2000/5/16/entrez SP - 313 EP - 9 JF - International angiology : a journal of the International Union of Angiology JO - Int Angiol VL - 18 IS - 4 N2 - BACKGROUND: Cholesterol lowering in patients with above-average cholesterol levels has been shown to reduce the progression of atherosclerosis. We assess the effects of lipid lowering therapy on the progression of early, preintrusive carotid arterial atherosclerosis in high risk patients with familial hyperlipidaemia free of symptomatic cardiovascular disease. METHODS: Fifty-two patients with familial hyperlipidaemia by were treated by diet and various hypolipidaemic drugs. Eighteen individuals were not taking hypolipidaemic drugs. In a prospective study by B-mode ultrasound we assessed the intima-media thickness of the distal common carotid arterial (CCA) far wall at baseline and after 4 years. RESULTS: In a subgroup of 25 patients with familial hypercholesterolaemia there was a significant decrease in total and LDL cholesterol and reduction in the intima-media thickness (IMT) of the common carotid artery from 0.78+/-0.22 mm to 0.69+/-0.17 mm (p=0.004). In a subgroup of 27 patients with familial combined hyperlipidaemia significant decreases in total and LDL cholesterol and triglycerides were associated with a decrease in the IMT of common carotid. artery from 0.72+/-0.22 mm to 0.67+/-0.15 mm (p=0.044). In 18 individuals, who were not taking hypolipidaemic drugs, there were no significant changes in the levels of cholesterol and triglycerides and in the IMT of the common carotid artery (increase from 0.58+/-0.18 mm to 0.62+/-0.13 mm, p>0.05). CONCLUSIONS: Lipid-lowering therapy in patients with familial hyperlipidaemia free of symptomatic cardiovascular disease reverses the progression of early, preintrusive atherosclerosis of the carotid artery. It is a beneficial sign indicating the possibility for atherosclerosis regression. SN - 0392-9590 UR - https://www.unboundmedicine.com/medline/citation/10811520/The_effect_of_four_year_hypolipidaemic_treatment_on_the_intimal_thickness_of_the_common_carotid_artery_in_patients_with_familiar_hyperlipidaemia_ L2 - https://medlineplus.gov/cholesterolmedicines.html DB - PRIME DP - Unbound Medicine ER -