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Treatment of hirsutism with lowest-dose flutamide (62.5 mg/day).
Gynecol Endocrinol. 2000 Feb; 14(1):38-41.GE

Abstract

Flutamide has been used successfully in the treatment of hirsutism. However, flutamide may cause important side-effects. The aim of this study was to evaluate the clinical and hormonal effects of lowest-dose flutamide therapy. Sixty-one women with hirsutism aged 18-37 years (mean +/- SD 23.4 +/- 5.9 years) were included in the study. Patients received 62.5 mg flutamide once per day for a period of 12 months. A hirsutism score was determined according to a modified Ferriman-Gallwey scoring system. Before therapy, multiscreen blood chemistry, hormonal analysis and complete blood counts were performed. These parameters and hirsutism scores were repeated at 3, 6, 9 and 12 months during therapy. The modified Ferriman-Gallwey scores significantly decreased from 19.1 +/- 4.9 to 5.8 +/- 3.3 during the study (p < 0.0001). The percentage reductions in hirsutism scores (mean +/- SD) were 60.3 +/- 14.4% at 6 months, and 70.3 +/- 13.2% at 12 months. No significant side-effects or modifications in the menstrual cycles were observed. There were no significant differences in any of the hormone levels during therapy. In conclusion, the lowest dose of flutamide, 62.5 mg/day, is a well-tolerated therapeutic agent and can be used in the treatment of hirsutism.

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Authors+Show Affiliations

Müderris II
Department of Obstetrics and Gynecology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Bayram F
No affiliation info available
Güven M
No affiliation info available

MeSH

AdolescentAdultAndrogen AntagonistsFemaleFlutamideHirsutismHormonesHumansProspective StudiesTreatment Outcome

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

10813105

Citation

Müderris, I I., et al. "Treatment of Hirsutism With Lowest-dose Flutamide (62.5 Mg/day)." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 14, no. 1, 2000, pp. 38-41.
Müderris II, Bayram F, Güven M. Treatment of hirsutism with lowest-dose flutamide (62.5 mg/day). Gynecol Endocrinol. 2000;14(1):38-41.
Müderris, I. I., Bayram, F., & Güven, M. (2000). Treatment of hirsutism with lowest-dose flutamide (62.5 mg/day). Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 14(1), 38-41.
Müderris II, Bayram F, Güven M. Treatment of Hirsutism With Lowest-dose Flutamide (62.5 Mg/day). Gynecol Endocrinol. 2000;14(1):38-41. PubMed PMID: 10813105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of hirsutism with lowest-dose flutamide (62.5 mg/day). AU - Müderris,I I, AU - Bayram,F, AU - Güven,M, PY - 2000/5/17/pubmed PY - 2000/8/6/medline PY - 2000/5/17/entrez SP - 38 EP - 41 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 14 IS - 1 N2 - Flutamide has been used successfully in the treatment of hirsutism. However, flutamide may cause important side-effects. The aim of this study was to evaluate the clinical and hormonal effects of lowest-dose flutamide therapy. Sixty-one women with hirsutism aged 18-37 years (mean +/- SD 23.4 +/- 5.9 years) were included in the study. Patients received 62.5 mg flutamide once per day for a period of 12 months. A hirsutism score was determined according to a modified Ferriman-Gallwey scoring system. Before therapy, multiscreen blood chemistry, hormonal analysis and complete blood counts were performed. These parameters and hirsutism scores were repeated at 3, 6, 9 and 12 months during therapy. The modified Ferriman-Gallwey scores significantly decreased from 19.1 +/- 4.9 to 5.8 +/- 3.3 during the study (p < 0.0001). The percentage reductions in hirsutism scores (mean +/- SD) were 60.3 +/- 14.4% at 6 months, and 70.3 +/- 13.2% at 12 months. No significant side-effects or modifications in the menstrual cycles were observed. There were no significant differences in any of the hormone levels during therapy. In conclusion, the lowest dose of flutamide, 62.5 mg/day, is a well-tolerated therapeutic agent and can be used in the treatment of hirsutism. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/10813105/Treatment_of_hirsutism_with_lowest_dose_flutamide__62_5_mg/day__ L2 - https://www.tandfonline.com/doi/full/10.3109/09513590009167658 DB - PRIME DP - Unbound Medicine ER -