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Twin studies in schizophrenia with special emphasis on concordance figures.

Abstract

Twin studies in schizophrenia have been reviewed with special emphasis on concordance rates in population-based investigations. Sources of error have been discussed with particular focus on sampling. The pair-wise concordance rates in schizophrenia are 30-40% in MZ and 5-10% in DZ, with somewhat higher rates for proband concordance. The findings from twin studies support the diathesis stress model in schizophrenia, and it is argued that the polygenic model gives the best explanation for the empirical findings.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Psychiatry, University of Oslo, Oslo, Norway. einar.kringlen@psykiatri.uio.no

    Source

    MeSH

    Computational Biology
    Environment
    Humans
    Research Design
    Schizophrenia
    Twin Studies as Topic

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    10813799

    Citation

    Kringlen, E. "Twin Studies in Schizophrenia With Special Emphasis On Concordance Figures." American Journal of Medical Genetics, vol. 97, no. 1, 2000, pp. 4-11.
    Kringlen E. Twin studies in schizophrenia with special emphasis on concordance figures. Am J Med Genet. 2000;97(1):4-11.
    Kringlen, E. (2000). Twin studies in schizophrenia with special emphasis on concordance figures. American Journal of Medical Genetics, 97(1), pp. 4-11.
    Kringlen E. Twin Studies in Schizophrenia With Special Emphasis On Concordance Figures. Am J Med Genet. 2000;97(1):4-11. PubMed PMID: 10813799.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Twin studies in schizophrenia with special emphasis on concordance figures. A1 - Kringlen,E, PY - 2000/5/17/pubmed PY - 2003/4/4/medline PY - 2000/5/17/entrez SP - 4 EP - 11 JF - American journal of medical genetics JO - Am. J. Med. Genet. VL - 97 IS - 1 N2 - Twin studies in schizophrenia have been reviewed with special emphasis on concordance rates in population-based investigations. Sources of error have been discussed with particular focus on sampling. The pair-wise concordance rates in schizophrenia are 30-40% in MZ and 5-10% in DZ, with somewhat higher rates for proband concordance. The findings from twin studies support the diathesis stress model in schizophrenia, and it is argued that the polygenic model gives the best explanation for the empirical findings. SN - 0148-7299 UR - https://www.unboundmedicine.com/medline/citation/10813799/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0148-7299&date=2000&volume=97&issue=1&spage=4 DB - PRIME DP - Unbound Medicine ER -