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Linkage analysis of chromosome 2q in osteoarthritis.
Rheumatology (Oxford). 2000 Apr; 39(4):377-81.R

Abstract

BACKGROUND

In independent linkage studies chromosome 2q11-q24 and chromosome 2q23-35 have previously been implicated as regions potentially harbouring susceptibility loci for osteoarthritis (OA).

OBJECTIVE

To test chromosome 2q for linkage to idiopathic osteoarthritis.

METHODS

Using a cohort of 481 OA families that each contained at least one affected sibling pair with severe end-stage disease (ascertained by hip or knee joint replacement surgery), we conducted a linkage analysis of chromosome 2q using 16 polymorphic microsatellite markers at an average spacing of one marker every 8.5 cM.

RESULTS

Our results provide suggestive evidence for a locus at 2q31 with a maximum multipoint logarithm of the odds score (MLS) of 1.22 which increased to 2.19 in those families concordant for hip-only disease (n = 311). This suggestive linkage was greater in male-hip families (MLS = 1.57, n = 71) than in female-hip families (MLS = 0.71, n = 132).

CONCLUSIONS

Chromosome 2q is likely to contain at least one susceptibility locus for OA.

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Publisher Full Text

Authors+Show Affiliations

Loughlin J
University of Oxford, Institute of Molecular Medicine, Oxford, UK.
Mustafa Z
No affiliation info available
Smith A
No affiliation info available
Irven C
No affiliation info available
Carr AJ
No affiliation info available
Clipsham K
No affiliation info available
Chitnavis J
No affiliation info available
Bloomfield VA
No affiliation info available
McCartney M
No affiliation info available
Cox O
No affiliation info available
Sinsheimer JS
No affiliation info available
Sykes B
No affiliation info available
Chapman KE
No affiliation info available

MeSH

AdultAgedChromosomes, Human, Pair 2Cohort StudiesFemaleGenetic LinkageGenetic Predisposition to DiseaseHumansKnee JointMaleMiddle AgedOsteoarthritisPedigreeSeverity of Illness Index

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10817769

Citation

Loughlin, J, et al. "Linkage Analysis of Chromosome 2q in Osteoarthritis." Rheumatology (Oxford, England), vol. 39, no. 4, 2000, pp. 377-81.
Loughlin J, Mustafa Z, Smith A, et al. Linkage analysis of chromosome 2q in osteoarthritis. Rheumatology (Oxford). 2000;39(4):377-81.
Loughlin, J., Mustafa, Z., Smith, A., Irven, C., Carr, A. J., Clipsham, K., Chitnavis, J., Bloomfield, V. A., McCartney, M., Cox, O., Sinsheimer, J. S., Sykes, B., & Chapman, K. E. (2000). Linkage analysis of chromosome 2q in osteoarthritis. Rheumatology (Oxford, England), 39(4), 377-81.
Loughlin J, et al. Linkage Analysis of Chromosome 2q in Osteoarthritis. Rheumatology (Oxford). 2000;39(4):377-81. PubMed PMID: 10817769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Linkage analysis of chromosome 2q in osteoarthritis. AU - Loughlin,J, AU - Mustafa,Z, AU - Smith,A, AU - Irven,C, AU - Carr,A J, AU - Clipsham,K, AU - Chitnavis,J, AU - Bloomfield,V A, AU - McCartney,M, AU - Cox,O, AU - Sinsheimer,J S, AU - Sykes,B, AU - Chapman,K E, PY - 2000/5/19/pubmed PY - 2000/7/6/medline PY - 2000/5/19/entrez SP - 377 EP - 81 JF - Rheumatology (Oxford, England) JO - Rheumatology (Oxford) VL - 39 IS - 4 N2 - BACKGROUND: In independent linkage studies chromosome 2q11-q24 and chromosome 2q23-35 have previously been implicated as regions potentially harbouring susceptibility loci for osteoarthritis (OA). OBJECTIVE: To test chromosome 2q for linkage to idiopathic osteoarthritis. METHODS: Using a cohort of 481 OA families that each contained at least one affected sibling pair with severe end-stage disease (ascertained by hip or knee joint replacement surgery), we conducted a linkage analysis of chromosome 2q using 16 polymorphic microsatellite markers at an average spacing of one marker every 8.5 cM. RESULTS: Our results provide suggestive evidence for a locus at 2q31 with a maximum multipoint logarithm of the odds score (MLS) of 1.22 which increased to 2.19 in those families concordant for hip-only disease (n = 311). This suggestive linkage was greater in male-hip families (MLS = 1.57, n = 71) than in female-hip families (MLS = 0.71, n = 132). CONCLUSIONS: Chromosome 2q is likely to contain at least one susceptibility locus for OA. SN - 1462-0324 UR - https://www.unboundmedicine.com/medline/citation/10817769/Linkage_analysis_of_chromosome_2q_in_osteoarthritis_ L2 - https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/39.4.377 DB - PRIME DP - Unbound Medicine ER -