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Osteogenic induction in hereditary disorders of heterotopic ossification.

Abstract

The formation of heterotopic bone within soft connective tissue is a common feature of at least three distinct genetic disorders of osteogenesis in humans: fibrodysplasia ossificans progressiva; progressive osseous heteroplasia; and Albright hereditary osteodystrophy. The pathobiologic characteristics of osteogenic induction, the histopathologic features of osteogenesis, the anatomic distribution of heterotopic lesions, and the developmental patterns of disease progression differ among all three conditions. The molecular and cellular basis of redirecting a mature connective tissue phenotype to form bone is a remarkable biological phenomenon with enormous implications for the control of bone regeneration, fracture healing, and disorders of osteogenesis.

Authors+Show Affiliations

Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

10818990

Citation

Shore, E M., et al. "Osteogenic Induction in Hereditary Disorders of Heterotopic Ossification." Clinical Orthopaedics and Related Research, 2000, pp. 303-16.
Shore EM, Glaser DL, Gannon FH. Osteogenic induction in hereditary disorders of heterotopic ossification. Clin Orthop Relat Res. 2000.
Shore, E. M., Glaser, D. L., & Gannon, F. H. (2000). Osteogenic induction in hereditary disorders of heterotopic ossification. Clinical Orthopaedics and Related Research, (374), 303-16.
Shore EM, Glaser DL, Gannon FH. Osteogenic Induction in Hereditary Disorders of Heterotopic Ossification. Clin Orthop Relat Res. 2000;(374)303-16. PubMed PMID: 10818990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteogenic induction in hereditary disorders of heterotopic ossification. AU - Shore,E M, AU - Glaser,D L, AU - Gannon,F H, PY - 2000/5/20/pubmed PY - 2000/6/10/medline PY - 2000/5/20/entrez SP - 303 EP - 16 JF - Clinical orthopaedics and related research JO - Clin. Orthop. Relat. Res. IS - 374 N2 - The formation of heterotopic bone within soft connective tissue is a common feature of at least three distinct genetic disorders of osteogenesis in humans: fibrodysplasia ossificans progressiva; progressive osseous heteroplasia; and Albright hereditary osteodystrophy. The pathobiologic characteristics of osteogenic induction, the histopathologic features of osteogenesis, the anatomic distribution of heterotopic lesions, and the developmental patterns of disease progression differ among all three conditions. The molecular and cellular basis of redirecting a mature connective tissue phenotype to form bone is a remarkable biological phenomenon with enormous implications for the control of bone regeneration, fracture healing, and disorders of osteogenesis. SN - 0009-921X UR - https://www.unboundmedicine.com/medline/citation/10818990/Osteogenic_induction_in_hereditary_disorders_of_heterotopic_ossification_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10818990.ui DB - PRIME DP - Unbound Medicine ER -