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Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphé nucleus slices.
Synapse. 2000 Jun 15; 36(4):275-85.S

Abstract

We examined the effects of pressure ejected 3, 4-methylenedioxymethamphetamine (MDMA) from a micropipette on direct chemically stimulated release, and on electrically stimulated serotonin (5-HT) or dopamine (DA) release in the caudate putamen (CPu), nucleus accumbens (NAc), substantia nigra pars reticulata (SNr), and the dorsal raphé nucleus (DRN) brain slices of rat, using fast cyclic voltammetry (FCV). MDMA is electroactive, oxidising at +1100 mV. When the anodic input waveform was reduced from +1.4 to +1.0 volt, MDMA was not electroactive. Using this waveform, pressure ejection of MDMA did not release 5-HT or DA in brain slices prepared from any of the nuclei studied. MDMA significantly potentiated electrically stimulated 5-HT release in the SNr and DA release in CPu. In the DRN or in the NAc, MDMA was without effect on peak electrically stimulated 5-HT or DA release. The rates of neurotransmitter uptake, expressed as t(1/2), were in all cases significantly decreased after MDMA. The results indicate that MDMA, unlike (+)amphetamine, is not as a releaser of DA or 5-HT, it is a potent inhibitor of both DA and 5-HT uptake.

Authors+Show Affiliations

Department of Pharmacology, Queen Mary & Westfield College, University of London, UK. m.iravani@kcl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10819905

Citation

Iravani, M M., et al. "Direct Effects of 3,4-methylenedioxymethamphetamine (MDMA) On Serotonin or Dopamine Release and Uptake in the Caudate Putamen, Nucleus Accumbens, Substantia Nigra Pars Reticulata, and the Dorsal Raphé Nucleus Slices." Synapse (New York, N.Y.), vol. 36, no. 4, 2000, pp. 275-85.
Iravani MM, Asari D, Patel J, et al. Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphé nucleus slices. Synapse. 2000;36(4):275-85.
Iravani, M. M., Asari, D., Patel, J., Wieczorek, W. J., & Kruk, Z. L. (2000). Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphé nucleus slices. Synapse (New York, N.Y.), 36(4), 275-85.
Iravani MM, et al. Direct Effects of 3,4-methylenedioxymethamphetamine (MDMA) On Serotonin or Dopamine Release and Uptake in the Caudate Putamen, Nucleus Accumbens, Substantia Nigra Pars Reticulata, and the Dorsal Raphé Nucleus Slices. Synapse. 2000 Jun 15;36(4):275-85. PubMed PMID: 10819905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphé nucleus slices. AU - Iravani,M M, AU - Asari,D, AU - Patel,J, AU - Wieczorek,W J, AU - Kruk,Z L, PY - 2000/5/20/pubmed PY - 2000/6/10/medline PY - 2000/5/20/entrez SP - 275 EP - 85 JF - Synapse (New York, N.Y.) JO - Synapse VL - 36 IS - 4 N2 - We examined the effects of pressure ejected 3, 4-methylenedioxymethamphetamine (MDMA) from a micropipette on direct chemically stimulated release, and on electrically stimulated serotonin (5-HT) or dopamine (DA) release in the caudate putamen (CPu), nucleus accumbens (NAc), substantia nigra pars reticulata (SNr), and the dorsal raphé nucleus (DRN) brain slices of rat, using fast cyclic voltammetry (FCV). MDMA is electroactive, oxidising at +1100 mV. When the anodic input waveform was reduced from +1.4 to +1.0 volt, MDMA was not electroactive. Using this waveform, pressure ejection of MDMA did not release 5-HT or DA in brain slices prepared from any of the nuclei studied. MDMA significantly potentiated electrically stimulated 5-HT release in the SNr and DA release in CPu. In the DRN or in the NAc, MDMA was without effect on peak electrically stimulated 5-HT or DA release. The rates of neurotransmitter uptake, expressed as t(1/2), were in all cases significantly decreased after MDMA. The results indicate that MDMA, unlike (+)amphetamine, is not as a releaser of DA or 5-HT, it is a potent inhibitor of both DA and 5-HT uptake. SN - 0887-4476 UR - https://www.unboundmedicine.com/medline/citation/10819905/Direct_effects_of_34_methylenedioxymethamphetamine__MDMA__on_serotonin_or_dopamine_release_and_uptake_in_the_caudate_putamen_nucleus_accumbens_substantia_nigra_pars_reticulata_and_the_dorsal_raphé_nucleus_slices_ L2 - https://doi.org/10.1002/(SICI)1098-2396(20000615)36:4<275::AID-SYN4>3.0.CO;2-# DB - PRIME DP - Unbound Medicine ER -