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The incidence of lymphoma in first-degree relatives of patients with Hodgkin disease and non-Hodgkin lymphoma: results and limitations of a registry-linked study.
Cancer 2000; 88(10):2357-66C

Abstract

BACKGROUND

The precise incidence of familial Hodgkin disease (HD) and non-Hodgkin lymphoma (NHL) in first-degree relatives is unknown. Through record linkage using two population-based sources, the authors estimated the risk of HD and NHL in family members of lymphoma probands.

METHODS

The authors identified 8,037 first-degree relatives of 2,606 lymphoma cases (28.5% HD, 71.5% NHL) treated between 1970 and 1993 in 3 hospitals in Israel via the family file of the Population Registry. The authors linked this file with the Israel Cancer Registry, then calculated the standardized incidence ratio (SIR) by dividing the observed number of cases with the expected, adjusting for age, gender, calendar year, and continent of origin.

RESULTS

The family file yielded incomplete ascertainment of relatives (for 771 probands, no relatives were identified). Twenty cases of lymphoma--6 HD and 14 NHL--were identified among relatives of lymphoma patients. The SIR for HD was 1.15 (95% confidence interval [CI]: 0.42-2.51) and for NHL 1.71 (95% CI: 0.93-2.87), considering the entire population of first-degree relatives. SIRs among siblings of lymphoma probands were 3.12 (95% CI: 1.01-7.29) for HD, 2.16 (95% CI: 0.45-6.31) for NHL, and 2.68 (95% CI: 1.15-5.27) for all lymphomas. There were 4 HD/HD, 1 NHL/NHL, and 3 NHL/HD sibling pairs. For HD/HD and NHL/NHL sibling pairs, the interval between lymphoma occurrence in proband and sibling was 1-4 years, whereas for HD/NHL pairs this ranged from 16 to 21 years.

CONCLUSIONS

The risk of lymphoma among siblings of lymphoma probands was over 2.5-fold that of the general population and lower among other family members. The temporal proximity of HD/HD and NHL/NHL sibling pairs argues for environmental as well as genetic etiology. This method was hampered by incomplete data.

Authors+Show Affiliations

Department of Social Medicine, Hadassah Medical Center, Jerusalem, Israel. ora@vms.huji.ac.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

10820359

Citation

Paltiel, O, et al. "The Incidence of Lymphoma in First-degree Relatives of Patients With Hodgkin Disease and non-Hodgkin Lymphoma: Results and Limitations of a Registry-linked Study." Cancer, vol. 88, no. 10, 2000, pp. 2357-66.
Paltiel O, Schmit T, Adler B, et al. The incidence of lymphoma in first-degree relatives of patients with Hodgkin disease and non-Hodgkin lymphoma: results and limitations of a registry-linked study. Cancer. 2000;88(10):2357-66.
Paltiel, O., Schmit, T., Adler, B., Rachmilevitz, E. A., Polliack, A., Cohen, A., ... Ben Yehuda, D. (2000). The incidence of lymphoma in first-degree relatives of patients with Hodgkin disease and non-Hodgkin lymphoma: results and limitations of a registry-linked study. Cancer, 88(10), pp. 2357-66.
Paltiel O, et al. The Incidence of Lymphoma in First-degree Relatives of Patients With Hodgkin Disease and non-Hodgkin Lymphoma: Results and Limitations of a Registry-linked Study. Cancer. 2000 May 15;88(10):2357-66. PubMed PMID: 10820359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The incidence of lymphoma in first-degree relatives of patients with Hodgkin disease and non-Hodgkin lymphoma: results and limitations of a registry-linked study. AU - Paltiel,O, AU - Schmit,T, AU - Adler,B, AU - Rachmilevitz,E A, AU - Polliack,A, AU - Cohen,A, AU - Haim,N, AU - Shachar,M B, AU - Epelbaum,R, AU - Barchana,M, AU - Cohen,R, AU - Ben Yehuda,D, PY - 2000/5/23/pubmed PY - 2000/6/17/medline PY - 2000/5/23/entrez SP - 2357 EP - 66 JF - Cancer JO - Cancer VL - 88 IS - 10 N2 - BACKGROUND: The precise incidence of familial Hodgkin disease (HD) and non-Hodgkin lymphoma (NHL) in first-degree relatives is unknown. Through record linkage using two population-based sources, the authors estimated the risk of HD and NHL in family members of lymphoma probands. METHODS: The authors identified 8,037 first-degree relatives of 2,606 lymphoma cases (28.5% HD, 71.5% NHL) treated between 1970 and 1993 in 3 hospitals in Israel via the family file of the Population Registry. The authors linked this file with the Israel Cancer Registry, then calculated the standardized incidence ratio (SIR) by dividing the observed number of cases with the expected, adjusting for age, gender, calendar year, and continent of origin. RESULTS: The family file yielded incomplete ascertainment of relatives (for 771 probands, no relatives were identified). Twenty cases of lymphoma--6 HD and 14 NHL--were identified among relatives of lymphoma patients. The SIR for HD was 1.15 (95% confidence interval [CI]: 0.42-2.51) and for NHL 1.71 (95% CI: 0.93-2.87), considering the entire population of first-degree relatives. SIRs among siblings of lymphoma probands were 3.12 (95% CI: 1.01-7.29) for HD, 2.16 (95% CI: 0.45-6.31) for NHL, and 2.68 (95% CI: 1.15-5.27) for all lymphomas. There were 4 HD/HD, 1 NHL/NHL, and 3 NHL/HD sibling pairs. For HD/HD and NHL/NHL sibling pairs, the interval between lymphoma occurrence in proband and sibling was 1-4 years, whereas for HD/NHL pairs this ranged from 16 to 21 years. CONCLUSIONS: The risk of lymphoma among siblings of lymphoma probands was over 2.5-fold that of the general population and lower among other family members. The temporal proximity of HD/HD and NHL/NHL sibling pairs argues for environmental as well as genetic etiology. This method was hampered by incomplete data. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/10820359/The_incidence_of_lymphoma_in_first_degree_relatives_of_patients_with_Hodgkin_disease_and_non_Hodgkin_lymphoma:_results_and_limitations_of_a_registry_linked_study_ L2 - http://www.diseaseinfosearch.org/result/3444 DB - PRIME DP - Unbound Medicine ER -