Tags

Type your tag names separated by a space and hit enter

Changes in cytokine (IL-8, IL-6 and TNF-alpha) levels in the amniotic fluid and maternal serum in patients with premature rupture of the membranes.
Zhonghua Yi Xue Za Zhi (Taipei). 2000 Apr; 63(4):311-5.ZY

Abstract

PURPOSE

To study the changes in interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) levels in patients with premature rupture of the membranes (PROM).

METHODS

A total of 46 normal term pregnant women served as controls and 46 women with PROM were enrolled for study. Maternal serum and amniotic fluid IL-6, IL-8 and TNF-alpha levels were determined by enzyme-linked immunosorbent assay and a sensitive radioimmunoassay, respectively.

RESULTS

The maternal serum IL-6 and IL-8 levels and amniotic fluid IL-6, IL-8 and TNF-alpha levels were higher than those of controls, and the differences were significant between the two groups (p < 0.05). Although the levels of TNF-alpha in maternal serum were higher than that of controls, the difference was not significant. There were significant relationships between the levels of IL-6, IL-8 and TNF-alpha and the duration of PROM. The longer the duration of PROM, the higher the levels of maternal serum and amniotic fluid IL-6, IL-8 and TNF-alpha were. There were 12 cases of clinical chorioamnionitis, and the levels of IL-6, IL-8 and TNF-alpha in the maternal and amniotic fluid were higher than that of those without chorioamnionitis (p < 0.05).

CONCLUSION

Determining cytokines (IL-6, IL-8 and TNF-alpha) is a valuable clinical method for identifying chorioamnionitis in patients with PROM.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Second Teaching Hospital, Bethune University of Medical Sciences, Changchun, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10820910

Citation

Zhang, W, et al. "Changes in Cytokine (IL-8, IL-6 and TNF-alpha) Levels in the Amniotic Fluid and Maternal Serum in Patients With Premature Rupture of the Membranes." Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed, vol. 63, no. 4, 2000, pp. 311-5.
Zhang W, Wang L, Zhao Y, et al. Changes in cytokine (IL-8, IL-6 and TNF-alpha) levels in the amniotic fluid and maternal serum in patients with premature rupture of the membranes. Zhonghua Yi Xue Za Zhi (Taipei). 2000;63(4):311-5.
Zhang, W., Wang, L., Zhao, Y., & Kang, J. (2000). Changes in cytokine (IL-8, IL-6 and TNF-alpha) levels in the amniotic fluid and maternal serum in patients with premature rupture of the membranes. Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed, 63(4), 311-5.
Zhang W, et al. Changes in Cytokine (IL-8, IL-6 and TNF-alpha) Levels in the Amniotic Fluid and Maternal Serum in Patients With Premature Rupture of the Membranes. Zhonghua Yi Xue Za Zhi (Taipei). 2000;63(4):311-5. PubMed PMID: 10820910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in cytokine (IL-8, IL-6 and TNF-alpha) levels in the amniotic fluid and maternal serum in patients with premature rupture of the membranes. AU - Zhang,W, AU - Wang,L, AU - Zhao,Y, AU - Kang,J, PY - 2000/5/23/pubmed PY - 2000/6/3/medline PY - 2000/5/23/entrez SP - 311 EP - 5 JF - Zhonghua yi xue za zhi = Chinese medical journal; Free China ed JO - Zhonghua Yi Xue Za Zhi (Taipei) VL - 63 IS - 4 N2 - PURPOSE: To study the changes in interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) levels in patients with premature rupture of the membranes (PROM). METHODS: A total of 46 normal term pregnant women served as controls and 46 women with PROM were enrolled for study. Maternal serum and amniotic fluid IL-6, IL-8 and TNF-alpha levels were determined by enzyme-linked immunosorbent assay and a sensitive radioimmunoassay, respectively. RESULTS: The maternal serum IL-6 and IL-8 levels and amniotic fluid IL-6, IL-8 and TNF-alpha levels were higher than those of controls, and the differences were significant between the two groups (p < 0.05). Although the levels of TNF-alpha in maternal serum were higher than that of controls, the difference was not significant. There were significant relationships between the levels of IL-6, IL-8 and TNF-alpha and the duration of PROM. The longer the duration of PROM, the higher the levels of maternal serum and amniotic fluid IL-6, IL-8 and TNF-alpha were. There were 12 cases of clinical chorioamnionitis, and the levels of IL-6, IL-8 and TNF-alpha in the maternal and amniotic fluid were higher than that of those without chorioamnionitis (p < 0.05). CONCLUSION: Determining cytokines (IL-6, IL-8 and TNF-alpha) is a valuable clinical method for identifying chorioamnionitis in patients with PROM. SN - 0578-1337 UR - https://www.unboundmedicine.com/medline/citation/10820910/Changes_in_cytokine__IL_8_IL_6_and_TNF_alpha__levels_in_the_amniotic_fluid_and_maternal_serum_in_patients_with_premature_rupture_of_the_membranes_ DB - PRIME DP - Unbound Medicine ER -