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Sandwiched osmotic tablet core for nifedipine controlled delivery.
Biomed Mater Eng. 1999; 9(5-6):297-310.BM

Abstract

The sandwiched osmotic tablet core, which is composed of a middle push layer and two attached drug layers, has been prepared and systematically studied with the purpose of delivering water-insoluble nifedipine. The advantage of the sandwiched osmotic tablet system over the commercialized push-pull osmotic tablet system is its simplicity of preparation, as the surface identification was avoided. It was observed that polyethylene oxides (PEO) with molecular weight (MW) of 300,000 and 8,000,000 g/mole were suitable for the thickening agent of drug layer and the expandable hydrogel of push layer, respectively. The weight ratio of 190/190 for drug layer/push layer was also found to be suitable. It has been observed that PEO amount of the push layer and the KCl amount of the drug layer had profoundly positive influence on nifedipine release. A push layer/drug layer co-controlled osmotic delivery mechanism has been proposed and the optimal tablet formulation has been obtained. It was also found that PEO and nifedipine were miscible, which may support the application of PEO in nifedipine dosage forms. Meanwhile, the PEO/nifedipine binary phase diagram has been constructed. The sandwiched osmotic tablet system can deliver nifedipine in an approximate zero-order rate up to 24 hours. It may be potentially used for the delivery of water-insoluble drugs.

Authors+Show Affiliations

Liu L
Department of Polymer Science and Technology, Chonbuk National University, Dukjin Ku, Chonju, Korea.
Khang G
No affiliation info available
Rhee JM
No affiliation info available
Lee HB
No affiliation info available

MeSH

Calcium Channel BlockersCalorimetry, Differential ScanningChemistry, PharmaceuticalChromatography, High Pressure LiquidDelayed-Action PreparationsDrug Delivery SystemsExcipientsHumansHydrogel, Polyethylene Glycol DimethacrylateLinear ModelsMolecular WeightNifedipineOsmosisPolyethylene GlycolsPotassium ChlorideSolubilityTabletsTime FactorsVasodilator AgentsWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10822485

Citation

Liu, L, et al. "Sandwiched Osmotic Tablet Core for Nifedipine Controlled Delivery." Bio-medical Materials and Engineering, vol. 9, no. 5-6, 1999, pp. 297-310.
Liu L, Khang G, Rhee JM, et al. Sandwiched osmotic tablet core for nifedipine controlled delivery. Biomed Mater Eng. 1999;9(5-6):297-310.
Liu, L., Khang, G., Rhee, J. M., & Lee, H. B. (1999). Sandwiched osmotic tablet core for nifedipine controlled delivery. Bio-medical Materials and Engineering, 9(5-6), 297-310.
Liu L, et al. Sandwiched Osmotic Tablet Core for Nifedipine Controlled Delivery. Biomed Mater Eng. 1999;9(5-6):297-310. PubMed PMID: 10822485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sandwiched osmotic tablet core for nifedipine controlled delivery. AU - Liu,L, AU - Khang,G, AU - Rhee,J M, AU - Lee,H B, PY - 2000/5/24/pubmed PY - 2000/6/17/medline PY - 2000/5/24/entrez SP - 297 EP - 310 JF - Bio-medical materials and engineering JO - Biomed Mater Eng VL - 9 IS - 5-6 N2 - The sandwiched osmotic tablet core, which is composed of a middle push layer and two attached drug layers, has been prepared and systematically studied with the purpose of delivering water-insoluble nifedipine. The advantage of the sandwiched osmotic tablet system over the commercialized push-pull osmotic tablet system is its simplicity of preparation, as the surface identification was avoided. It was observed that polyethylene oxides (PEO) with molecular weight (MW) of 300,000 and 8,000,000 g/mole were suitable for the thickening agent of drug layer and the expandable hydrogel of push layer, respectively. The weight ratio of 190/190 for drug layer/push layer was also found to be suitable. It has been observed that PEO amount of the push layer and the KCl amount of the drug layer had profoundly positive influence on nifedipine release. A push layer/drug layer co-controlled osmotic delivery mechanism has been proposed and the optimal tablet formulation has been obtained. It was also found that PEO and nifedipine were miscible, which may support the application of PEO in nifedipine dosage forms. Meanwhile, the PEO/nifedipine binary phase diagram has been constructed. The sandwiched osmotic tablet system can deliver nifedipine in an approximate zero-order rate up to 24 hours. It may be potentially used for the delivery of water-insoluble drugs. SN - 0959-2989 UR - https://www.unboundmedicine.com/medline/citation/10822485/Sandwiched_osmotic_tablet_core_for_nifedipine_controlled_delivery_ DB - PRIME DP - Unbound Medicine ER -