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[Treatment of leukemia relapsed after allogenic bone marrow transplantation with donor lymphocyte infusion: report of 11 cases].
Sangre (Barc). 1999 Dec; 44(6):456-63.S

Abstract

PURPOSE

Donor leukocyte infusions (DLI) are useful for treating leukaemic relapse after allogeneic bone marrow transplantation (BMT). We reviewed our experience with eleven patients who received DLI between 1995 and 1997.

PATIENTS AND METHODS

The diagnoses prior to DLI were: chronic myeloid leukaemia (CML) in chronic phase (CP) (two patients) or accelerated phase (two patients), acute myeloid leukaemia (AML) (two patients), acute lymphoid leukaemia (ALL) (two patients), and refractory anaemia with excess blasts under transformation (tRAEB) (three patients). The patients received a median of 1.72 x 10(8) CD3+ cells/Kg (range: 0.58 x 10(8) CD3+ cells/Kg). Four patients were infused cryopreserved cells. Six patients received interferon alpha (IFN alpha) concomitantly.

RESULTS

Seven patients (four CML, one AML, one ALL, one tRAEB) obtained complete remission (CR). Graft-versus-host disease (GVHD) was observed in all patients with CR and one without response. Marrow hypoplasia or severe bicytopenia occurred in four patients. Of all patients achieving CR, two died after relapsing within 3 months of DLI, while three others died of GVHD. Four patients had no response to DLI or were not evauable. Only two patients--both with CML--are alive 1096 and 374 days after DLI, the former in clinical, cytogenetic and molecular CR, and the latter in second CP after 2 months in CR.

CONCLUSIONS

DLI results in CR in most patients with relapsing leukaemia or myelodysplasia after BMT, especially in CML patients. The anti-leukaemia effect is highly correlated with GVHD. This complication and marrow hypoplasia remain major causes of morbidity and mortality of this procedure.

Authors+Show Affiliations

Servicio de Hematología, Hospital Universitario de la Princesa, Madrid.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

spa

PubMed ID

10822760

Citation

Sanz Rodríguez, C, et al. "[Treatment of Leukemia Relapsed After Allogenic Bone Marrow Transplantation With Donor Lymphocyte Infusion: Report of 11 Cases]." Sangre, vol. 44, no. 6, 1999, pp. 456-63.
Sanz Rodríguez C, Steegmann JL, Granda A, et al. [Treatment of leukemia relapsed after allogenic bone marrow transplantation with donor lymphocyte infusion: report of 11 cases]. Sangre (Barc). 1999;44(6):456-63.
Sanz Rodríguez, C., Steegmann, J. L., Granda, A., de la Cámara, R., Figuera, A., Arranz, R., Gómez-García de Soria, V., Alegre, A., & Fernández-Rañada, J. M. (1999). [Treatment of leukemia relapsed after allogenic bone marrow transplantation with donor lymphocyte infusion: report of 11 cases]. Sangre, 44(6), 456-63.
Sanz Rodríguez C, et al. [Treatment of Leukemia Relapsed After Allogenic Bone Marrow Transplantation With Donor Lymphocyte Infusion: Report of 11 Cases]. Sangre (Barc). 1999;44(6):456-63. PubMed PMID: 10822760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Treatment of leukemia relapsed after allogenic bone marrow transplantation with donor lymphocyte infusion: report of 11 cases]. AU - Sanz Rodríguez,C, AU - Steegmann,J L, AU - Granda,A, AU - de la Cámara,R, AU - Figuera,A, AU - Arranz,R, AU - Gómez-García de Soria,V, AU - Alegre,A, AU - Fernández-Rañada,J M, PY - 2000/5/24/pubmed PY - 2000/6/17/medline PY - 2000/5/24/entrez SP - 456 EP - 63 JF - Sangre JO - Sangre (Barc) VL - 44 IS - 6 N2 - PURPOSE: Donor leukocyte infusions (DLI) are useful for treating leukaemic relapse after allogeneic bone marrow transplantation (BMT). We reviewed our experience with eleven patients who received DLI between 1995 and 1997. PATIENTS AND METHODS: The diagnoses prior to DLI were: chronic myeloid leukaemia (CML) in chronic phase (CP) (two patients) or accelerated phase (two patients), acute myeloid leukaemia (AML) (two patients), acute lymphoid leukaemia (ALL) (two patients), and refractory anaemia with excess blasts under transformation (tRAEB) (three patients). The patients received a median of 1.72 x 10(8) CD3+ cells/Kg (range: 0.58 x 10(8) CD3+ cells/Kg). Four patients were infused cryopreserved cells. Six patients received interferon alpha (IFN alpha) concomitantly. RESULTS: Seven patients (four CML, one AML, one ALL, one tRAEB) obtained complete remission (CR). Graft-versus-host disease (GVHD) was observed in all patients with CR and one without response. Marrow hypoplasia or severe bicytopenia occurred in four patients. Of all patients achieving CR, two died after relapsing within 3 months of DLI, while three others died of GVHD. Four patients had no response to DLI or were not evauable. Only two patients--both with CML--are alive 1096 and 374 days after DLI, the former in clinical, cytogenetic and molecular CR, and the latter in second CP after 2 months in CR. CONCLUSIONS: DLI results in CR in most patients with relapsing leukaemia or myelodysplasia after BMT, especially in CML patients. The anti-leukaemia effect is highly correlated with GVHD. This complication and marrow hypoplasia remain major causes of morbidity and mortality of this procedure. SN - 0036-4355 UR - https://www.unboundmedicine.com/medline/citation/10822760/[Treatment_of_leukemia_relapsed_after_allogenic_bone_marrow_transplantation_with_donor_lymphocyte_infusion:_report_of_11_cases]_ L2 - http://www.diseaseinfosearch.org/result/7171 DB - PRIME DP - Unbound Medicine ER -