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Increased cell-free viral DNA in fatal cases of chronic active Epstein-Barr virus infection.
Clin Infect Dis. 1999 Apr; 28(4):906-9.CI

Abstract

We have studied the nature of Epstein-Barr virus (EBV) infection in 33 patients with chronic active EBV infection. The study population included 14 patients with fatal chronic EBV infection and 19 patients with nonfatal chronic EBV infection, as well as 18 patients with acute EBV-induced infectious mononucleosis and 10 healthy controls. EBV DNA was measured in serum or plasma samples from the patients by semiquantitative polymerase chain reaction-based assay. EBV DNA was detected in serum or plasma samples from 62% (9/14) of patients with fatal chronic active EBV infection. In contrast, only 11% (2/19) of patients with nonfatal chronic active EBV infection and 11% (2/18) of patients with infectious mononucleosis displayed EBV DNA. None of the healthy controls tested positive. Cell-free circulating EBV DNA may represent an important feature of chronic active EBV infection and may provide a useful tool to monitor the severity of this illness.

Authors+Show Affiliations

Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan. kanegane@ms.toyama-mpu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10825059

Citation

Kanegane, H, et al. "Increased Cell-free Viral DNA in Fatal Cases of Chronic Active Epstein-Barr Virus Infection." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 28, no. 4, 1999, pp. 906-9.
Kanegane H, Wakiguchi H, Kanegane C, et al. Increased cell-free viral DNA in fatal cases of chronic active Epstein-Barr virus infection. Clin Infect Dis. 1999;28(4):906-9.
Kanegane, H., Wakiguchi, H., Kanegane, C., Kurashige, T., Miyawaki, T., & Tosato, G. (1999). Increased cell-free viral DNA in fatal cases of chronic active Epstein-Barr virus infection. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 28(4), 906-9.
Kanegane H, et al. Increased Cell-free Viral DNA in Fatal Cases of Chronic Active Epstein-Barr Virus Infection. Clin Infect Dis. 1999;28(4):906-9. PubMed PMID: 10825059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased cell-free viral DNA in fatal cases of chronic active Epstein-Barr virus infection. AU - Kanegane,H, AU - Wakiguchi,H, AU - Kanegane,C, AU - Kurashige,T, AU - Miyawaki,T, AU - Tosato,G, PY - 2000/5/29/pubmed PY - 2000/7/6/medline PY - 2000/5/29/entrez SP - 906 EP - 9 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 28 IS - 4 N2 - We have studied the nature of Epstein-Barr virus (EBV) infection in 33 patients with chronic active EBV infection. The study population included 14 patients with fatal chronic EBV infection and 19 patients with nonfatal chronic EBV infection, as well as 18 patients with acute EBV-induced infectious mononucleosis and 10 healthy controls. EBV DNA was measured in serum or plasma samples from the patients by semiquantitative polymerase chain reaction-based assay. EBV DNA was detected in serum or plasma samples from 62% (9/14) of patients with fatal chronic active EBV infection. In contrast, only 11% (2/19) of patients with nonfatal chronic active EBV infection and 11% (2/18) of patients with infectious mononucleosis displayed EBV DNA. None of the healthy controls tested positive. Cell-free circulating EBV DNA may represent an important feature of chronic active EBV infection and may provide a useful tool to monitor the severity of this illness. SN - 1058-4838 UR - https://www.unboundmedicine.com/medline/citation/10825059/Increased_cell_free_viral_DNA_in_fatal_cases_of_chronic_active_Epstein_Barr_virus_infection_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/515224 DB - PRIME DP - Unbound Medicine ER -