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Treatment with 2% clindamycin vaginal cream prior to first trimester surgical abortion to reduce signs of postoperative infection: a prospective, double-blinded, placebo-controlled, multicenter study.
Acta Obstet Gynecol Scand. 2000 May; 79(5):390-6.AO

Abstract

BACKGROUND

Bacterial vaginosis (BV) and intermediate flora is known risk-factor for postoperative infection after surgical termination of pregnancy. Vaginal application of 2% clindamycin cream is an efficacious treatment for BV, but it is not known whether preoperative administration of clindamycin cream might reduce the signs of post-abortion infection after surgical termination of pregnancy.

AIM

To evaluate whether preoperative treatment with clindamycin cream might reduce the signs of post-abortion infection after legal abortion.

DESIGN

Prospective, double-blinded, placebo-controlled, multicenter study.

MATERIAL AND METHODS

Consecutive women attending for surgical termination prior to 11+4 gestational weeks were approached. We randomized participants to preoperative vaginal treatment with 2% clindamycin cream or placebo cream in a double-blinded fashion. At all visits vaginal smears were air dried on microscopy slides to be stored. The rate of postoperative pelvic infection according to our definition was the main outcome variable, the cure rates of BV and of intermediate flora were secondary outcome variables.

RESULTS

Of 1655 enrolled women, 1102 were evaluable for analyses. Fifty-eight women developed signs of post-abortion infection. Preoperative treatment with clindamycin cream significantly (RR: 4.2, 95% C.I. 1.2-15.9) reduced the risk of post-abortion infection among women with abnormal vaginal flora (BV and intermediate flora). Treatment with clindamycin cream in women with normal lactobacilli flora did not demonstrate any difference compared to the non-treatment group.

CONCLUSION

Preoperative treatment for at least three days with clindamycin cream significantly reduced the risk for developing signs of post-abortion infection only among women with preoperative abnormal vaginal flora (BV and intermediate flora).

Authors+Show Affiliations

Department of Obstetrics and Gynaecology at the Central Hospital of Skövde, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10830767

Citation

Larsson, P G., et al. "Treatment With 2% Clindamycin Vaginal Cream Prior to First Trimester Surgical Abortion to Reduce Signs of Postoperative Infection: a Prospective, Double-blinded, Placebo-controlled, Multicenter Study." Acta Obstetricia Et Gynecologica Scandinavica, vol. 79, no. 5, 2000, pp. 390-6.
Larsson PG, Platz-Christensen JJ, Dalaker K, et al. Treatment with 2% clindamycin vaginal cream prior to first trimester surgical abortion to reduce signs of postoperative infection: a prospective, double-blinded, placebo-controlled, multicenter study. Acta Obstet Gynecol Scand. 2000;79(5):390-6.
Larsson, P. G., Platz-Christensen, J. J., Dalaker, K., Eriksson, K., Fåhraeus, L., Irminger, K., Jerve, F., Stray-Pedersen, B., & Wölner-Hanssen, P. (2000). Treatment with 2% clindamycin vaginal cream prior to first trimester surgical abortion to reduce signs of postoperative infection: a prospective, double-blinded, placebo-controlled, multicenter study. Acta Obstetricia Et Gynecologica Scandinavica, 79(5), 390-6.
Larsson PG, et al. Treatment With 2% Clindamycin Vaginal Cream Prior to First Trimester Surgical Abortion to Reduce Signs of Postoperative Infection: a Prospective, Double-blinded, Placebo-controlled, Multicenter Study. Acta Obstet Gynecol Scand. 2000;79(5):390-6. PubMed PMID: 10830767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment with 2% clindamycin vaginal cream prior to first trimester surgical abortion to reduce signs of postoperative infection: a prospective, double-blinded, placebo-controlled, multicenter study. AU - Larsson,P G, AU - Platz-Christensen,J J, AU - Dalaker,K, AU - Eriksson,K, AU - Fåhraeus,L, AU - Irminger,K, AU - Jerve,F, AU - Stray-Pedersen,B, AU - Wölner-Hanssen,P, PY - 2000/6/1/pubmed PY - 2000/6/17/medline PY - 2000/6/1/entrez SP - 390 EP - 6 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 79 IS - 5 N2 - BACKGROUND: Bacterial vaginosis (BV) and intermediate flora is known risk-factor for postoperative infection after surgical termination of pregnancy. Vaginal application of 2% clindamycin cream is an efficacious treatment for BV, but it is not known whether preoperative administration of clindamycin cream might reduce the signs of post-abortion infection after surgical termination of pregnancy. AIM: To evaluate whether preoperative treatment with clindamycin cream might reduce the signs of post-abortion infection after legal abortion. DESIGN: Prospective, double-blinded, placebo-controlled, multicenter study. MATERIAL AND METHODS: Consecutive women attending for surgical termination prior to 11+4 gestational weeks were approached. We randomized participants to preoperative vaginal treatment with 2% clindamycin cream or placebo cream in a double-blinded fashion. At all visits vaginal smears were air dried on microscopy slides to be stored. The rate of postoperative pelvic infection according to our definition was the main outcome variable, the cure rates of BV and of intermediate flora were secondary outcome variables. RESULTS: Of 1655 enrolled women, 1102 were evaluable for analyses. Fifty-eight women developed signs of post-abortion infection. Preoperative treatment with clindamycin cream significantly (RR: 4.2, 95% C.I. 1.2-15.9) reduced the risk of post-abortion infection among women with abnormal vaginal flora (BV and intermediate flora). Treatment with clindamycin cream in women with normal lactobacilli flora did not demonstrate any difference compared to the non-treatment group. CONCLUSION: Preoperative treatment for at least three days with clindamycin cream significantly reduced the risk for developing signs of post-abortion infection only among women with preoperative abnormal vaginal flora (BV and intermediate flora). SN - 0001-6349 UR - https://www.unboundmedicine.com/medline/citation/10830767/Treatment_with_2_clindamycin_vaginal_cream_prior_to_first_trimester_surgical_abortion_to_reduce_signs_of_postoperative_infection:_a_prospective_double_blinded_placebo_controlled_multicenter_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10830767.ui DB - PRIME DP - Unbound Medicine ER -