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[The nootropic and anxiolytic properties of different doses of piracetam].
Eksp Klin Farmakol. 2000 Mar-Apr; 63(2):9-11.EK

Abstract

The effect of piracetam at various doses on the behavioral and electrophysiological characteristics was studied, including the development of passive and active avoidance conditional reflexes in rats, their behavior in conflict situations, and the transcallosal evoked response (TER) in rabbit brain. In the dose range from 50 to 300 mg/kg, piracetam improved the avoidance performance of both types and produced a dose-dependent increase in the TER amplitude, but did not affect the behavior of rats in conflict situations. As the drug dose was increased to 400-1000 mg/kg, the positive learning influence disappeared (sometimes the effect was even negative) and the TER increase changed to decrease. In contrast, the conflict situation tests revealed pronounced anxiolytic activity of piracetam at elevated doses. Thus, the nootropic and anxiolytic effects of piracetam (and, probably, of the other tranquilizers as well) do not coexist and are significantly shifted relative to one another on the dose scale, being probably realized via different mechanisms.

Authors+Show Affiliations

Voronina TA
Laboratory of Psychopharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Molodavkin GM
No affiliation info available
Borlikova GG
No affiliation info available
Ostrovskaia RU
No affiliation info available
Tushmalova NA
No affiliation info available
Naznamov GG
No affiliation info available

MeSH

AnimalsAnti-Anxiety AgentsAvoidance LearningConditioning, ClassicalConflict, PsychologicalCorpus CallosumDose-Response Relationship, DrugEvoked PotentialsMaleNootropic AgentsPiracetamRabbitsRatsReaction TimeStatistics, NonparametricTime Factors

Pub Type(s)

Journal Article

Language

rus

PubMed ID

10834086

Citation

Voronina, T A., et al. "[The Nootropic and Anxiolytic Properties of Different Doses of Piracetam]." Eksperimental'naia I Klinicheskaia Farmakologiia, vol. 63, no. 2, 2000, pp. 9-11.
Voronina TA, Molodavkin GM, Borlikova GG, et al. [The nootropic and anxiolytic properties of different doses of piracetam]. Eksp Klin Farmakol. 2000;63(2):9-11.
Voronina, T. A., Molodavkin, G. M., Borlikova, G. G., Ostrovskaia, R. U., Tushmalova, N. A., & Naznamov, G. G. (2000). [The nootropic and anxiolytic properties of different doses of piracetam]. Eksperimental'naia I Klinicheskaia Farmakologiia, 63(2), 9-11.
Voronina TA, et al. [The Nootropic and Anxiolytic Properties of Different Doses of Piracetam]. Eksp Klin Farmakol. 2000 Mar-Apr;63(2):9-11. PubMed PMID: 10834086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The nootropic and anxiolytic properties of different doses of piracetam]. AU - Voronina,T A, AU - Molodavkin,G M, AU - Borlikova,G G, AU - Ostrovskaia,R U, AU - Tushmalova,N A, AU - Naznamov,G G, PY - 2000/6/2/pubmed PY - 2000/6/2/medline PY - 2000/6/2/entrez SP - 9 EP - 11 JF - Eksperimental'naia i klinicheskaia farmakologiia JO - Eksp Klin Farmakol VL - 63 IS - 2 N2 - The effect of piracetam at various doses on the behavioral and electrophysiological characteristics was studied, including the development of passive and active avoidance conditional reflexes in rats, their behavior in conflict situations, and the transcallosal evoked response (TER) in rabbit brain. In the dose range from 50 to 300 mg/kg, piracetam improved the avoidance performance of both types and produced a dose-dependent increase in the TER amplitude, but did not affect the behavior of rats in conflict situations. As the drug dose was increased to 400-1000 mg/kg, the positive learning influence disappeared (sometimes the effect was even negative) and the TER increase changed to decrease. In contrast, the conflict situation tests revealed pronounced anxiolytic activity of piracetam at elevated doses. Thus, the nootropic and anxiolytic effects of piracetam (and, probably, of the other tranquilizers as well) do not coexist and are significantly shifted relative to one another on the dose scale, being probably realized via different mechanisms. SN - 0869-2092 UR - https://www.unboundmedicine.com/medline/citation/10834086/[The_nootropic_and_anxiolytic_properties_of_different_doses_of_piracetam]_ DB - PRIME DP - Unbound Medicine ER -