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Mycobacterium bovis as a significant cause of tuberculosis in children residing along the United States-Mexico border in the Baja California region.
Pediatrics. 2000 Jun; 105(6):E79.Ped

Abstract

OBJECTIVE

To determine the role of Mycobacterium bovis in active pediatric tuberculosis (TB) in a United States-Mexico border region.

METHOD

We reviewed all new cases of pediatric (<15 years old) TB presenting to San Diego hospitals and clinics from 1980 to 1997. Patients were categorized by age, ethnicity, country of origin, culture results, and disease manifestations. Case definitions were similar to those used by the Centers for Disease Control and Prevention. M bovis was distinguished from Mycobacterium tuberculosis by standard biochemical tests.

RESULTS

The median age of the 563 identified patients was 4.1 years old. The yearly incidence began rising in 1989 and peaked in the mid-1990s. Hispanics constituted 78.9% of the patients, but they were less likely to be foreign-born (21.6%) than were black children and Asian/Pacific Islanders. Overall, M bovis caused 10.8% of all TB during this period. Of the 180 patients with positive culture results, however, M bovis accounted for 33.9% and M tuberculosis 66. 1%. This high percentage of M bovis infections was largely attributable to its contribution to extrapulmonary TB (55.2% of all culture-positive specimens). M bovis patients were also even more likely to be Hispanic (90.2%), to present with extrapulmonary disease (95.1%), and to be older than 12 months (96.8%).

CONCLUSION

These data demonstrate the dramatic impact of this underappreciated cause of zoonotic TB on US children at the Mexican border and underscore the need for cross-collaboration to enforce existing Mexican pasteurization laws.

Authors+Show Affiliations

Department of Pediatrics, University of California, San Diego, San Diego, California 92103, USA. wdankner@ucsd.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10835092

Citation

Dankner, W M., and C E. Davis. "Mycobacterium Bovis as a Significant Cause of Tuberculosis in Children Residing Along the United States-Mexico Border in the Baja California Region." Pediatrics, vol. 105, no. 6, 2000, pp. E79.
Dankner WM, Davis CE. Mycobacterium bovis as a significant cause of tuberculosis in children residing along the United States-Mexico border in the Baja California region. Pediatrics. 2000;105(6):E79.
Dankner, W. M., & Davis, C. E. (2000). Mycobacterium bovis as a significant cause of tuberculosis in children residing along the United States-Mexico border in the Baja California region. Pediatrics, 105(6), E79.
Dankner WM, Davis CE. Mycobacterium Bovis as a Significant Cause of Tuberculosis in Children Residing Along the United States-Mexico Border in the Baja California Region. Pediatrics. 2000;105(6):E79. PubMed PMID: 10835092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mycobacterium bovis as a significant cause of tuberculosis in children residing along the United States-Mexico border in the Baja California region. AU - Dankner,W M, AU - Davis,C E, PY - 2000/6/2/pubmed PY - 2000/6/17/medline PY - 2000/6/2/entrez SP - E79 EP - E79 JF - Pediatrics JO - Pediatrics VL - 105 IS - 6 N2 - OBJECTIVE: To determine the role of Mycobacterium bovis in active pediatric tuberculosis (TB) in a United States-Mexico border region. METHOD: We reviewed all new cases of pediatric (<15 years old) TB presenting to San Diego hospitals and clinics from 1980 to 1997. Patients were categorized by age, ethnicity, country of origin, culture results, and disease manifestations. Case definitions were similar to those used by the Centers for Disease Control and Prevention. M bovis was distinguished from Mycobacterium tuberculosis by standard biochemical tests. RESULTS: The median age of the 563 identified patients was 4.1 years old. The yearly incidence began rising in 1989 and peaked in the mid-1990s. Hispanics constituted 78.9% of the patients, but they were less likely to be foreign-born (21.6%) than were black children and Asian/Pacific Islanders. Overall, M bovis caused 10.8% of all TB during this period. Of the 180 patients with positive culture results, however, M bovis accounted for 33.9% and M tuberculosis 66. 1%. This high percentage of M bovis infections was largely attributable to its contribution to extrapulmonary TB (55.2% of all culture-positive specimens). M bovis patients were also even more likely to be Hispanic (90.2%), to present with extrapulmonary disease (95.1%), and to be older than 12 months (96.8%). CONCLUSION: These data demonstrate the dramatic impact of this underappreciated cause of zoonotic TB on US children at the Mexican border and underscore the need for cross-collaboration to enforce existing Mexican pasteurization laws. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/10835092/Mycobacterium_bovis_as_a_significant_cause_of_tuberculosis_in_children_residing_along_the_United_States_Mexico_border_in_the_Baja_California_region_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&amp;pmid=10835092 DB - PRIME DP - Unbound Medicine ER -