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[Respiratory function impairment in patients with Parkinson's disease--a consideration on the possible pathogenetic relation to autonomic dysfunction].
Rinsho Shinkeigaku. 2000 Feb; 40(2):125-30.RS

Abstract

To investigate the characteristics and clinical significance of respiratory function in patients with Parkinson's disease (PD), we studied 38 patients (male, 19; female, 19: mean age, 65.5 years: mean duration of disease, 6.7 years) who had no history of respiratory disease and smoking. Fifty three non-respiratory disease subjects (male, 26; female, 27: mean age, 67.6 years) were served as age-matched control. We measured spirometry and maximal expiratory flow-volume curve in all patients, and analyzed the relations between respiratory function variables and clinical profiles. The clinical disability of PD was indicated by Hoehn-Yahr (H-Y) scale. The number of PD patients was 15 in H-Y 2, 18 in H-Y 3 and 5 in H-Y 4, respectively. The values of % VC, %FEV 1, FEV 1/FVC, %PEFR, % V50 in H-Y 4 group were significantly smaller than those in H-Y 2 and 3 groups. Small airway dysfunction (SAD) was represented by abnormality of % V25, % V50/V25. The prevalence of impairment in % V25 and % V50/V25 was detected in 13 patients (34.2%) and 15 patients (39.5%), respectively, this was significantly higher than age-matched controls. However, the mean value and prevalence of impairment in % V25, % V50/V25 were not affected by H-Y scale and duration of disease or ideal body weight (%predicted value). Twenty seven patients showed normal ventilatory function based on % VC over 80% and FEV 1/FVC over 70%. The prevalence of impairment in % V25, % V50/V25 was detected in 8 patients (29.6%), 9 patients (33.3%), respectively, among 27 patients with normal ventilatory function. These results suggest that ventilatory dysfunction is concerned with clinical disability but SAD which is independent of clinical disability seen prevalently in patients with PD. It is widely accepted that patients with PD frequently have cardiac or bowel dysfunction based on the visceral autonomic dysfunction. We hypothesize that SAD may also be caused by possible autonomic dysfunction in patients with PD.

Authors+Show Affiliations

Department of Medicine, Showa University, Fujigaoka Hospital.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

10835931

Citation

Yamada, H, et al. "[Respiratory Function Impairment in Patients With Parkinson's Disease--a Consideration On the Possible Pathogenetic Relation to Autonomic Dysfunction]." Rinsho Shinkeigaku = Clinical Neurology, vol. 40, no. 2, 2000, pp. 125-30.
Yamada H, Murahashi M, Takahashi H, et al. [Respiratory function impairment in patients with Parkinson's disease--a consideration on the possible pathogenetic relation to autonomic dysfunction]. Rinsho Shinkeigaku. 2000;40(2):125-30.
Yamada, H., Murahashi, M., Takahashi, H., Kai, K., Shibuya, S., Jimi, T., Wakayama, Y., & Yamada, M. (2000). [Respiratory function impairment in patients with Parkinson's disease--a consideration on the possible pathogenetic relation to autonomic dysfunction]. Rinsho Shinkeigaku = Clinical Neurology, 40(2), 125-30.
Yamada H, et al. [Respiratory Function Impairment in Patients With Parkinson's Disease--a Consideration On the Possible Pathogenetic Relation to Autonomic Dysfunction]. Rinsho Shinkeigaku. 2000;40(2):125-30. PubMed PMID: 10835931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Respiratory function impairment in patients with Parkinson's disease--a consideration on the possible pathogenetic relation to autonomic dysfunction]. AU - Yamada,H, AU - Murahashi,M, AU - Takahashi,H, AU - Kai,K, AU - Shibuya,S, AU - Jimi,T, AU - Wakayama,Y, AU - Yamada,M, PY - 2000/6/3/pubmed PY - 2000/8/12/medline PY - 2000/6/3/entrez SP - 125 EP - 30 JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku VL - 40 IS - 2 N2 - To investigate the characteristics and clinical significance of respiratory function in patients with Parkinson's disease (PD), we studied 38 patients (male, 19; female, 19: mean age, 65.5 years: mean duration of disease, 6.7 years) who had no history of respiratory disease and smoking. Fifty three non-respiratory disease subjects (male, 26; female, 27: mean age, 67.6 years) were served as age-matched control. We measured spirometry and maximal expiratory flow-volume curve in all patients, and analyzed the relations between respiratory function variables and clinical profiles. The clinical disability of PD was indicated by Hoehn-Yahr (H-Y) scale. The number of PD patients was 15 in H-Y 2, 18 in H-Y 3 and 5 in H-Y 4, respectively. The values of % VC, %FEV 1, FEV 1/FVC, %PEFR, % V50 in H-Y 4 group were significantly smaller than those in H-Y 2 and 3 groups. Small airway dysfunction (SAD) was represented by abnormality of % V25, % V50/V25. The prevalence of impairment in % V25 and % V50/V25 was detected in 13 patients (34.2%) and 15 patients (39.5%), respectively, this was significantly higher than age-matched controls. However, the mean value and prevalence of impairment in % V25, % V50/V25 were not affected by H-Y scale and duration of disease or ideal body weight (%predicted value). Twenty seven patients showed normal ventilatory function based on % VC over 80% and FEV 1/FVC over 70%. The prevalence of impairment in % V25, % V50/V25 was detected in 8 patients (29.6%), 9 patients (33.3%), respectively, among 27 patients with normal ventilatory function. These results suggest that ventilatory dysfunction is concerned with clinical disability but SAD which is independent of clinical disability seen prevalently in patients with PD. It is widely accepted that patients with PD frequently have cardiac or bowel dysfunction based on the visceral autonomic dysfunction. We hypothesize that SAD may also be caused by possible autonomic dysfunction in patients with PD. SN - 0009-918X UR - https://www.unboundmedicine.com/medline/citation/10835931/[Respiratory_function_impairment_in_patients_with_Parkinson's_disease__a_consideration_on_the_possible_pathogenetic_relation_to_autonomic_dysfunction]_ L2 - https://ClinicalTrials.gov/search/term=10835931 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -