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Serum anticholinergic activity levels and delirium in the elderly.
Semin Clin Neuropsychiatry. 2000 Apr; 5(2):149-53.SC

Abstract

This article will briefly review the clinical studies focusing on measurement of serum levels of anticholinergic activity in delirious states. Three experimental approaches have been taken. First, to identify medications currently prescribed that have subtle anticholinergic effects. The current "list" includes 48 commonly prescribed medications. Second, to associate serum anticholinergic activity with delirium in various clinical states including postcardiotomy delirium, postelectroconvulsive delirium, delirious elderly medical inpatients, and nursing home patients. Third, to intervene in patients with elevated anticholinergic activity by reducing known anticholinergics and correlating this reduction with clinical measures of cognition and delirium. Our most recent data investigate the impact of anticholinergics on demented patients. Prevalence of delirium was significantly higher in patients receiving larger numbers of anticholinergics.

Authors+Show Affiliations

Department of Psychiatry and Behavioral Sciences, Geriatrics, Emory University School of Medicine, Atlanta, GA, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10837103

Citation

Tune, L E.. "Serum Anticholinergic Activity Levels and Delirium in the Elderly." Seminars in Clinical Neuropsychiatry, vol. 5, no. 2, 2000, pp. 149-53.
Tune LE. Serum anticholinergic activity levels and delirium in the elderly. Semin Clin Neuropsychiatry. 2000;5(2):149-53.
Tune, L. E. (2000). Serum anticholinergic activity levels and delirium in the elderly. Seminars in Clinical Neuropsychiatry, 5(2), 149-53.
Tune LE. Serum Anticholinergic Activity Levels and Delirium in the Elderly. Semin Clin Neuropsychiatry. 2000;5(2):149-53. PubMed PMID: 10837103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum anticholinergic activity levels and delirium in the elderly. A1 - Tune,L E, PY - 2000/6/3/pubmed PY - 2000/7/8/medline PY - 2000/6/3/entrez SP - 149 EP - 53 JF - Seminars in clinical neuropsychiatry JO - Semin Clin Neuropsychiatry VL - 5 IS - 2 N2 - This article will briefly review the clinical studies focusing on measurement of serum levels of anticholinergic activity in delirious states. Three experimental approaches have been taken. First, to identify medications currently prescribed that have subtle anticholinergic effects. The current "list" includes 48 commonly prescribed medications. Second, to associate serum anticholinergic activity with delirium in various clinical states including postcardiotomy delirium, postelectroconvulsive delirium, delirious elderly medical inpatients, and nursing home patients. Third, to intervene in patients with elevated anticholinergic activity by reducing known anticholinergics and correlating this reduction with clinical measures of cognition and delirium. Our most recent data investigate the impact of anticholinergics on demented patients. Prevalence of delirium was significantly higher in patients receiving larger numbers of anticholinergics. SN - 1084-3612 UR - https://www.unboundmedicine.com/medline/citation/10837103/Serum_anticholinergic_activity_levels_and_delirium_in_the_elderly_ DB - PRIME DP - Unbound Medicine ER -
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