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Rhinoviruses infect the lower airways.
J Infect Dis. 2000 Jun; 181(6):1875-84.JI

Abstract

Rhinoviruses are the major cause of the common cold and a trigger of acute asthma exacerbations. Whether these exacerbations result from direct infection of the lower airway or from indirect mechanisms consequent on infection of the upper airway alone is currently unknown. Lower respiratory infection was investigated in vitro by exposing primary human bronchial epithelial cells to rhinoviruses and in vivo after experimental upper respiratory infection of human volunteers. Bronchial infection was confirmed by both approaches. Furthermore, rhinoviruses induced production of interleukin-6, -8, and -16 and RANTES and were cytotoxic to cultured respiratory epithelium. This evidence strongly supports a direct lower respiratory epithelial reaction as the initial event in the induction of rhinovirus-mediated asthma exacerbations. The frequency of infection and the nature of the inflammatory response observed are similar to those of the upper respiratory tract, suggesting that rhinovirus infections may be one of the most important causes of lower in addition to upper respiratory disease.

Authors+Show Affiliations

University Medicine, Southampton General Hospital, Southampton, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10837165

Citation

Papadopoulos, N G., et al. "Rhinoviruses Infect the Lower Airways." The Journal of Infectious Diseases, vol. 181, no. 6, 2000, pp. 1875-84.
Papadopoulos NG, Bates PJ, Bardin PG, et al. Rhinoviruses infect the lower airways. J Infect Dis. 2000;181(6):1875-84.
Papadopoulos, N. G., Bates, P. J., Bardin, P. G., Papi, A., Leir, S. H., Fraenkel, D. J., Meyer, J., Lackie, P. M., Sanderson, G., Holgate, S. T., & Johnston, S. L. (2000). Rhinoviruses infect the lower airways. The Journal of Infectious Diseases, 181(6), 1875-84.
Papadopoulos NG, et al. Rhinoviruses Infect the Lower Airways. J Infect Dis. 2000;181(6):1875-84. PubMed PMID: 10837165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rhinoviruses infect the lower airways. AU - Papadopoulos,N G, AU - Bates,P J, AU - Bardin,P G, AU - Papi,A, AU - Leir,S H, AU - Fraenkel,D J, AU - Meyer,J, AU - Lackie,P M, AU - Sanderson,G, AU - Holgate,S T, AU - Johnston,S L, Y1 - 2000/06/05/ PY - 1999/11/17/received PY - 2000/02/08/revised PY - 2000/6/6/pubmed PY - 2000/8/1/medline PY - 2000/6/6/entrez SP - 1875 EP - 84 JF - The Journal of infectious diseases JO - J Infect Dis VL - 181 IS - 6 N2 - Rhinoviruses are the major cause of the common cold and a trigger of acute asthma exacerbations. Whether these exacerbations result from direct infection of the lower airway or from indirect mechanisms consequent on infection of the upper airway alone is currently unknown. Lower respiratory infection was investigated in vitro by exposing primary human bronchial epithelial cells to rhinoviruses and in vivo after experimental upper respiratory infection of human volunteers. Bronchial infection was confirmed by both approaches. Furthermore, rhinoviruses induced production of interleukin-6, -8, and -16 and RANTES and were cytotoxic to cultured respiratory epithelium. This evidence strongly supports a direct lower respiratory epithelial reaction as the initial event in the induction of rhinovirus-mediated asthma exacerbations. The frequency of infection and the nature of the inflammatory response observed are similar to those of the upper respiratory tract, suggesting that rhinovirus infections may be one of the most important causes of lower in addition to upper respiratory disease. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10837165/Rhinoviruses_infect_the_lower_airways_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315513 DB - PRIME DP - Unbound Medicine ER -