Tags

Type your tag names separated by a space and hit enter

Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density.
Am J Clin Nutr. 2000 Jun; 71(6):1555-62.AJ

Abstract

BACKGROUND

Lutein and zeaxanthin are the only carotenoids in the macular region of the retina (referred to as macular pigment [MP]). Foods that are rich in lutein and zeaxanthin can increase MP density. Response to dietary lutein and zeaxanthin in other tissues has not been studied.

OBJECTIVE

The objective of this study was to examine tissue responses to dietary lutein and zeaxanthin and relations among tissues in lutein and zeaxanthin concentrations.

DESIGN

Seven subjects consumed spinach and corn, which contain lutein and zeaxanthin, with their daily diets for 15 wk. At 0, 4, 8, and 15 wk and 2 mo after the study, serum, buccal mucosa cells, and adipose tissue were analyzed for carotenoids, and MP density was measured.

RESULTS

Serum and buccal cell concentrations of lutein increased significantly from baseline during dietary modification. Serum zeaxanthin concentrations were greater than at baseline only at 4 wk, whereas buccal cell and adipose tissue concentrations of zeaxanthin did not change. Adipose tissue lutein concentrations peaked at 8 wk. Changes in adipose tissue lutein concentration were inversely related to the changes in MP density, suggesting an interaction between adipose tissue and retina in lutein metabolism. To investigate the possibility of tissue interactions, we examined cross-sectional relations among serum, tissue, and dietary lutein concentrations, anthropometric measures, and MP density in healthy adults. Significant negative correlations were found between adipose tissue lutein concentrations and MP for women, but a significant positive relation was found for men.

CONCLUSION

Sex differences in lutein metabolism may be an important factor in tissue interactions and in determining MP density.

Authors+Show Affiliations

Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

10837298

Citation

Johnson, E J., et al. "Relation Among Serum and Tissue Concentrations of Lutein and Zeaxanthin and Macular Pigment Density." The American Journal of Clinical Nutrition, vol. 71, no. 6, 2000, pp. 1555-62.
Johnson EJ, Hammond BR, Yeum KJ, et al. Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. Am J Clin Nutr. 2000;71(6):1555-62.
Johnson, E. J., Hammond, B. R., Yeum, K. J., Qin, J., Wang, X. D., Castaneda, C., Snodderly, D. M., & Russell, R. M. (2000). Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. The American Journal of Clinical Nutrition, 71(6), 1555-62.
Johnson EJ, et al. Relation Among Serum and Tissue Concentrations of Lutein and Zeaxanthin and Macular Pigment Density. Am J Clin Nutr. 2000;71(6):1555-62. PubMed PMID: 10837298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. AU - Johnson,E J, AU - Hammond,B R, AU - Yeum,K J, AU - Qin,J, AU - Wang,X D, AU - Castaneda,C, AU - Snodderly,D M, AU - Russell,R M, PY - 2000/6/6/pubmed PY - 2000/7/25/medline PY - 2000/6/6/entrez SP - 1555 EP - 62 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 71 IS - 6 N2 - BACKGROUND: Lutein and zeaxanthin are the only carotenoids in the macular region of the retina (referred to as macular pigment [MP]). Foods that are rich in lutein and zeaxanthin can increase MP density. Response to dietary lutein and zeaxanthin in other tissues has not been studied. OBJECTIVE: The objective of this study was to examine tissue responses to dietary lutein and zeaxanthin and relations among tissues in lutein and zeaxanthin concentrations. DESIGN: Seven subjects consumed spinach and corn, which contain lutein and zeaxanthin, with their daily diets for 15 wk. At 0, 4, 8, and 15 wk and 2 mo after the study, serum, buccal mucosa cells, and adipose tissue were analyzed for carotenoids, and MP density was measured. RESULTS: Serum and buccal cell concentrations of lutein increased significantly from baseline during dietary modification. Serum zeaxanthin concentrations were greater than at baseline only at 4 wk, whereas buccal cell and adipose tissue concentrations of zeaxanthin did not change. Adipose tissue lutein concentrations peaked at 8 wk. Changes in adipose tissue lutein concentration were inversely related to the changes in MP density, suggesting an interaction between adipose tissue and retina in lutein metabolism. To investigate the possibility of tissue interactions, we examined cross-sectional relations among serum, tissue, and dietary lutein concentrations, anthropometric measures, and MP density in healthy adults. Significant negative correlations were found between adipose tissue lutein concentrations and MP for women, but a significant positive relation was found for men. CONCLUSION: Sex differences in lutein metabolism may be an important factor in tissue interactions and in determining MP density. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/10837298/Relation_among_serum_and_tissue_concentrations_of_lutein_and_zeaxanthin_and_macular_pigment_density_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/71.6.1555 DB - PRIME DP - Unbound Medicine ER -