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Enantiomer separation of drugs by capillary electromigration techniques.
J Chromatogr A. 2000 Apr 14; 875(1-2):3-25.JC

Abstract

The review summarizes the most recent developments in the field of enantioseparation of chiral drugs using capillary electromigration techniques. The basic principles of enantioseparations in CE are discussed. Recent developments in sample introduction, separation and detection in capillary electrophoresis and capillary electrochromatography are summarized. The applications are arbitrarily divided into the following three groups: (a) racemates and artificial mixtures of enantiomers, (b) drug forms and (c) chiral drugs and their metabolites in biological fluids. Among the various techniques involved the relatively new developments such as CEC in aqueous and nonaqueous buffers, on-line CE-MS coupling, etc. are emphasized.

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Authors+Show Affiliations

Blaschke G
Institute of Pharmaceutical Chemistry, University of Münster, Germany. blaschg@uni-muenster.de
Chankvetadze B
No affiliation info available

MeSH

Electrophoresis, CapillaryPharmaceutical PreparationsStereoisomerism

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10839137

Citation

Blaschke, G, and B Chankvetadze. "Enantiomer Separation of Drugs By Capillary Electromigration Techniques." Journal of Chromatography. A, vol. 875, no. 1-2, 2000, pp. 3-25.
Blaschke G, Chankvetadze B. Enantiomer separation of drugs by capillary electromigration techniques. J Chromatogr A. 2000;875(1-2):3-25.
Blaschke, G., & Chankvetadze, B. (2000). Enantiomer separation of drugs by capillary electromigration techniques. Journal of Chromatography. A, 875(1-2), 3-25.
Blaschke G, Chankvetadze B. Enantiomer Separation of Drugs By Capillary Electromigration Techniques. J Chromatogr A. 2000 Apr 14;875(1-2):3-25. PubMed PMID: 10839137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enantiomer separation of drugs by capillary electromigration techniques. AU - Blaschke,G, AU - Chankvetadze,B, PY - 2000/6/6/pubmed PY - 2000/9/9/medline PY - 2000/6/6/entrez SP - 3 EP - 25 JF - Journal of chromatography. A JO - J Chromatogr A VL - 875 IS - 1-2 N2 - The review summarizes the most recent developments in the field of enantioseparation of chiral drugs using capillary electromigration techniques. The basic principles of enantioseparations in CE are discussed. Recent developments in sample introduction, separation and detection in capillary electrophoresis and capillary electrochromatography are summarized. The applications are arbitrarily divided into the following three groups: (a) racemates and artificial mixtures of enantiomers, (b) drug forms and (c) chiral drugs and their metabolites in biological fluids. Among the various techniques involved the relatively new developments such as CEC in aqueous and nonaqueous buffers, on-line CE-MS coupling, etc. are emphasized. SN - 0021-9673 UR - https://www.unboundmedicine.com/medline/citation/10839137/Enantiomer_separation_of_drugs_by_capillary_electromigration_techniques_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(00)00134-5 DB - PRIME DP - Unbound Medicine ER -