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Intrasellar chordomas mimicking pituitary adenoma.
J Neurosurg. 2000 Jun; 92(6):976-82.JN

Abstract

OBJECT

Whereas chordomas involving the sellar region are uncommon, largely or entirely intrasellar examples are rare. The goal in this study was to present examples of these rare tumors as a guide to their proper diagnosis and treatment.

METHODS

The authors report three cases in which the chordomas filled the pituitary fossa and presented as nonfunctioning pituitary adenomas. All lesions exhibited the typical histological patterns and immunophenotype of chordoma. One tumor, studied ultrastructurally and subjected to DNA analysis, was shown to have a diploid histogram. The authors present a clinicopathological study of these three cases and review the literature on intrasellar chordomas.

CONCLUSIONS

Although these tumors are easily misdiagnosed and therefore may not receive optimal treatment, aggressive surgical resection can yield a favorable prognosis in lesions with a limited extent.

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Publisher Full Text

Authors+Show Affiliations

Thodou E
Department of Pathology, General Hospital of Athens, Greece.
Kontogeorgos G
No affiliation info available
Scheithauer BW
No affiliation info available
Lekka I
No affiliation info available
Tzanis S
No affiliation info available
Mariatos P
No affiliation info available
Laws ER
No affiliation info available

MeSH

AdenomaAgedAged, 80 and overChordomaDiagnosis, DifferentialDiploidyFemaleHumansImmunophenotypingMaleMicroscopy, ElectronMiddle AgedPituitary NeoplasmsSella TurcicaSkull Neoplasms

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

10839258

Citation

Thodou, E, et al. "Intrasellar Chordomas Mimicking Pituitary Adenoma." Journal of Neurosurgery, vol. 92, no. 6, 2000, pp. 976-82.
Thodou E, Kontogeorgos G, Scheithauer BW, et al. Intrasellar chordomas mimicking pituitary adenoma. J Neurosurg. 2000;92(6):976-82.
Thodou, E., Kontogeorgos, G., Scheithauer, B. W., Lekka, I., Tzanis, S., Mariatos, P., & Laws, E. R. (2000). Intrasellar chordomas mimicking pituitary adenoma. Journal of Neurosurgery, 92(6), 976-82.
Thodou E, et al. Intrasellar Chordomas Mimicking Pituitary Adenoma. J Neurosurg. 2000;92(6):976-82. PubMed PMID: 10839258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrasellar chordomas mimicking pituitary adenoma. AU - Thodou,E, AU - Kontogeorgos,G, AU - Scheithauer,B W, AU - Lekka,I, AU - Tzanis,S, AU - Mariatos,P, AU - Laws,E R,Jr PY - 2000/6/6/pubmed PY - 2000/6/17/medline PY - 2000/6/6/entrez SP - 976 EP - 82 JF - Journal of neurosurgery JO - J Neurosurg VL - 92 IS - 6 N2 - OBJECT: Whereas chordomas involving the sellar region are uncommon, largely or entirely intrasellar examples are rare. The goal in this study was to present examples of these rare tumors as a guide to their proper diagnosis and treatment. METHODS: The authors report three cases in which the chordomas filled the pituitary fossa and presented as nonfunctioning pituitary adenomas. All lesions exhibited the typical histological patterns and immunophenotype of chordoma. One tumor, studied ultrastructurally and subjected to DNA analysis, was shown to have a diploid histogram. The authors present a clinicopathological study of these three cases and review the literature on intrasellar chordomas. CONCLUSIONS: Although these tumors are easily misdiagnosed and therefore may not receive optimal treatment, aggressive surgical resection can yield a favorable prognosis in lesions with a limited extent. SN - 0022-3085 UR - https://www.unboundmedicine.com/medline/citation/10839258/Intrasellar_chordomas_mimicking_pituitary_adenoma_ L2 - https://thejns.org/doi/10.3171/jns.2000.92.6.0976 DB - PRIME DP - Unbound Medicine ER -